当前位置： SCI文献检索 > VIRUS RESEARCH期刊下所有文献 > The immune response to measles virus in mice. T-helper response to the nucleoprotein and mapping of the T-helper epitopes.

The immune response to measles virus in mice. T-helper response to the nucleoprotein and mapping of the T-helper epitopes.

Abstract：

:The T-helper response to the measles virus nucleoprotein (NP) has been studied in mice. The T-cell proliferative response was measured in lymphocytes from mice immunized with either a vaccinia measles-NP recombinant virus or a mouse neuro-adapted measles virus. A T-cell response was obtained with lymphocytes from H2d or H2k mice when stimulated with either measles virus or the NP expressed in bacteria. The response was CD4+ specific. The T-helper epitopes were mapped using truncated NP peptides. The major epitopes in both H2d and H2k mice were determined to be between amino acids 67-98. A further T-cell epitope (between amino acids 457-525) was identified when H2d mice were immunized with measles virus. Studies to quantitate the precursor cells for these epitopes confirmed that the region 67-98 of NP was immunodominant in both haplotypes immunized with the vaccinia-NP recombinant virus, whereas an additional major epitope was observed in the measles virus-infected H2d mice. The primary structure of the epitopes determined here are compared to predicted T-cell epitope motifs.

journal_name

Virus Res

journal_title

Virus research

authors

Giraudon P,Buckland R,Wild TF

doi

10.1016/0168-1702(92)90088-q

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

41-54

issue

1

eissn

0168-1702

issn

1872-7492

pii

0168-1702(92)90088-Q

journal_volume

22

pub_type

杂志文章

相关文献

VIRUS RESEARCH文献大全
  • Prevalence of multiple subtypes of influenza A virus in Japanese wild raccoons.

    abstract：:Raccoons (Procyon lotor), which are not native to Japan, have been suspected to transmit various pathogens by frequent intrusion into agricultural and residential areas. To determine influenza A virus seropositivity in raccoons in Japan, we examined a total of 634 raccoons captured in 19 towns (A-S) from 2009 to 2012....

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2014.05.004

    authors： Yamaguchi E,Sashika M,Fujii K,Kobayashi K,Bui VN,Ogawa H,Imai K

    更新日期：2014-08-30 00:00:00

  • Glycoprotein C of equine herpesvirus 4 plays a role in viral binding to cell surface heparan sulfate.

    abstract：:Heparan sulfate moieties of cell surface proteoglycans serve as receptors for several herpesviruses. For herpes simplex virus 1, pseudorabies virus and equine herpesvirus 1, glycoprotein C (gC) homologues have been shown to mediate the binding to cell surface heparan sulfate. However, the role of gC in equine herpesvi...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2010.03.003

    authors： Azab W,Tsujimura K,Maeda K,Kobayashi K,Mohamed YM,Kato K,Matsumura T,Akashi H

    更新日期：2010-07-01 00:00:00

  • Poliovirus Receptor: More than a simple viral receptor.

    abstract：:The human poliovirus receptor (PVR) is a cell surface protein with a multitude of functions in human biology. PVR was initially identified as the receptor for the human poliovirus and recent discoveries have given a greater insight into both its morphology and its function. Alternative splicing of the PVR gene results...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/j.virusres.2017.09.001

    authors： Bowers JR,Readler JM,Sharma P,Excoffon KJDA

    更新日期：2017-10-15 00:00:00

  • Identification of novel functional regions within the spike glycoprotein of MHV-A59 based on a bioinformatics approach.

    abstract：:Mouse Hepatitis Virus (MHV) is a single-stranded positive sense RNA virus with the ability to promote acute and chronic diseases in mice. The MHV spike protein (S) is a major virulence determinant which in addition to binding to cellular receptors to mediate cell entry and facilitate virus spread to adjacent cells by ...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2014.05.023

    authors： Kaufman G,Liu P,Leibowitz JL

    更新日期：2014-08-30 00:00:00

  • Hypermethylated levels of E-cadherin promoter in Huh-7 cells expressing the HCV core protein.

    abstract：BACKGROUND AND AIM:The mechanisms of hepatocarcinogenesis induced by hepatitis C virus remain unclear. Our aim was to investigate the effect of the HCV core protein on the promoter methylation status of selected genes potentially involved in the hepatocellular carcinoma (HCC). MATERIALS AND METHODS:We evaluated the pr...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2011.05.014

    authors： Ripoli M,Barbano R,Balsamo T,Piccoli C,Brunetti V,Coco M,Mazzoccoli G,Vinciguerra M,Pazienza V

    更新日期：2011-09-01 00:00:00

  • Characterization of significant molecular determinants of virulence of Enterovirus 71 sub-genotype B4 in Rhabdomyosarcoma cells.

