Abstract：
:Influenza virus rgVac1sub-P0 (H5N1) (rgVac1-P0), in which a pair of dibasic amino acid residues was introduced at the cleavage site of the HA of a reassortant of H5N2 and H7N1 viruses of duck origin, was low pathogenic in chickens. Vac1sub-P3 (H5N1) (Vac1-P3) was selected as a highly pathogenic avian influenza virus by 3 consecutive passages in chickens from low pathogenic strain rgVac1-P0. Comparison of amino acid sequences of the virus proteins and experimental infection of chickens with a series of recombinant viruses demonstrated that in addition to the HA, each of the PA, NP, M1, and M2 of Vac1-P3 are responsible for the acquisition of pathogenicity in chickens. These 4 proteins of Vac1-P3 synergistically contributed to efficient virus replication in chickens.
journal_name
Virus Resjournal_title
Virus researchauthors
Yamamoto N,Soda K,Sakoda Y,Okamatsu M,Kida Hdoi
10.1016/j.virusres.2013.02.001subject
Has Abstractpub_date
2013-05-01 00:00:00pages
294-8issue
2eissn
0168-1702issn
1872-7492pii
S0168-1702(13)00050-6journal_volume
173pub_type
杂志文章相关文献
VIRUS RESEARCH文献大全abstract：:We selected Chinese hamster ovary (CHO) cell-adapted strains of human enterovirus 71 (HEV71) belonging to sub-genogroups B5 (HEV71-B5) and C2 (HEV71-C2) by serial passage in CHO cells at a high multiplicity of infection. During the course of CHO cell passage, virus growth improved significantly, with increasing virus ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2012.02.009
更新日期：2012-05-01 00:00:00
abstract：:Genome sequencing and analysis of snake adenovirus type 1 (SnAdV-1), originating from corn snake, were completed. This is the first full genomic sequence of an adenovirus from reptilian hosts. The presence of characteristic genus-common genes and transcription units, showed that SnAdV-1 shares similar genome organisat...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2007.11.009
更新日期：2008-03-01 00:00:00
abstract：:The ultrastructure of the equine morbillivirus (EMV) which was implicated in the death of one human and fourteen horses in Queensland, Australia during September 1994 and a 36 year old man from Queensland in October 1995 is described. The ultrastructure of the virus and the intracellular virus-specific structures are ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(96)01307-x
更新日期：1996-07-01 00:00:00
abstract：:Noncoding RNAs (ncRNAs) are key components of the transcriptome and play an important role in both normal biological activity and pathological processes such as viral infection and tumorigenesis. LncRNAs and miRNAs are the most important elements of ncRNAs and function as vital regulatory elements. Their complex regul...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2018.08.018
更新日期：2018-09-15 00:00:00
abstract：:It was previously reported that during serial passage of a BHK-derived cell line persistently infected with foot-and-mouth disease virus, (termed C1-BHK-Rc1) the virus became increasingly more virulent for BHK-21 cells (de la Torre et al 1988). Virus strains isolated from different cell passage levels were tested for ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(90)90084-o
更新日期：1990-12-01 00:00:00
abstract：:To determine the pathogenicity domain and to apply cross protection, Pepper mild mottle virus (PMMoV) point-mutations in the replicase (REP) gene between the methyl-transferase and helicase domains, and deletions truncating pseudoknots in the 3' non-coding region (NCR), were constructed. Some mutants substituting a si...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2005.11.004
更新日期：2006-06-01 00:00:00
abstract：:The transforming potential of DNA tumor viruses derives mainly from the ability of their encoded oncogene products to interact with cellular proteins. Many of these viral oncoproteins share regions of sequence similarity, designated conserved region 1 and 2, which have been implicated in complex formation with pRb, th...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(96)01404-9
更新日期：1997-01-01 00:00:00
abstract：:St. Louis encephalitis virus (SLEV), a flavivirus transmitted to humans by Culex mosquitoes, causes clinical symptoms ranging from acute febrile disorder to encephalitis. To reach the central nervous system (CNS) from circulating blood, the pathogen must cross the blood-brain barrier formed by endothelial cells and as...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2016.03.005
更新日期：2016-06-02 00:00:00
abstract：:Raccoons (Procyon lotor), which are not native to Japan, have been suspected to transmit various pathogens by frequent intrusion into agricultural and residential areas. To determine influenza A virus seropositivity in raccoons in Japan, we examined a total of 634 raccoons captured in 19 towns (A-S) from 2009 to 2012....
