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Increase of virus yields and releases of Borna disease virus from persistently infected cells.

Abstract：

:Borna disease virus grows to low titres in persistently infected cells with an infectious particle to cell ratio of 0.01 to 0.05. Inclusion of n-butyrate in the growth medium enhances infectivity yields up to 1 log. This effect is time and concentration dependent. In hypertonic medium with an excess of NaCl, KCl or Na2SO4 up to 50% of the total infectious virus yield is released from the cells. Released supernatant virus (buoyant density in sucrose rho = 1.22 g/cm3) is more heat stabile than cell-bound virus (rho = 1.18 g/cm3). The access to cell-free (released) virus opens new possibilities for the characterization of this neurotropic agent.

journal_name

Virus Res

journal_title

Virus research

authors

Pauli G,Ludwig H

doi

10.1016/0168-1702(85)90057-7

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

29-33

issue

1

eissn

0168-1702

issn

1872-7492

pii

0168-1702(85)90057-7

journal_volume

2

pub_type

杂志文章

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