    abstract：:One of the leading causes of the hand, foot and mouth disease (HFMD) is Enterovirus 71 (EV-A71), displaying symptoms such as fever and ulcers in children but some strains can produce cardiopulmonary oedema which leads to death. There is no FDA-approved vaccine for prevention of severe HFMD. The molecular determinants ...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2017.07.010

    authors： Yee PTI,Mohamed RAH,Ong SK,Tan KO,Poh CL

    更新日期：2017-06-15 00:00:00

  • Current approaches to the development of vaccines effective against parainfluenza and respiratory syncytial viruses.

    abstract：:Vaccines against parainfluenza (PIV) and respiratory syncytial viruses (RSV) that are currently being developed include both live and subunit vaccines. Candidate live PIV vaccines that have been found to be attenuated and efficacious in rodents or primate models are (1) cold-adapted, temperature-sensitive mutants of P...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/0168-1702(88)90063-9

    authors： Murphy BR,Prince GA,Collins PL,Van Wyke Coelingh K,Olmsted RA,Spriggs MK,Parrott RH,Kim HW,Brandt CD,Chanock RM

    更新日期：1988-08-01 00:00:00

  • The recombinant nucleocapsid protein of classical swine fever virus can act as a transcriptional regulator.

    abstract：:The cDNA of the nucleocapsid (core) protein of classical swine fever virus (CSFV) was generated by reverse transcription-polymerase chain reaction (RT-PCR) and cloned into a eukaryotic expression vector. The effect of the recombinant core protein on the transcriptional regulation of cellular as well as viral promoters...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(97)00132-9

    authors： Liu JJ,Wong ML,Chang TJ

    更新日期：1998-01-01 00:00:00

  • DNA sequence of the simian varicella virus (SVV) gH gene and analysis of the SVV and varicella zoster virus gH transcripts.

    abstract：:The varicella zoster virus (VZV) glycoprotein H (gH) stimulates VZV-specific immune responses and may be involved in virus penetration. This study reports the genomic map position and the DNA sequence of a simian varicella virus (SVV) homologue of the VZV gH gene. A 32P-labeled VZV gH-specific DNA probe hybridized to ...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(95)00049-v

    authors： Pumphrey CY,Gray WL

    更新日期：1995-09-01 00:00:00

  • High prevalence of hepatitis E virus in raw sewage in Southern Italy.

    abstract：:Hepatitis E virus (HEV) infections constitute a significant health problem worldwide. The burden of hepatitis E in Italy seems low when compared with other European countries. In recent years, improved surveillance activities in Italy have revealed marked geographical differences in HEV epidemiology, with some regions...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2019.197710

    authors： Di Profio F,Melegari I,Palombieri A,Sarchese V,Arbuatti A,Fruci P,Marsilio F,Martella V,Di Martino B

    更新日期：2019-10-15 00:00:00

  • RNA structure analysis of alphacoronavirus terminal genome regions.

    abstract：:Coronavirus genome replication is mediated by a multi-subunit protein complex that is comprised of more than a dozen virally encoded and several cellular proteins. Interactions of the viral replicase complex with cis-acting RNA elements located in the 5' and 3'-terminal genome regions ensure the specific replication o...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/j.virusres.2014.10.001

    authors： Madhugiri R,Fricke M,Marz M,Ziebuhr J

    更新日期：2014-12-19 00:00:00

  • Biological fitness and natural selection of amantadine resistant variants of avian influenza H5N1 viruses.

    abstract：:Outbreaks caused by the highly pathogenic H5N1 avian influenza virus (A/H5N1) devastated the poultry industry in several countries and posed a significant pandemic threat. In addition to culling of infected poultry and vaccination, amantadine has been applied in poultry in some countries to control the spread of the v...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2016.11.032

    authors： Abdelwhab EM,Veits J,Mettenleiter TC

    更新日期：2017-01-15 00:00:00

  • Regulation of pH by the M2 protein of influenza A viruses.

    abstract：:Inhibition of the function of the M2 protein by amantadine can cause a conformational change in the haemagglutinin (HA) of H7 influenza A viruses and the consequent expression of the low pH form of the glycoprotein on the surface of virus-infected cells. Immunofluorescence studies showed that this conversion occurs sh...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(92)90056-f

    authors： Ciampor F,Thompson CA,Grambas S,Hay AJ

    更新日期：1992-03-01 00:00:00

  • Genetic analysis of hantaviruses carried by reed voles Microtus fortis in China.

    abstract：:To gain more insights into the epidemiology of hantaviruses in China, the hantaviral S, M and L segment sequences were recovered from two Microtus fortis captured in Shenyang and four M. fortis trapped in Yuanjiang in China. Genetic analysis revealed that Shenyang sequences are closely related to the sequences of Fuso...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2008.06.012

    authors： Zou Y,Xiao QY,Dong X,Lv W,Zhang SP,Li MH,Plyusnin A,Zhang YZ

    更新日期：2008-10-01 00:00:00

  • Disruption of the baculovirus core gene ac78 results in decreased production of multiple nucleocapsid-enveloped occlusion-derived virions and the failure of primary infection in vivo.

