当前位置： SCI文献检索 > VIRUS RESEARCH期刊下所有文献 > Attenuated live vaccine usage affects accurate measures of virus diversity and mutation rates in avian coronavirus infectious bronchitis virus.

Attenuated live vaccine usage affects accurate measures of virus diversity and mutation rates in avian coronavirus infectious bronchitis virus.

Abstract：

:The full-length genomes of 11 infectious bronchitis virus (IBV) field isolates from three different types of the virus; Massachusetts (Mass), Connecticut (Conn) and California (CAL) isolated over a 41, 25 and 8 year period respectively, were sequenced and analyzed to determine the mutation rates and level of polymorphisms across the genome. Positive selection was not detected and mutation rates ranged from 10(-4) to 10(-6)substitutions/site/year for Mass and Conn IBV types where attenuated live vaccines are routinely used to control the disease. In contrast, for CAL type viruses, for which no vaccine exists, positive selection was detected and mutation rates were 10 fold higher ranging from 10(-2) to 10(-3)substitutions/site/year. Lower levels of genetic diversity among the Mass and Conn viruses as well as sequence similarities with vaccine virus genomes suggest that the origin of the Mass and all but one of the Conn viruses was likely vaccine virus that had been circulating in the field for an unknown but apparently short period of time. The genetic data also identified a recombinant IBV isolate with 7 breakpoints distributed across the entire genome suggesting that viruses within the same serotype can have a high degree of genetic variability outside of the spike gene. These data are important because inaccurate measures of genetic diversity and mutation rates could lead to underestimates of the ability of IBV to change and potentially emerge to cause disease.

journal_name

Virus Res

journal_title

Virus research

authors

McKinley ET,Jackwood MW,Hilt DA,Kissinger JC,Robertson JS,Lemke C,Paterson AH

doi

10.1016/j.virusres.2011.04.006

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

225-34

issue

1-2

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(11)00142-0

journal_volume

158

pub_type

杂志文章

相关文献

VIRUS RESEARCH文献大全
  • Neutralization escape variant of West Nile virus associated with altered peripheral pathogenicity and differential cytokine profile.

    abstract：:In order to understand the factors influencing pathogenicity of a virus, two neutralization escape (NE) variants were selected from wild type lineage 1 West Nile virus (WNV) 68856 strain pathogenic by intra-peritoneal (i.p.) route using monoclonal antibodies (MAbs) against envelope (E) protein. Both NE IF1A7 1.1 and N...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2011.03.023

    authors： Sapkal GN,Harini S,Ayachit VM,Fulmali PV,Mahamuni SA,Bondre VP,Gore MM

    更新日期：2011-06-01 00:00:00

  • Antigenic diversity of Akabane virus detected by monoclonal antibodies.

    abstract：:The antigenic properties of 21 Japanese field isolates and two Australian strains of Akabane (AKA) virus (Simbu serogroup, bunyavirus) isolated from 1959 to 1990 were compared by enzyme-linked immunosorbent assay (ELISA), plaque-reduction neutralization (PRNT) and hemagglutination inhibition (HI) tests using monoclona...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(96)01415-3

    authors： Akashi H,Inaba Y

    更新日期：1997-02-01 00:00:00

  • Identification of a murine cell line that distinguishes virulent from attenuated isolates of the morbillivirus Peste des Petits Ruminants, a promising tool for virulence studies.

    abstract：:Comprehensive pathogenesis studies on Peste des Petits Ruminants virus (PPRV) have been delayed so far by the absence of a small animal model reproducing the disease or an in vitro biological system revealing virulence differences. In this study, a mouse 10T1/2 cell line has been identified as presenting different sus...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2020.198035

    authors： Comerlato J,Albina E,Puech C,Franco AC,Minet C,Eloiflin RJ,Rodrigues V,Servan de Almeida R

    更新日期：2020-09-01 00:00:00

  • Cold-passaged human parainfluenza type 3 viruses contain ts and non-ts mutations leading to attenuation in rhesus monkeys.

    abstract：:Cold-passaged (CP) mutants derived from the JS strain of wild type wt parainfluenza type 3 virus (PIV3) are being evaluated as candidate live virus vaccines. The wt virus was serially passaged 45 times at low temperature and mutant clones with the cold-adapted (CA), temperature-sensitive (ts), and attenuation (ATT) ph...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(92)90049-f

    authors： Hall SL,Stokes A,Tierney EL,London WT,Belshe RB,Newman FC,Murphy BR

    更新日期：1992-03-01 00:00:00

  • Encephalomyocarditis virus is potentially derived from eastern bent-wing bats living in East Asian countries.

