Abstract：
:The transforming potential of DNA tumor viruses derives mainly from the ability of their encoded oncogene products to interact with cellular proteins. Many of these viral oncoproteins share regions of sequence similarity, designated conserved region 1 and 2, which have been implicated in complex formation with pRb, the product of the retinoblastoma tumor suppressor gene, and related p107 and p130 species. It has now been shown that the EIA protein of adenovirus is able to bind to all three pRb-related proteins through sequences in conserved region 1 and 2. We have shown previously that polyomavirus large T-antigen also interacts with pRb and p107 in vitro. The pRb and p107 binding domains reside between residues 141, 158 which include conserved region 2. In the present study, we demonstrate that polyomavirus large T-antigen also interacted with p130 in vitro through the same sequences in conserved region 2.
journal_name
Virus Resjournal_title
Virus researchauthors
Desjardins P,Pilon AA,Hassell JA,Mes-Masson AMdoi
10.1016/s0168-1702(96)01404-9subject
Has Abstractpub_date
1997-01-01 00:00:00pages
85-90issue
1eissn
0168-1702issn
1872-7492pii
S0168170296014049journal_volume
47pub_type
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