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.05.004
更新日期：2014-08-30 00:00:00
abstract：:The positive sense genomes of members of the genus Flavivirus in the family Flaviviridae are ∼ 11 kb in length and have a 5' type I cap but no 3' poly-A. The 3' and 5' terminal regions contain short conserved sequences that are proposed to be repeated remnants of an ancient sequence. However, the functions of most of ...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2015.02.006
更新日期：2015-08-03 00:00:00
abstract：:Fourteen isolates of bovine herpesvirus 1 (BHV-1) found representative of more than 100 isolates studied, were compared by restriction fragment pattern analyses and molecularly characterized. A number of evolutionary links between the variants originally associated with infectious bovine rhinotracheitis and the varian...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(96)01383-4
更新日期：1996-12-01 00:00:00
abstract：:Viruses have evolved unique strategies and mechanisms to recruit ribosomes to ensure continued translation of their viral RNA during infection. The Dicistroviridae family of invertebrate viruses contains an unusual internal ribosome entry site (IRES), which can directly recruit ribosomes in the absence of initiation f...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2005.10.011
更新日期：2006-07-01 00:00:00
abstract：:JCPyV and BKPyV are common human polyomaviruses that cause lifelong asymptomatic persistent infections in their hosts. In immunosuppressed individuals, increased replication of JCPyV and BKPyV cause significant disease. JCPyV causes a fatal and rapidly progressing demyelinating disease known as progressive multifocal ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.06.008
更新日期：2014-08-30 00:00:00
abstract：:Major progress in Dengue virus (DENV) biology has resulted from the use of infectious clones obtained through reverse genetics. The construction of these clones is commonly based on high- or low-copy number plasmids, yeast artificial chromosomes, yeast-Escherichia coli shuttle vectors, and bacterial artificial chromos...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.12.001
更新日期：2014-02-13 00:00:00
abstract：:We have investigated the infection of Aedes albopictus (mosquito) cell clones by Sindbis virus. Variation in the multiplicity of infection (MOI) from ranges of 50-0.00005 pfu/cell was determined to have no effect on the progression of the infection to high acute phase titer, suggesting that intracellular factors alone...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(97)01461-5
更新日期：1997-07-01 00:00:00
abstract：:Herpesvirus, such as herpes simplex type 1 (HSV-1) acquire their envelope by budding through a modified inner membrane of the nuclear envelope which forms thick and dense patches at the site of budding. This suggests that some of the viral envelope glycoproteins must be transported to the nuclear envelope in order to ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(93)90023-g
更新日期：1993-06-01 00:00:00
abstract：:Rosellinia necatrix is responsible for the white rot root disease of avocado in Southern Spain. Entoleuca sp. is a fungus isolated from roots of these same trees, but it is not pathogenic in avocado. Here, we describe two new species of partitiviruses detected in isolates of the avocado sympatric fungi Entoleuca sp. a...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2020.198020
更新日期：2020-08-01 00:00:00
abstract：:Orf virus infection causes a contagious pustular dermatitis characterized by extensive vascular changes that have been linked to a virally encoded vascular endothelial growth factor (VEGF). The VEGF genes of different strains of orf virus can vary extensively in amino acid sequence. Functional analyses of two major va...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2007.04.018
更新日期：2007-09-01 00:00:00
abstract：:White spot syndrome virus immediate early (IE) gene wsv249 encodes an E3 ubiquitin ligase that can interact with a shrimp ubiquitin-conjugating enzyme to mediate ubiquitination. In this study, to understand the transcriptional regulation of wsv249, a serial of 5'-truncated mutations were made on its promoter and the a...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2018.05.012
更新日期：2018-07-02 00:00:00
