Abstract：
:We have determined the post-translational modifications of the major capsid protein, L1 of human papillomavirus (HPV) type 6b. Since this virus cannot be cultured in the laboratory to obtain sufficient material for a study, a recombinant L1 protein produced in a vaccinia virus expression system was used in this investigation. Our results show that this protein is phosphorylated at serine residues and is also glycosylated. No myristoylation or palmitoylation was detected. The fraction of L1 protein incorporated into virus-like particles was not glycosylated. Since recombinant L1 protein is a potential human vaccine candidate, knowledge of the post-translation modifications of this protein may prove useful for the design of anti-HPV vaccines.
journal_name
Virus Resjournal_title
Virus researchauthors
Fang NX,Frazer IH,Zhou J,Fernando GJdoi
10.1016/s0168-1702(98)00117-8subject
Has Abstractpub_date
1999-04-01 00:00:00pages
113-21issue
2eissn
0168-1702issn
1872-7492pii
S0168170298001178journal_volume
60pub_type
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