Abstract：
:Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays critical roles in the regulation of many cellular processes including epigenetics, tumour suppression, oncogenesis, DNA damage response, immunity and viral infection. USP7 was the first DUB associated with viral infection. Since then other DUB:viral protein interactions have been discovered, however, USP7 continues to be the most targeted DUB interacting with many proteins from various viruses. The selective pressures of evolution have allowed viruses to develop mechanisms that subvert host cellular machinery, promoting survival of the viral niche. Numerous viral proteins have been identified to target and usurp the function of USP7 to their advantage. This review explores novel developments in research focusing on the mechanisms underlying the manipulation of USP7 by viruses.
journal_name
Virus Resjournal_title
Virus researchauthors
Bojagora A,Saridakis Vdoi
10.1016/j.virusres.2020.198076subject
Has Abstractpub_date
2020-09-01 00:00:00pages
198076eissn
0168-1702issn
1872-7492pii
S0168-1702(20)30141-6journal_volume
286pub_type
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