Abstract：
:In situ hybridization and virus titration were used to characterize early stages of rat virus (RV) infection of rat pups after oronasal inoculation. Results suggest that virus enters through the lung and that early viremia leads rapidly to pantropic infection. Cells derived from all three germ layers were infected with RV, but those of endodermal and mesodermal origin were the predominant targets. Infection of vascular endothelium was widespread and was associated with hemorrhage and infarction in the brain. Convalescence from acute infection was accompanied by mononuclear cell infiltrates at sites containing RV DNA. Viral DNA was also detected in endothelium, fibroblasts and smooth muscle myofibers four weeks after inoculation. Further examination of these cells as potential sites of persistent infection is warranted.
journal_name
Virus Resjournal_title
Virus researchauthors
Gaertner DJ,Jacoby RO,Johnson EA,Paturzo FX,Smith AL,Brandsma JLdoi
10.1016/0168-1702(93)90085-2subject
Has Abstractpub_date
1993-04-01 00:00:00pages
1-18issue
1eissn
0168-1702issn
1872-7492pii
0168-1702(93)90085-2journal_volume
28pub_type
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