    abstract：:The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac78 gene is one of the baculovirus core genes. Recent studies showed that ac78 is essential for budded virion (BV) production and the embedding of occlusion-derived virion (ODV) into occlusion body during the AcMNPV life cycle. Here, we report that an ...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2014.07.019

    authors： Li SN,Wang JY,Yuan MJ,Yang K

    更新日期：2014-10-13 00:00:00

  • DNA mediated immunization with encoding the nucleoprotein gene of porcine transmissible gastroenteritis virus.

    abstract：:The immune response to a naked plasmid DNA encoding the nucleoprotein (N protein) of porcine transmissible gastroenteritis virus (TGEV) was investigated in this study. A complementary DNA of the entire N gene was amplified by RT-PCR, and inserted into a mammalian expression vector (pcDNA3.1) to construct a recombinant...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(01)00333-1

    authors： Liu C,Kokuho T,Kubota T,Watanabe S,Inumaru S,Yokomizo Y,Onodera T

    更新日期：2001-11-28 00:00:00

  • Inhibition of Theiler's virus-induced apoptosis in infected murine macrophages results in necroptosis.

    abstract：:In mice Theiler's murine encephalomyelitis virus (TMEV) persists in macrophages that eventually undergo apoptosis. TMEV infection of macrophages in culture induces apoptosis through the intrinsic pathway, restricting virus yields. We show that inhibition of TMEV-induced apoptosis leads to phosphorylation of receptor i...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2014.10.017

    authors： Son KN,Lipton HL

    更新日期：2015-01-02 00:00:00

  • Genetic and phylogenetic analysis of the core proteins VP1, VP3, VP4, VP6 and VP7 of epizootic haemorrhagic disease virus (EHDV).

    abstract：:The core proteins of epizootic haemorrhagic disease virus (EHDV) have important roles to perform in maintaining the structure and function of the virus. A complete genetic and phylogenetic analysis was therefore performed on these proteins (and the genes that code for them) to allow comparison of the selective pressur...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2009.07.011

    authors： Anthony SJ,Maan N,Maan S,Sutton G,Attoui H,Mertens PP

    更新日期：2009-11-01 00:00:00

  • Differential susceptibility of resting CD4(+) T lymphocytes to a T-tropic and a macrophage (M)-tropic human immunodeficiency virus type 1 is associated with their surface expression of CD38 molecules.

    abstract：:Recent evidence has accumulated which definitively shows that chemokine receptors CCR5 and CXCR4 play an essential role as coreceptors for human immunodeficiency virus type 1 (HIV-1) infection. Flow cytometric analysis permitted us to detect CD38, a surface marker of early differentiation, as well as activation of T c...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(00)00220-3

    authors： Horikoshi H,Kinomoto M,Sasao F,Mukai T,Luftig RB,Ikuta K

    更新日期：2001-01-01 00:00:00

  • Elevated antigen-specific Th2 type response is associated with the poor prognosis of hand, foot and mouth disease.

    abstract：:The immunopathogenesis of severe hand, foot and mouth disease (HFMD) remains elusive. This study revealed that enterovirus 71 (EV71) epitope-specific CD4+ T cell responses of HFMD patients were skewed toward a Th2 cytokine profile. Patients that demonstrated higher levels of IL-4 expression in their CD4 T cells follow...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2013.07.009

    authors： Wei R,Xu L,Zhang N,Zhu K,Yang J,Yang C,Deng C,Zhu Z,De Groot AS,Altmeyer R,Zeng M,Leng Q

    更新日期：2013-10-01 00:00:00

  • Molecular characterisation of Atlantic salmon paramyxovirus (ASPV): a novel paramyxovirus associated with proliferative gill inflammation.

    abstract：:Atlantic salmon paramyxovirus (ASPV) was isolated in 1995 from gills of farmed Atlantic salmon suffering from proliferative gill inflammation. The complete genome sequence of ASPV was determined, revealing a genome 16,968 nucleotides in length consisting of six non-overlapping genes coding for the nucleo- (N), phospho...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2008.01.006

    authors： Falk K,Batts WN,Kvellestad A,Kurath G,Wiik-Nielsen J,Winton JR

    更新日期：2008-05-01 00:00:00

  • The avian and mammalian host range of highly pathogenic avian H5N1 influenza.

    abstract：:Highly pathogenic H5N1 influenza viruses have been isolated from a number of avian and mammalian species. Despite intensive control measures the number of human and animal cases continues to increase. A more complete understanding of susceptible species and of contributing environmental and molecular factors is crucia...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/j.virusres.2013.09.004

    authors： Kaplan BS,Webby RJ

    更新日期：2013-12-05 00:00:00

  • Surveillance and diagnostics of the emergent Sri Lankan cassava mosaic virus (Fam. Geminiviridae) in Southeast Asia.

