Abstract：
:Recent X-ray crystal structure determinations of Moloney murine leukemia virus reverse transcriptase (MoMLV RT) have allowed for more accurate structure/function comparisons to HIV-1 RT than were formerly possible. Previous biochemical studies of MoMLV RT in conjunction with knowledge of sequence homologies to HIV-1 RT and overall fold similarities to RTs in general, provided a foundation upon which to build. In addition, numerous crystal structures of the MoMLV RT fingers/palm subdomain had also shed light on one of the critical functions of the enzyme, specifically polymerization. Now in the advent of new structural information, more intricate examination of MoMLV RT in its entirety can be realized, and thus the comparisons with HIV-1 RT may be more critically elucidated. Here, we will review the similarities and differences between MoMLV RT and HIV-1 RT via structural analysis, and propose working models for the MoMLV RT based upon that information.
journal_name
Virus Resjournal_title
Virus researchauthors
Coté ML,Roth MJdoi
10.1016/j.virusres.2008.01.001subject
Has Abstractpub_date
2008-06-01 00:00:00pages
186-202issue
1-2eissn
0168-1702issn
1872-7492pii
S0168-1702(08)00005-1journal_volume
134pub_type
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