Abstract：
:To examine the regulatory properties of feline immunodeficiency virus (FIV) long terminal repeat (LTR) integrated into host chromatin, Crandell feline kidney cells were stably transfected with the FIV LTR that directs the bacterial chloramphenicol acetyltransferase (CAT) gene. Using these cells, we examined the effects of treatment with several chemical agents, infection with feline viruses, or transfection with effector plasmids expressing FIV gene products on FIV LTR-directed gene expression. Among them, treatment with the phorbol ester (a strong activator of protein kinase C), forskolin (an inducer of cyclic-AMP), 5-azacytidine (a DNA methylation antagonist), or infection with feline herpesvirus type 1 (FHV-1), resulted in induction of CAT activity in the cells. These results suggest that the integrated FIV LTR is stimulated by cellular transcriptional factors induced by phorbol ester, forskolin and FHV-1, and is also inactivated by DNA methylation. Furthermore, this permanent cell line can be used as a screening system of activators of the FIV LTR.
journal_name
Virus Resjournal_title
Virus researchauthors
Ikeda Y,Kawaguchi Y,Tomonaga K,Inoshima Y,Kohmoto M,Miyazawa T,Mikami Tdoi
10.1016/0168-1702(96)01284-1subject
Has Abstractpub_date
1996-04-01 00:00:00pages
201-7issue
2eissn
0168-1702issn
1872-7492pii
0168170296012841journal_volume
41pub_type
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