The actin cytoskeleton is important for rotavirus internalization and RNA genome replication.

abstract：:Five strains of Coxsackie B4 virus and one of Echo 11 virus were tested with regard to their ability to replicate in pancreatic mouse beta-cells and interfere with the alterations of the cytoplasmic Ca2+ concentration ([Ca2+]i) induced by glucose. All strains except one both multiplied and caused cytopathic effect. In...

journal_title：Virus research

authors： Frisk G,Grapengiesser E,Diderholm H

更新日期：1994-09-01 00:00:00

abstract：:The identification of ligand-binding sites is often the first step in drug targeting and design. To date there are numerous computational tools available to predict ligand binding sites. These tools can guide or mitigate the need for experimental methods to identify binding sites, which often require significant resou...

journal_title：Virus research

authors： Brown JA,Espiritu MV,Abraham J,Thorpe IF

更新日期：2016-08-15 00:00:00

abstract：:The effect of mild heat shock on the replication of human cytomegalovirus (HCMV) was studied in human embryo fibroblasts. Treatment of cell cultures at 44 degrees C for 10 min just before infection or at 24 h post infection (p.i.) shortened HCMV eclipse period and enhanced viral replication, while heat shock performed...

journal_title：Virus research

authors： Zerbini M,Musiani M,La Placa M

更新日期：1986-12-01 00:00:00

abstract：:The Foot-and-mouth disease virus (FMDV) causes important economical losses in livestock farming. In order to develop a novel subunit vaccine against FMDV, we constructed recombinant baculoviruses that display the protein VP1 of FMDV on their surface, with either polar (fused to gp64) or nonpolar (fused to anchor membr...

journal_title：Virus research

authors： Peralta A,Maroniche GA,Alfonso V,Molinari P,Taboga O

更新日期：2013-07-01 00:00:00

abstract：:Influenza A (H1N1) virus, a high-risk infectious pathogen, can cause severe acute lung injury leading to significant morbidity and mortality. Angiotensin-converting enzyme 2 (ACE2), a negative regulator of the renin-angiotensin system (RAS), plays a protective role in pathogenesis of acute lung injury. Here, we showed...

journal_title：Virus research

authors： Liu X,Yang N,Tang J,Liu S,Luo D,Duan Q,Wang X

更新日期：2014-06-24 00:00:00

abstract：:The K1L protein of vaccinia virus is required for its growth in certain cell lines (RK-13 and human). The cowpox host-range protein CP77 has been shown to complement K1L function in RK-13 cells, despite a lack of homology between the two proteins except for ankyrin repeats. We investigated the role of ankyrin repeats ...

journal_title：Virus research

authors： Bradley RR,Terajima M

更新日期：2005-12-01 00:00:00

abstract：:In order to understand the factors influencing pathogenicity of a virus, two neutralization escape (NE) variants were selected from wild type lineage 1 West Nile virus (WNV) 68856 strain pathogenic by intra-peritoneal (i.p.) route using monoclonal antibodies (MAbs) against envelope (E) protein. Both NE IF1A7 1.1 and N...

journal_title：Virus research

authors： Sapkal GN,Harini S,Ayachit VM,Fulmali PV,Mahamuni SA,Bondre VP,Gore MM

更新日期：2011-06-01 00:00:00

abstract：:The evolution of virus diseases, both their emergence and disappearance, involves complex interactions between the agent, the host, and the environment. These themes are illustrated by three examples, poliomyelitis of humans, bovine spongiform encephalopathy of cattle, and AIDS of humans. Emergence may be due to evolu...

journal_title：Virus research

authors： Nathanson N,McGann KA,Wilesmith J,Desrosiers RC,Brookmeyer R

更新日期：1993-07-01 00:00:00

abstract：:Prion diseases are fatal neurodegenerative disorders by which the native cellular prion protein (PrPC) is misfolded into an accumulating, disease-associated isoform (PrPD). To improve the understanding of prion pathogenesis and develop effective treatments, it is essential to elucidate factors contributing to cellular...

journal_title：Virus research

authors： Dinkel KD,Schneider DA,Muñoz-Gutiérrez JF,McElliott VR,Stanton JB

更新日期：2017-08-15 00:00:00

abstract：:Mouse Hepatitis Virus (MHV) is a single-stranded positive sense RNA virus with the ability to promote acute and chronic diseases in mice. The MHV spike protein (S) is a major virulence determinant which in addition to binding to cellular receptors to mediate cell entry and facilitate virus spread to adjacent cells by ...

