Abstract：
:We determined the nucleotide sequence of a 3,811 base pair (bp) region of the bovine herpesvirus type-1 (BHV-1) HindIII-A fragment covering map units 0.429-0.456, which contained the HSV-1 homologues of the UL25, UL26 and UL26.5 genes. Sequence overlap was verified with previously published BHV-1 sequences, resulting in contiguous sequence spanning from UL24 to UL27 (encoding glycoprotein B). We found that the UL25 open reading frame (ORF) overlapped that of UL24 by 16 nucleotides, an unexpected feature based on previous herpesvirus sequences. We previously showed that the BHV-1 UL26 and UL26.5 genes encoded proteins that functioned in proteinase and scaffolding activity during capsid assembly, similar to the homologues in herpes simplex virus type-1. Northern blotting was used to map the four major transcripts from this region. As expected from the ORF analysis, the BHV-1 UL25 transcript initiated within the UL24 ORF. The BHV-1 UL24, UL25, UL26 and UL26.5 transcripts all terminated at a common 3'-polyadenylation site and varied significantly in their relative abundance.
journal_name
Virus Resjournal_title
Virus researchauthors
Haanes EJ,Chen CC,Lowery DEdoi
10.1016/s0168-1702(96)01420-7subject
Has Abstractpub_date
1997-04-01 00:00:00pages
19-26issue
1eissn
0168-1702issn
1872-7492pii
S0168-1702(96)01420-7journal_volume
48pub_type
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