Abstract：
:The recent discovery of a wide range of henipavirus-like viruses circulating in Megabats in Africa raises the question as to the zoonotic potential of these pathogens given the high human mortality rates seen with their pathogenic relatives Nipah virus and Hendra virus. In the absence of cultured infectious African Henipavirus we have performed experiments with recombinant F and G glycoproteins from the representative African Henipavirus strain M74a aimed at estimating its cellular tropism and capacity to use similar receptors to its highly pathogenic counterparts. The ability of the M74a virus G surface protein to use the ubiquitous Ephrin B2 host cell receptor and its heterologous cross-compatibility with Nipah virus could be expected to impart upon this virus a reasonable potential for species spillover, although differences in fusion efficiency seen with the M74a virus F protein in certain cell lines could present a barrier for zoonotic transmission.
journal_name
Virus Resjournal_title
Virus researchauthors
Lawrence P,Escudero Pérez B,Drexler JF,Corman VM,Müller MA,Drosten C,Volchkov Vdoi
10.1016/j.virusres.2014.01.003subject
Has Abstractpub_date
2014-03-06 00:00:00pages
77-80eissn
0168-1702issn
1872-7492pii
S0168-1702(14)00005-7journal_volume
181pub_type
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