    abstract：:Emergent agricultural pathogens cause severe damage worldwide and their invasive potential is significantly increased by global trade, crop intensification and climate change. Standard surveillance and diagnostic protocols need to be evaluated and implemented, particularly with diseases caused by a wide range of patho...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2020.197959

    authors： Siriwan W,Jimenez J,Hemniam N,Saokham K,Lopez-Alvarez D,Leiva AM,Martinez A,Mwanzia L,Becerra Lopez-Lavalle LA,Cuellar WJ

    更新日期：2020-08-01 00:00:00

  • Murine leukemia virus reverse transcriptase: structural comparison with HIV-1 reverse transcriptase.

    abstract：:Recent X-ray crystal structure determinations of Moloney murine leukemia virus reverse transcriptase (MoMLV RT) have allowed for more accurate structure/function comparisons to HIV-1 RT than were formerly possible. Previous biochemical studies of MoMLV RT in conjunction with knowledge of sequence homologies to HIV-1 R...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/j.virusres.2008.01.001

    authors： Coté ML,Roth MJ

    更新日期：2008-06-01 00:00:00

  • Occurrence, sequence polymorphism and population structure of Circulifer tenellus virus 1 in a field population of the beet leafhopper.

    abstract：:Circulifer tenellus virus 1 (CiTV1) is the prototypical example of an unusual group of dsRNA viruses associated with insects and for which ecological data are lacking. A San Joaquin Valley (SJV), California population of the beet leafhopper (BLH; Circulifer tenellus [Baker]) was sampled for CiTV1 in 2010. Among 365 BL...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2013.06.017

    authors： Spear A,Yokomi R,French R,Stenger DC

    更新日期：2013-09-01 00:00:00

  • Amino acid at position 95 of the matrix protein is a cytopathic determinant of rabies virus.

    abstract：:The molecular mechanism involved in cytopathogenicity of rabies virus has not been fully elucidated yet. A fixed rabies virus Nishigahara strain does not induce clear cytopathic effect (CPE) in mouse neuroblastoma (NA) cells, whereas Ni-CE strain, which was established after 100 passages of Nishigahara strain in chick...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2008.05.011

    authors： Mita T,Shimizu K,Ito N,Yamada K,Ito Y,Sugiyama M,Minamoto N

    更新日期：2008-10-01 00:00:00

  • Differential suppression of host cell protein synthesis and mRNA levels in herpes simplex virus-infected endothelial cells.

    abstract：:Earlier studies from this laboratory have shown that infection of vascular cells with herpes simplex virus 1 or 2 (HSV-1, HSV-2) results in the differential suppression of extracellular matrix proteins including fibronectin (FN), type IV collagen, thrombospondin (TSP) and Factor VIII von Willebrand protein. The presen...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(91)90047-y

    authors： Brinker JM,Ziaie Z,Kefalides NA

    更新日期：1991-05-01 00:00:00

  • The complete sequences of two divergent variants of the rhabdovirus raspberry vein chlorosis virus and the design of improved primers for virus detection.

    abstract：:The complete sequence was obtained for two variants of raspberry vein chlorosis virus (RVCV), confirming that this virus is a rhabdovirus most closely related to the cytorhabdoviruses alfalfa dwarf virus and strawberry crinkle virus. The two RVCV variants share only a 68% nucleotide sequence identity so that the previ...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2019.03.004

    authors： Jones S,McGavin W,MacFarlane S

    更新日期：2019-05-01 00:00:00

  • Tomato spotted wilt virus glycoprotein G(C) is cleaved at acidic pH.

    abstract：:Tomato spotted wilt virus (TSWV) is a plant-infecting member of the family Bunyaviridae. TSWV encodes two envelope glycoproteins, G(N) and G(C), which are required for virus infection of the arthropod vector. Other members of the Bunyaviridae enter host cells by pH-dependent endocytosis. During this process, the glyco...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2005.01.007

    authors： Whitfield AE,Ullman DE,German TL

    更新日期：2005-06-01 00:00:00

  • Induction of insert-specific immune response in mice by hamster polyomavirus VP1 derived virus-like particles carrying LCMV GP33 CTL epitope.

    abstract：:Hamster polyomavirus (HaPyV) major capsid protein VP1 based chimeric virus-like particles (VLPs) carrying model GP33 CTL epitope derived from Lymphocytic choriomeningitis virus (LCMV) were generated in yeast and examined for their capability to induce CTL response in mice. Chimeric VP1-GP33 VLPs were effectively proce...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2011.08.003

    authors： Mazeike E,Gedvilaite A,Blohm U

    更新日期：2012-01-01 00:00:00