    abstract：:Bats are reservoir hosts of many zoonotic viruses and identification of viruses that they carry is important. This study aimed to use high throughput screening to identify the viruses in fecal guano of Taiwanese insectivorous bats caves in order to obtain more information on bat-derived pathogenic viruses in East Asia...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2018.10.020

    authors： Doysabas KCC,Oba M,Furuta M,Iida K,Omatsu T,Furuya T,Okada T,Sutummaporn K,Shimoda H,Wong ML,Wu CH,Ohmori Y,Kobayashi R,Hengjan Y,Yonemitsu K,Kuwata R,Kim YK,Han SH,Sohn JH,Han SH,Suzuki K,Kimura J,Maeda K,O

    更新日期：2019-01-02 00:00:00

  • Infectious salmon anaemia virus nuclear export protein is encoded by a spliced gene product of genomic segment 7.

    abstract：:Infectious salmon anaemia virus (ISAV) is an orthomyxovirus causing anaemia and circulatory disease with high mortality in farmed Atlantic salmon (Salmo salar). Orthomyxoviruses are unusual as RNA viruses as they replicate in the nucleus and some viral transcripts undergo splicing. The nuclear replication necessitates...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2013.07.001

    authors： Ramly RB,Olsen CM,Braaen S,Rimstad E

    更新日期：2013-10-01 00:00:00

  • Complete genome sequence of a raccoon rabies virus isolate.

    abstract：:The entire genome of a mid-Atlantic raccoon strain rabies virus (RRV) isolated in Canada was sequenced; this is the second North American wildlife rabies virus isolate to be fully characterized. The overall organization and length of the genome was similar to that of other lyssaviruses. The nucleotide sequence identit...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2008.04.029

    authors： Szanto AG,Nadin-Davis SA,White BN

    更新日期：2008-09-01 00:00:00

  • The biology of beta human papillomaviruses.

    abstract：:The beta genus comprises more than 50 beta human papillomavirus (HPV) types that are suspected to be involved, together with ultraviolet (UV) irradiation, in the development of non-melanoma skin cancer (NMSC), the most common form of human cancer. Two members of the genus beta, HPV5 and HPV8, were first identified in ...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/j.virusres.2016.11.013

    authors： Tommasino M

    更新日期：2017-03-02 00:00:00

  • Porcine circovirus type 2 and its associated diseases in Korea.

    abstract：:This review describes the characterization of porcine circovirus type 2 (PCV2), the field situation of porcine circovirus-associated disease (PCVAD) and the PCV2 vaccine in Korea. PCVAD has been considered the most devastating disease in Korean livestock history since its first outbreak in 1999. Postweaning multisyste...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/j.virusres.2011.10.013

    authors： Chae C

    更新日期：2012-03-01 00:00:00

  • Molecular characterisation of Atlantic salmon paramyxovirus (ASPV): a novel paramyxovirus associated with proliferative gill inflammation.

    abstract：:Atlantic salmon paramyxovirus (ASPV) was isolated in 1995 from gills of farmed Atlantic salmon suffering from proliferative gill inflammation. The complete genome sequence of ASPV was determined, revealing a genome 16,968 nucleotides in length consisting of six non-overlapping genes coding for the nucleo- (N), phospho...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2008.01.006

    authors： Falk K,Batts WN,Kvellestad A,Kurath G,Wiik-Nielsen J,Winton JR

    更新日期：2008-05-01 00:00:00

  • Expression of antisense RNA fails to inhibit influenza virus replication.

    abstract：:Cell lines were constructed which permanently express influenza virus-specific RNA. Two approaches were followed. C127 cells were transformed with bovine papilloma virus (BPV) vectors and the resulting cell lines were found to inhibit the replication of influenza virus at low multiplicity of infection (MOI 0.05). Howe...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(89)90035-x

    authors： Leiter JM,Krystal M,Palese P

    更新日期：1989-10-01 00:00:00

  • Enhanced immune responses against Japanese encephalitis virus using recombinant adenoviruses coexpressing Japanese encephalitis virus envelope and porcine interleukin-6 proteins in mice.

    abstract：:Japanese encephalitis is a reproductive disorder caused by Japanese encephalitis virus (JEV) in swine. Previous studies have demonstrated that recombinant adenovirus serotype 5 (Ad5) may be a potential vaccine candidate because it can express JEV envelope epitopes and induce immune responses against JEV. Still, it wil...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2016.05.025

    authors： Liu H,Wu R,Liu K,Yuan L,Huang X,Wen Y,Ma X,Yan Q,Zhao Q,Wen X,Cao S

    更新日期：2016-08-15 00:00:00

  • Molecular epidemiology of rabies in Indonesia.

