Abstract：
:Human recombinant alpha interferon, A/D, significantly reduced the replication and cell fusion induced by herpes simplex virus type 1 in monkey cells. Thin-section electron microscopy of interferon-treated monkey cells showed distinct assembly of nucleocapsids within the nucleus. Analysis of virus-specific proteins by the immunoblot technique confirmed that A/D interferon had no significant effect on the expression of major nucleocapsid proteins, although the expression of glycoproteins B and D was reduced in interferon-treated cells. The possibility of an interferon-induced block at a late stage in virus morphogenesis is discussed.
journal_name
Virus Resjournal_title
Virus researchauthors
Chatterjee S,Whitley RJdoi
10.1016/0168-1702(89)90051-8subject
Has Abstractpub_date
1989-01-01 00:00:00pages
33-41issue
1eissn
0168-1702issn
1872-7492pii
0168-1702(89)90051-8journal_volume
12pub_type
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