Abstract：
:Persisting DNA of parvovirus H-1 could be demonstrated in cells of two human lymphoma cell lines, the Burkitt lymphoma cell line BL2 and the T-cell leukemia cell line Jurkat which survived infection with parvovirus H-1. Persistence of H-1 DNA rendered the cells resistant to a second H-1 infection. This resistance to H-1 superinfection persisted even after loss of H-1 DNA occurring after approximately 150-200 cell generations. Resistance to H-1 superinfection was accompanied by reduced uptake of infectious particles and by a block of H-1 DNA replication. This suggests that persistent H-1 infection leads to modifications of cellular functions involved in the permissivity for H-1.
journal_name
Virus Resjournal_title
Virus researchauthors
Faisst S,Bartnitzke S,Schlehofer JR,zur Hausen Hdoi
10.1016/0168-1702(90)90024-6subject
Has Abstractpub_date
1990-06-01 00:00:00pages
211-23issue
2eissn
0168-1702issn
1872-7492pii
0168-1702(90)90024-6journal_volume
16pub_type
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