Abstract：
:A recombinant baculovirus containing a cDNA which encodes haemagglutinin-neuraminidase (HN) of Newcastle disease virus (NDV) was constructed. Spodoptera frugiperda cells infected with this recombinant virus produced a large amount of HN glycoprotein similar to the authentic HN in size. The recombinant HN glycoprotein was localized on the surface of the infected cells and conserved its haemadsorption and neuraminidase activities. The antigenic properties of the recombinant HN glycoprotein seemed to be slightly different from the authentic one, as judging by the reactivity with a panel of monoclonal antibodies specific to the antigenic sites responsible for neutralization of viral infectivity. Chickens inoculated with the cells infected with the recombinant virus developed haemagglutination-inhibition and virus neutralization antibodies, and were completely protected from the NDV challenge.
journal_name
Virus Resjournal_title
Virus researchauthors
Niikura M,Matsuura Y,Hattori M,Onuma M,Mikami Tdoi
10.1016/0168-1702(91)90059-5subject
Has Abstractpub_date
1991-06-01 00:00:00pages
31-43issue
1eissn
0168-1702issn
1872-7492pii
0168-1702(91)90059-5journal_volume
20pub_type
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