Abstract：
:Reovirus is a gastroenteric virus with a genome that consists of ten segments of double-stranded RNA. The segmented nature of the genome allows for genetic mixing when cells are simultaneously infected with two different viral serotypes. The ability of viral reassortment to take place in asynchronous infections has not previously been investigated with mammalian reoviruses. In this study, five different cell lines, representing mouse, monkey, and human, were infected synchronously or asynchronously with various sets of two different temperature-sensitive (ts) reovirus mutants in order to study the genetic interactions which occur. Recombinant viruses were detected at high frequency when infection by the two different ts mutants was separated by as much as 24 h, suggesting that superinfection exclusion does not play a role in reovirus mixed infections. The apparent lack of superinfection exclusion in reovirus infections may have important implications in its evolution.
journal_name
Virus Resjournal_title
Virus researchauthors
Keirstead ND,Coombs KMdoi
10.1016/s0168-1702(98)00023-9subject
Has Abstractpub_date
1998-04-01 00:00:00pages
225-35issue
2eissn
0168-1702issn
1872-7492pii
S0168170298000239journal_volume
54pub_type
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