    abstract：:In order to clarify the genetic relationships and dynamics of rabies viruses that are epidemic in Indonesia, we determined and analyzed 1307 nucleotides of nucleoprotein genes of 34 rabies field isolates collected from Sumatra, Java, Kalimantan, Sulawesi and Flores islands. Results of phylogenetic analysis indicated t...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2008.03.001

    authors： Susetya H,Sugiyama M,Inagaki A,Ito N,Mudiarto G,Minamoto N

    更新日期：2008-07-01 00:00:00

  • Robust antiviral responses to enterovirus 71 infection in human intestinal epithelial cells.

    abstract：:Enterovirus 71 (EV71) is a single-stranded RNA virus that belongs to Picornaviridae family. It causes the hand-foot-and-mouth disease and fatal neurological diseases in young children and infants. The mechanism of EV71 pathogenesis remains obscure. The intestinal tract is the initial site of EV71 replication, but no o...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2013.05.002

    authors： Chi C,Sun Q,Wang S,Zhang Z,Li X,Cardona CJ,Jin Y,Xing Z

    更新日期：2013-09-01 00:00:00

  • Identification in the sera from patients with advanced cancer of a factor which stimulates gene expression from human immunodeficiency virus type 1.

    abstract：:From the sera of patients with advanced cancer, a novel factor called SDF (serum-derived factor) was partially purified. SDF was shown to stimulate transcription from the long terminal repeat (LTR) of human immunodeficiency virus type 1 (HIV-1) by transient CAT assay. It did not stimulate gene expression of various co...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(93)90065-u

    authors： Ogiwara H,Nakamura T,Baba S,Okamoto T

    更新日期：1993-09-01 00:00:00

  • Rabies virus replication induces Bax-related, caspase dependent apoptosis in mouse neuroblastoma cells.

    abstract：:Rabies virus has been shown to induce apoptosis in infected cells, but the intracellular pathway of cell killing is unknown. In this report, we show that rabies virus infected mouse neuroblastoma cells underwent chromatin condensation and DNA fragmentation within 48 h post-infection. An increased level of the apoptoti...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(98)00078-1

    authors： Ubol S,Sukwattanapan C,Utaisincharoen P

    更新日期：1998-08-01 00:00:00

  • Risk factors associated with increased bovine leukemia virus proviral load in infected cattle in Japan from 2012 to 2014.

    abstract：:Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis, a malignant B cell lymphoma. BLV has spread worldwide and causes serious problems. After infection, the BLV genome is integrated into the host DNA and can be amplified during periods of latency. We previously designed degenerate primers us...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2015.08.020

    authors： Ohno A,Takeshima SN,Matsumoto Y,Aida Y

    更新日期：2015-12-02 00:00:00

  • New developments in tracing neural circuits with herpesviruses.

    abstract：:Certain neurotropic viruses can invade the nervous system of their hosts and spread in chains of synaptically connected neurons. Consequently, it is possible to identify entire hierarchically connected circuits within an animal. In this review, we discuss the use of neurotropic herpesviruses as neuronal tract tracers....

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/j.virusres.2005.04.012

    authors： Song CK,Enquist LW,Bartness TJ

    更新日期：2005-08-01 00:00:00

  • Evidence of a major role of GP64 in group I alphabaculovirus evolution.

    abstract：:Previous investigations suggest that the divergence of the group I alphabaculoviruses was later than that of the group II alphabaculoviruses, however, there is no quantitative data to support this hypothesis. To examine this theory, the evolutionary rates of the 30 core genes that are conserved among all baculoviruses...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2009.01.015

    authors： Jiang Y,Deng F,Rayner S,Wang H,Hu Z

    更新日期：2009-06-01 00:00:00

  • Mutations in the HRB linker of human parainfluenza virus type 3 fusion protein reveal its importance for fusion activity.

    abstract：:Human parainfluenza virus type 3 (HPIV3) fuses the viral envelope with the host cell membrane through the concerted action of the fusion (F) protein and the hemagglutinin-neuraminidase (HN). Upon HN binding to sialic acid (SA), the F protein in a metastable prefusion form is activated to undergo a series of structural...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2019.197791

    authors： Liu Y,Xie W,Chi M,Wen H,Zhao L,Song Y,Liu N,Chi L,Wang Z

    更新日期：2020-01-02 00:00:00

  • Identification of a protein encoded in the herpes simplex virus type 1 latency associated transcript promoter region.

    abstract：:Herpes simplex virus type 1 (HSV-1) establishes a lifelong latency in the neurons of its host. Sporadically, the latent virus reactivates and spreads back to the original site of infection and causes recrudescent diseases. The only gene actively transcribed during neuronal latency is the latency associated transcript ...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2004.08.011

    authors： Naito J,Mukerjee R,Mott KR,Kang W,Osorio N,Fraser NW,Perng GC

    更新日期：2005-03-01 00:00:00

  • A century of plant virus management in the Salinas valley of California, 'East of Eden'.