abstract：:A cell-free system was developed to study the replication of simian rotavirus SA11. The components of the system included (i) subviral particles prepared from infected cells to template the synthesis of viral RNA and (ii) an mRNA-dependent rabbit reticulocyte lysate to support protein synthesis. Based upon nuclease-se...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(86)90071-7
更新日期：1986-12-01 00:00:00
abstract：:Bovine herpesvirus-1 infected cell protein 27 (BICP27) was detected predominantly in the nucleolus. The open reading frame of BICP27 was fused with the enhanced yellow fluorescent protein (EYFP) gene to investigate its subcellular localization in live cells and BICP27 was able to direct monomeric, dimeric or trimeric ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.07.024
更新日期：2009-11-01 00:00:00
abstract：:Picobirnaviruses possess a bisegmented double-stranded RNA genome. While the segment 2 encodes the RNA-dependent RNA polymerase, the segment 1 displays two open reading frames (ORFs). ORF2 was recently shown to code the capsid precursor and ORF1 product has not been characterized. In this study, we show that the three...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2011.02.018
更新日期：2011-06-01 00:00:00
abstract：:Previous investigations suggest that the divergence of the group I alphabaculoviruses was later than that of the group II alphabaculoviruses, however, there is no quantitative data to support this hypothesis. To examine this theory, the evolutionary rates of the 30 core genes that are conserved among all baculoviruses...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.01.015
更新日期：2009-06-01 00:00:00
abstract：:Mouse hepatitis virus (MHV) nucleocapsid (N) protein binds to the large, single-stranded, positive-sense viral genomic RNA to form a helical nucleocapsid structure in mature virions. In addition N protein binds the intracellular form of the genomic RNA, all of the MHV subgenomic mRNAs, and expressed non-MHV RNA transc...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2003.08.021
更新日期：2003-12-01 00:00:00
abstract：:The cDNA of the nucleocapsid (core) protein of classical swine fever virus (CSFV) was generated by reverse transcription-polymerase chain reaction (RT-PCR) and cloned into a eukaryotic expression vector. The effect of the recombinant core protein on the transcriptional regulation of cellular as well as viral promoters...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(97)00132-9
更新日期：1998-01-01 00:00:00
abstract：:An Olive latent virus 1 isolate designated GM6, obtained from a Portuguese olive tree, was characterized and the coat protein gene sequenced and analysed. The purified virus particles showed to be isometric with ca. 30 nm in diameter and contained a single-stranded RNA species with ca. 3.7 kb. The dsRNA profile obtain...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2004.09.007
更新日期：2005-03-01 00:00:00
abstract：:Influenza A viruses are characterized by a unique genome structure, causing genetic instability, especially to the genes of haemagglutinin and neuraminidase. The objectives of this research was molecular and phylogenetic analysis of influenza A(H3N2) strains that circulated in Northern Greece since 2004, particularly ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.07.006
更新日期：2009-11-01 00:00:00
abstract：:Viruses and virus-like particles (VLPs) of insect parasitoids modify host-parasite interactions. The Drosophila wasp, Leptopilina heterotoma, produce 300 nm spiked VLPs that bind to the host's blood cells via surface projections. L. heterotoma is a generalist wasp that attacks over a dozen Drosophila species. Oviposit...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2011.06.005
更新日期：2011-09-01 00:00:00
abstract：:Confocal microscopy revealed that Rice dwarf virus (RDV) initially accumulated in epithelial cells of the filter chamber of leafhopper vector Nephotettix cincticeps 2 days after acquisition access feeding on diseased plants. Subsequently, RDV accumulation progressed to the anterior midgut, and then spread to the nervo...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2011.04.028
更新日期：2011-09-01 00:00:00
abstract：:Application of bacteriophages and their lytic enzymes to control Clostridium perfringens is one potential approach to reduce the pathogen on poultry farms and in poultry-processing facilities. Bacteriophages lytic for C. perfringens were isolated from sewage, feces and broiler intestinal contents and ΦCPV1, a virulent...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2010.11.012
更新日期：2011-02-01 00:00:00
