Abstract：
:The ultrastructure of the equine morbillivirus (EMV) which was implicated in the death of one human and fourteen horses in Queensland, Australia during September 1994 and a 36 year old man from Queensland in October 1995 is described. The ultrastructure of the virus and the intracellular virus-specific structures are characteristic for the family Paramyxoviridae. Cytoplasmic nucleocapsids were observed within the infected cells monolayers, endothelial cells (lung) of infected horses and the neurons within the brain of the 36 year old Queensland man. Aggregates of smaller nucleocapsid-like structures were also observed within the brain of the same man; these did not react with sera from recovered EMV-infected horses or from a recovered EMV-infected human. Co-examination of rinderpest virus (RPV), bovine parainfluenza-3 (BPIV-3), human respiratory virus (HRSV) and Sendai virus revealed that their envelope-associated surface projections are equivalent in length to the 15 nm spikes of EMV. EMV differed from these other viruses in that the majority of virions possessed surface projections of two distinct lengths (18 and 15 nm). Further ultrastructural examinations of plaque purified EMV revealed a small percentage of EM viruses possessed a mixed array of surface projections indicating that the 'double-fringed' (DF) particles may be the result of a post-translational modification(s).
journal_name
Virus Resjournal_title
Virus researchauthors
Hyatt AD,Selleck PWdoi
10.1016/0168-1702(96)01307-xsubject
Has Abstractpub_date
1996-07-01 00:00:00pages
1-15issue
1eissn
0168-1702issn
1872-7492pii
016817029601307Xjournal_volume
43pub_type
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