Abstract：
:During 2017, a G4P[6] group A rotavirus strain was identified in the feces of an Italian child hospitalized for acute gastroenteritis in Southern Italy. Nucleotide sequencing of the 11 genomic segments, revealed the G4-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1 genotype constellation. Phylogenetic analyses of the gene segments investigated revealed high nucleotide sequence identities with G4P[6] RVA strains detected previously in pigs and in humans. The human strains related to the Italian G4P[6] were mainly reported from Asia, and were detected after an inter-species transmission event from swine. This study reports the genotyping and phylogenetic analysis of a G4P[6] RVA strain presenting a genomic constellation never detected before in Italy. In addition, this strain was able to cause AGE symptoms in a healthy child, successively hospitalized. The molecular characterization suggested zoonotic origin and inter-species transmission of this strain from swine, living open the possibility of its importation from abroad.
journal_name
Virus Resjournal_title
Virus researchauthors
Ianiro G,Micolano R,Conte M,Labianca M,Vaccari G,Monini Mdoi
10.1016/j.virusres.2018.11.003subject
Has Abstractpub_date
2019-01-15 00:00:00pages
7-11eissn
0168-1702issn
1872-7492pii
S0168-1702(18)30566-5journal_volume
260pub_type
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