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Inhibition of Theiler's virus-induced apoptosis in infected murine macrophages results in necroptosis.

Abstract：

:In mice Theiler's murine encephalomyelitis virus (TMEV) persists in macrophages that eventually undergo apoptosis. TMEV infection of macrophages in culture induces apoptosis through the intrinsic pathway, restricting virus yields. We show that inhibition of TMEV-induced apoptosis leads to phosphorylation of receptor interacting protein 1 (RIP1), localization of RIP1 and RIP3 to mitochondria, ROS production independent of MAPK activation and programmed necrosis (necroptosis). Blocking both apoptosis and necroptosis restored virus yields.

journal_name

Virus Res

journal_title

Virus research

authors

Son KN,Lipton HL

doi

10.1016/j.virusres.2014.10.017

subject

Has Abstract

pub_date

2015-01-02 00:00:00

pages

177-82

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(14)00422-5

journal_volume

195

pub_type

杂志文章

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