Transmission of influenza A/H5N1 viruses in mammals.

Abstract:

:Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of factors that modulate the transmission and replication of influenza A viruses in humans are not yet known, we are beginning to understand some of the molecular changes that may allow H5N1 influenza A viruses to transmit via aerosols or respiratory droplets among mammals. A better understanding of the biological basis and genetic determinants that confer transmissibility to H5N1 influenza A viruses in mammals is important to enhance our pandemic preparedness.

journal_name

Virus Res

journal_title

Virus research

authors

Imai M,Herfst S,Sorrell EM,Schrauwen EJ,Linster M,De Graaf M,Fouchier RA,Kawaoka Y

doi

10.1016/j.virusres.2013.07.017

subject

Has Abstract

pub_date

2013-12-05 00:00:00

pages

15-20

issue

1

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(13)00239-6

journal_volume

178

pub_type

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