Abstract:
:We have rescued a transfectant influenza virus, NA/TAIL(-), whose neuraminidase (NA) protein lacks the predicted cytoplasmic tail. The virus was attenuated (one log10 reduction) both in tissue culture and in mouse lungs. Attenuation correlated with a 50% reduction of the level of NA in infected cells and levels of incorporation of the tail-less NA protein into viral particles paralleled that in infected cells. This result indicates that the signal for packaging of the NA protein into the viral envelope is not located in its cytoplasmic domain.
journal_name
Virus Resjournal_title
Virus researchauthors
García-Sastre A,Palese Pdoi
10.1016/0168-1702(95)00017-ksubject
Has Abstractpub_date
1995-06-01 00:00:00pages
37-47issue
1eissn
0168-1702issn
1872-7492pii
016817029500017Kjournal_volume
37pub_type
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