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Genetic and serotypic characterization of Sin Nombre-like viruses in Canadian Peromyscus maniculatus mice.

Abstract：

:In Canada, hantavirus infected deer mice (Peromyscus maniculatus) have been collected from British Columbia to Newfoundland. Partial sequencing of G1 and N protein encoding regions from Canadian Peromyscus maniculatus-borne hantaviruses demonstrated the existence of significant genotypic divergence among strains. Phylogenetic analysis showed that Sin Nombre (SN)-like viruses from eastern and western Canadian deer mice can be divided into at least two broad-based genogroups. Sequencing of mitochondrial DNA from infected deer mice originating from various eastern and western provinces showed that SN-like virus genogroups appeared to be associated with distinct haplotypes of mice. Sera from deer mice infected with eastern and western viral genotypes neutralized the Sin Nombre virus strain, Convict Creek 107, but not the New York 1 hantavirus. Despite the genetic heterogeneity of Canadian SN-like strains these hantaviruses do not appear to define unique hantavirus serotypes.

journal_name

Virus Res

journal_title

Virus research

authors

Drebot MA,Gavrilovskaya I,Mackow ER,Chen Z,Lindsay R,Sanchez AJ,Nichol ST,Artsob H

doi

10.1016/s0168-1702(01)00227-1

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

75-86

issue

1

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(01)00227-1

journal_volume

75

pub_type

杂志文章

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