    abstract：:The mild climate of the Salinas Valley, CA lends itself well to a diverse agricultural industry. However, the diversity of weeds, crops and insect and fungal vectors also provide favorable conditions for plant virus disease development. This paper considers the incidence and management of several plant viruses that ha...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-1702(00)00196-9

    authors： Wisler GC,Duffus JE

    更新日期：2000-11-01 00:00:00

  • The evolution of subtype B HIV-1 tat in the Netherlands during 1985-2012.

    abstract：:For the production of viral genomic RNA, HIV-1 is dependent on an early viral protein, Tat, which is required for high-level transcription. The quantity of viral RNA detectable in blood of HIV-1 infected individuals varies dramatically, and a factor involved could be the efficiency of Tat protein variants to stimulate...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2018.04.008

    authors： van der Kuyl AC,Vink M,Zorgdrager F,Bakker M,Wymant C,Hall M,Gall A,Blanquart F,Berkhout B,Fraser C,Cornelissen M,BEEHIVE Collaboration.

    更新日期：2018-05-02 00:00:00

  • Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein.

    abstract：:Hepatitis C virus (HCV) is a modern-day pandemic; 2-3% of the world's population are thought to be infected with the virus and are subsequently at risk of developing end-stage liver diseases. The traditional standard of care (SOC) for HCV-infected patients has been limited to a regimen of pegylated-interferon alpha (p...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/j.virusres.2012.09.007

    authors： Belda O,Targett-Adams P

    更新日期：2012-12-01 00:00:00

  • SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.

    abstract：:Transcription of human immunodeficiency virus (HIV-1) is activated by viral Tat protein which regulates HIV-long terminal repeat (LTR) transcription and elongation. HIV-1 Tat protein is a substrate for the deacetylase activity of sirtuin 1 (SIRT1). Here we investigate the signaling pathway involved in Tat-induced HIV-...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2009.08.005

    authors： Zhang HS,Wu MR

    更新日期：2009-12-01 00:00:00

  • Polyomavirus large T-antigen binds the "pRb related' protein p130 through sequences in conserved region 2.

    abstract：:The transforming potential of DNA tumor viruses derives mainly from the ability of their encoded oncogene products to interact with cellular proteins. Many of these viral oncoproteins share regions of sequence similarity, designated conserved region 1 and 2, which have been implicated in complex formation with pRb, th...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(96)01404-9

    authors： Desjardins P,Pilon AA,Hassell JA,Mes-Masson AM

    更新日期：1997-01-01 00:00:00

  • Development of a novel DNA-launched dengue virus type 2 infectious clone assembled in a bacterial artificial chromosome.

    abstract：:Major progress in Dengue virus (DENV) biology has resulted from the use of infectious clones obtained through reverse genetics. The construction of these clones is commonly based on high- or low-copy number plasmids, yeast artificial chromosomes, yeast-Escherichia coli shuttle vectors, and bacterial artificial chromos...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2013.12.001

    authors： Usme-Ciro JA,Lopera JA,Enjuanes L,Almazán F,Gallego-Gomez JC

    更新日期：2014-02-13 00:00:00

  • Evasion of host immunity directed by papillomavirus-encoded proteins.

    abstract：:The nature of the interaction between papillomaviruses (PV) and their infected host has led to the identification of ways in which the viral oncoproteins can transform the infected host cells into cancer cells. As viral persistence is required for malignancy, and persistence requires avoidance of immune attack by the ...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-1702(02)00123-5

    authors： O'Brien PM,Saveria Campo M

    更新日期：2002-09-01 00:00:00

  • Differential susceptibility of resting CD4(+) T lymphocytes to a T-tropic and a macrophage (M)-tropic human immunodeficiency virus type 1 is associated with their surface expression of CD38 molecules.

    abstract：:Recent evidence has accumulated which definitively shows that chemokine receptors CCR5 and CXCR4 play an essential role as coreceptors for human immunodeficiency virus type 1 (HIV-1) infection. Flow cytometric analysis permitted us to detect CD38, a surface marker of early differentiation, as well as activation of T c...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(00)00220-3

    authors： Horikoshi H,Kinomoto M,Sasao F,Mukai T,Luftig RB,Ikuta K

    更新日期：2001-01-01 00:00:00

  • Giant viruses as protein-coated amoeban mitochondria?

    abstract：:Mimivirus' genome includes parts of 5S, 16S and 23S ribosomal RNAs encoded by Acanthamoeba's mitogenome, the giant virus' host. Two non-exclusive hypotheses for rRNA remnants in giant viruses are examined: 1. mitogenomes invade viral genomes as they do for nuclear chromosomes (producing numts); 2. megaviral genomes ev...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2018.06.004

    authors： Seligmann H

    更新日期：2018-07-15 00:00:00