journal_title：Virus research

authors： Kaufman G,Liu P,Leibowitz JL

更新日期：2014-08-30 00:00:00

abstract：:Adult T cell leukemia/lymphoma (ATL) is a highly aggressive CD4+/CD25+ T-cell malignancy caused by human T cell lymphotropic virus type 1 (HTLV-1). Previous studies in the MET-1 cell/NOD/SCID mouse model of ATL demonstrated that MET-1 cells are very susceptible to measles virus (MV) oncolytic therapy. To further evalu...

journal_title：Virus research

authors： M Parrula MC,Fernandez SA,Landes K,Huey D,Lairmore M,Niewiesk S

更新日期：2014-08-30 00:00:00

abstract：:The protein and glycoprotein composition of a sucrose gradient fraction from vaccinia infected cells treated with rifampicin was studied. This particulate fraction contained cytoplasmic membranes and pleomorphic membranous structures. The glycoproteins (89, 42 and 20-23 kDa, respectively) were identified as the same g...

journal_title：Virus research

authors： Payne LG,Kristensson K

更新日期：1990-08-01 00:00:00

abstract：:This study reports the detection by RT-PCR and molecular characterization of partial RdRp gene of picobirnavirus (PBV) dsRNA in fecal samples (n = 100) from a meat sheep flock in southern Brazil. The analysis of the results allowed the identification of two important characteristics of PBV infection. The first was the...

journal_title：Virus research

authors： Kunz AF,Possatti F,de Freitas JA,Alfieri AA,Takiuchi E

更新日期：2018-08-15 00:00:00

abstract：:Fruit trees of temperate and tropical climates are of great economical importance worldwide and several viruses have been reported affecting their productivity and longevity. Fruit trees of different Brazilian regions displaying virus-like symptoms were evaluated for infection by circular DNA viruses. Seventy-four fru...

journal_title：Virus research

authors： Basso MF,da Silva JC,Fajardo TV,Fontes EP,Zerbini FM

更新日期：2015-12-02 00:00:00

abstract：:Several potexviruses (Family Alphaflexiviridae) have been reported infecting cassava (Manihot esculenta Crantz) in the Americas. They were isolated from severely diseased plants during the last 30-40 years and include: Cassava common mosaic virus (CsCMV), Cassava Caribbean mosaic virus (CsCaMV), Cassava Colombian symp...

journal_title：Virus research

authors： Lozano I,Leiva AM,Jimenez J,Fernandez E,Carvajal-Yepes M,Cuervo M,Cuellar WJ

更新日期：2017-09-15 00:00:00

abstract：:St. Louis encephalitis virus (SLEV), a flavivirus transmitted to humans by Culex mosquitoes, causes clinical symptoms ranging from acute febrile disorder to encephalitis. To reach the central nervous system (CNS) from circulating blood, the pathogen must cross the blood-brain barrier formed by endothelial cells and as...

journal_title：Virus research

authors： Zuza AL,Barros HL,de Mattos Silva Oliveira TF,Chávez-Pavoni JH,Zanon RG

更新日期：2016-06-02 00:00:00

abstract：:To examine the regulatory properties of feline immunodeficiency virus (FIV) long terminal repeat (LTR) integrated into host chromatin, Crandell feline kidney cells were stably transfected with the FIV LTR that directs the bacterial chloramphenicol acetyltransferase (CAT) gene. Using these cells, we examined the effect...

journal_title：Virus research

authors： Ikeda Y,Kawaguchi Y,Tomonaga K,Inoshima Y,Kohmoto M,Miyazawa T,Mikami T

更新日期：1996-04-01 00:00:00

abstract：:In this study we demonstrated that Macrobrachium rosenbergii nodavirus (MrNV) was able to internalize and replicate in Sf9 insect cells, with levels of infection altered by substances affecting the caveolin-(CAV) mediated endocytosis pathway. The use of Sf9 cells for efficient MrNV replication and propagation was demo...

journal_title：Virus research

authors： Somrit M,Watthammawut A,Chotwiwatthanakun C,Weerachatyanukul W

更新日期：2016-09-02 00:00:00

abstract：:Cell lines were constructed which permanently express influenza virus-specific RNA. Two approaches were followed. C127 cells were transformed with bovine papilloma virus (BPV) vectors and the resulting cell lines were found to inhibit the replication of influenza virus at low multiplicity of infection (MOI 0.05). Howe...

journal_title：Virus research

authors： Leiter JM,Krystal M,Palese P

更新日期：1989-10-01 00:00:00

abstract：:The spread of H5N1 virus into a wide range of avian and mammalian species may facilitate the adaptation of the virus to human populations. In the present study, a survey of avian influenza virus in tree sparrows was performed and a HPAI H5N1 virus (A/tree sparrow/Jiangsu/1/08) was isolated. The H5N1 virus was found to...

