Nucleotide sequence comparison of the M1 genome segment of reovirus type 1 Lang and type 3 Dearing.

Abstract:

:The mammalian reoviruses possess a genome composed of 10 double stranded RNA segments. The serotype 1 strain Lang M1 segment was sequenced and compared to the published type 3 sequence. Both segments were 2304 base-pairs long coding for the mu 2 protein predicted to be 736 amino acids long. The sequences were highly conserved with 97.2% conservation of nucleotide sequence and 98.6% conservation of amino acid sequence. The M1 segments of serotypes 1 and 3 have recently diverged as indicated by the distribution of variation with respect to codon positions. The conservation of amino acid sequence indicated that the mu 2 protein has a relatively high functional density.

journal_name

Virus Res

journal_title

Virus research

authors

Zou S,Brown EG

doi

10.1016/0168-1702(92)90042-8

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

159-64

issue

2

eissn

0168-1702

issn

1872-7492

pii

0168-1702(92)90042-8

journal_volume

22

pub_type

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