Abstract：
:Caprine herpesvirus 1 (CpHV-1) is responsible of systemic infection in neonatal kids as well as abortion and fertility disorders in adult goats. This virus is closely related to bovine herpesvirus 1 (BoHV-1) which causes infectious bovine rhinotracheitis. Glycoprotein D (gD) mediates important functions in alphaherpesviruses and is also a main immunogen. The sequence of CpHV-1 gD gene and the biochemical properties of its translation product were analyzed and compared to those of BoHV-1 and other alphaherpesviruses. A relatively high homology was found between CpHV-1 and BoHV-1 glycoproteins D amino acid sequences (similarity of 68.8%). Moreover, six cysteine residues are conserved by CpHV-1 gD and the other studied alphaherpesviruses. CpHV-1 gD has a molecular mass similar to BoHV-1 gD and contains complex N-linked oligosaccharides. In contrast to the BoHV-1 gD, CpHV-1 gD is expressed as a late protein. In spite of the observed differences which could influence its biological functions, CpHV-1 gD shares most characteristics with other alphaherpesviruses and especially BoHV-1.
journal_name
Virus Resjournal_title
Virus researchauthors
Keuser V,Detry B,Thiry J,de Fays K,Schynts F,Pastoret PP,Vanderplasschen A,Thiry Edoi
10.1016/j.virusres.2005.07.009subject
Has Abstractpub_date
2006-02-01 00:00:00pages
112-21issue
2eissn
0168-1702issn
1872-7492pii
S0168-1702(05)00236-4journal_volume
115pub_type
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