journal_title：Virus research

authors： Liu Q,Ma J,Kou Z,Pu J,Lei F,Li T,Liu J

更新日期：2010-01-01 00:00:00

abstract：:Poliovirus (PV) infects susceptible cells through poliovirus receptor (PVR), which functions to bind virus and to convert its conformation. To study early infection process of PV, infection systems were employed using in vitro cultured cells and in vivo neural pathway of PVR transgenic (Tg) mice. For in vitro study, m...

journal_title：Virus research

authors： Arita M,Ohka S,Sasaki Y,Nomoto A

更新日期：1999-08-01 00:00:00

abstract：:The release of retrovirus particles from the infected cell is greatly stimulated by short motifs, known as "late" or "L" domains, present within the Gag precursor protein. Three distinct classes of L domains have been identified; these bear the core sequence: Pro-Thr/Ser-Ala-Pro [P(T/S)AP], Pro-Pro-x-Tyr (PPxY), or Ty...

journal_title：Virus research

authors： Demirov DG,Freed EO

更新日期：2004-12-01 00:00:00

abstract：:Studies on the Marek's disease virus (MDV) serotype 2 (MDV2) genome may be important for understanding the naturally nononcogenic nature of the virus. To determine the complete DNA sequence of MDV2 unique short (Us) region, genomic BamHI fragments F, M1 and R were sequenced. The MDV2 Us region is 12109 bp long and con...

journal_title：Virus research

authors： Jang HK,Ono M,Kim TJ,Izumiya Y,Damiani AM,Matsumura T,Niikura M,Kai C,Mikami T

更新日期：1998-11-01 00:00:00

abstract：:Herein we describe the construction of recombinant human rhinoviruses (rHRVs) encoding HIV Gag or Tat by inserting the full length tat gene or regions of the gag gene flanked by sequences encoding the HRV 2A protease cleavage site into the junction between HRV genes encoding structural (P1) and non-structural (P2) pro...

journal_title：Virus research

authors： Tomusange K,Yu W,Suhrbier A,Wijesundara D,Grubor-Bauk B,Gowans EJ

更新日期：2015-05-04 00:00:00

abstract：:Genomoviruses are circular single-stranded DNA viruses (∼2 kb in size) classified into nine genera, they are highly diverse and have been identified in a variety of samples ranging from fungi to animal sera. Here we identify five genomoviruses belonging to the Gemycircularvirus genus and one to the Gemykibivirus genus...

journal_title：Virus research

authors： Kraberger S,Hofstetter RW,Potter KA,Farkas K,Varsani A

更新日期：2018-09-02 00:00:00

abstract：:Hepatitis A virus (HAV) is an important human pathogen causing hepatitis, with high incidence in developed as well as in developing countries. No vaccines are available. In order to determine the primary structure of the HAV genome, we have prepared cDNAs from viral RNA and cloned these into plasmid pBR322. These clon...

journal_title：Virus research

authors： Paul AV,Tada H,von der Helm K,Wissel T,Kiehn R,Wimmer E,Deinhardt F

更新日期：1987-08-01 00:00:00

abstract：:Raccoons (Procyon lotor), which are not native to Japan, have been suspected to transmit various pathogens by frequent intrusion into agricultural and residential areas. To determine influenza A virus seropositivity in raccoons in Japan, we examined a total of 634 raccoons captured in 19 towns (A-S) from 2009 to 2012....

journal_title：Virus research

authors： Yamaguchi E,Sashika M,Fujii K,Kobayashi K,Bui VN,Ogawa H,Imai K

更新日期：2014-08-30 00:00:00

abstract：:The encephalomyocarditis (EMC) virus-induced diabetes-like syndrome in mouse inbred strains was used as a model to study the insulin-dependent diabetes mellitus (IDDM). Our investigations were performed with two EMC virus variants, PV2 and PV7. After infection of SJL mice with 10(5) PFU of PV2 about 70% of the animals...

journal_title：Virus research

authors： Nelsen-Salz B,Zimmermann A,Wickert S,Arnold G,Botta A,Eggers HJ,Kruppenbacher JP

更新日期：1996-04-01 00:00:00

abstract：:JCPyV and BKPyV are common human polyomaviruses that cause lifelong asymptomatic persistent infections in their hosts. In immunosuppressed individuals, increased replication of JCPyV and BKPyV cause significant disease. JCPyV causes a fatal and rapidly progressing demyelinating disease known as progressive multifocal ...

journal_title：Virus research

authors： O'Hara BA,Rupasinghe C,Yatawara A,Gaidos G,Mierke DF,Atwood WJ

更新日期：2014-08-30 00:00:00

abstract：:Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus containing positive strand RNA as a genome. Recently, the three-dimensional structures of the HEV-like particles and spike domain protruded from the surface of the pa...

journal_title：Virus research

authors： Mori Y,Matsuura Y

更新日期：2011-10-01 00:00:00