abstract：:Cathelicidin antimicrobial peptides (human LL-37 and mouse CRAMP) are mainly virucidal to enveloped virus. However, the effects and relative mechanisms of LL-37 and CRAMP on non-enveloped virus are elusive. We herein found that CRAMP expression was significantly up-regulated post non-enveloped Enterovirus 71 (EV71) in...

journal_title：Antiviral research

authors： Yu J,Dai Y,Fu Y,Wang K,Yang Y,Li M,Xu W,Wei L

更新日期：2021-01-25 00:00:00

abstract：:Since 2011, highly pathogenic pseudorabies virus (PRV) variants that emerged on many farms in China have posed major economic burdens to the animal industry and have even recently caused several human cases of viral encephalitis. Currently, there are no approved effective drugs to treat PRV associated diseases in huma...

journal_title：Antiviral research

authors： Wang G,Chen R,Huang P,Hong J,Cao J,Wu Q,Zheng W,Lin L,Han Q,Chen Y,Xia N

更新日期：2021-01-07 00:00:00

abstract：:Vaccines and antiviral agents are in urgent need to stop the COVID-19 pandemic. To facilitate antiviral screening against SARS-CoV-2 without requirement for high biosafety level facility, we developed a bacterial artificial chromosome (BAC)-vectored replicon of SARS-CoV-2, nCoV-SH01 strain, in which secreted Gaussia l...

journal_title：Antiviral research

authors： Zhang Y,Song W,Chen S,Yuan Z,Yi Z

更新日期：2021-01-01 00:00:00

abstract：:Middle East Respiratory Syndrome (MERS) is a respiratory disease caused by a coronavirus (MERS-CoV). Since its emergence in 2012, nosocomial amplifications have led to its high epidemic potential and mortality rate of 34.5%. To date, there is an unmet need for vaccines and specific therapeutics for this disease. Avail...

journal_title：Antiviral research

authors： Gan HJ,Harikishore A,Lee J,Jeon S,Rajan S,Chen MW,Neo JL,Kim S,Yoon HS

更新日期：2021-01-01 00:00:00

abstract：:Prevention of HIV infection and unintended pregnancies are public health priorities. In sub-Saharan Africa, where HIV prevalence is highest, depot medroxyprogesterone acetate (DMPA) is widely used as contraception. Therefore, understanding potential interactions between DMPA and antiretrovirals is critical. Here, we u...

journal_title：Antiviral research

authors： Daly MB,Sterling M,Holder A,Dinh C,Nishiura K,Khalil G,García-Lerma JG,Dobard C

更新日期：2020-12-29 00:00:00

abstract：:Dengue virus (DENV) infection is one of the most important infectious diseases in tropical and subtropical regions around the world. Previously, we performed an initial phenotypic screening of 7000 compounds using DENV type 2 (DENV2)-infected BHK-21 cells to identify small molecules which could inhibit virus replicati...

journal_title：Antiviral research

authors： Nobori H,Uemura K,Toba S,Sanaki T,Shishido T,Hall WW,Orba Y,Sawa H,Sato A

更新日期：2020-12-01 00:00:00

abstract：:Due to diverse pathogenic potentials, there is a growing need for anti-HCMV agents. In this study, we show that treatment with DAPT, a γ-secretase inhibitor (GSI), impairs HCMV replication as assessed by a progeny assay based on immunostaining. This effect is not limited to DAPT because other GSIs with different struc...

journal_title：Antiviral research

authors： Lee SM,Han D,Kwon M,Noh H,Lee JH,Yoon Y,Cho JY,Ahn JH,Yoon K

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Herpes zoster (HZ) risk is high in renal transplant recipients. Vaccination prior to transplantation may provide a useful strategy for the prevention of HZ in the posttranplantation period. However, it is not known whether immunity to varicella-zoster virus (VZV) is affected due to treatment surrounding tran...

journal_title：Antiviral research

authors： Rondaan C,de Joode AAE,Wang L,Siderius M,Raveling-Eelsing E,van Leer-Buter C,van Assen S,Bos NA,Westra J

更新日期：2020-11-01 00:00:00

abstract：:Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded R...

journal_title：Antiviral research

authors： Prasanth KR,Hirano M,Fagg WS,McAnarney ET,Shan C,Xie X,Hage A,Pietzsch CA,Bukreyev A,Rajsbaum R,Shi PY,Bedford MT,Bradrick SS,Menachery V,Garcia-Blanco MA

更新日期：2020-10-01 00:00:00

abstract：:There is a pressing need for new vaccines against alphaviruses, which can cause fatal encephalitis (Venezuelan equine encephalitis virus (VEEV) and others) and severe arthralgia (e.g. Chikungunya virus, CHIKV). These positive-strand RNA viruses are diverse and evolve rapidly, meaning that the sequence of any vaccine s...

journal_title：Antiviral research

authors： Baker WS,Negi S,Braun W,Schein CH

更新日期：2020-10-01 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) infection is known to cause skin blisters, keratitis as well as deadly cases of encephalitis in some situations. Only a few therapeutic modalities are available for this globally prevalent infection. Very recently, a small molecule BX795 was identified as an inhibitor of HSV-1 protein sy...

journal_title：Antiviral research

authors： Iqbal A,Suryawanshi R,Yadavalli T,Volety I,Shukla D

更新日期：2020-08-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. In immunocompromised patients, KSHV infection is capable of causing severe and fatal diseases. Current antiviral treatments for KSHV infections consist mostly of n...

journal_title：Antiviral research

authors： Chen J,Zhang H,Chen X

更新日期：2020-08-01 00:00:00

abstract：:Foot-and-mouth disease is a viral illness that affects cloven-hoofed animals causing serious economic losses. Inactivated vaccines against its causative agent, foot-and-mouth disease virus (FMDV), require approximately seven days to induce protection. Therefore, antiviral strategies are needed to provide earlier prote...

journal_title：Antiviral research

authors： Molina GN,Cacciabue M,Gismondi MI,Taboga O,Molinari P

更新日期：2020-08-01 00:00:00

abstract：:Seasonal influenza causes significant morbidity and mortality in people aged ≥65 years. Antiviral treatment can reduce complications and disease severity. The objective of this study was to investigate the effect of antiviral treatment in patients aged ≥65 years hospitalized with confirmed influenza in preventing inte...

journal_title：Antiviral research

authors： Soldevila N,Toledo D,Ortiz de Lejarazu R,Tamames S,Castilla J,Astray J,Fernández MA,Martín V,Egurrola M,Morales Suárez-Varela M,Domínguez À,Working Group of Project PI12\/02079.

更新日期：2020-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a leading cause of chronic hepatitis and end-stage liver diseases. Mature HCV virions are bound by host-derived lipoproteins. Lack of an HCV vaccine warrants a major role of antiviral treatment in the global elimination of hepatitis C. Although direct-acting antivirals (DAAs) are replacing t...

journal_title：Antiviral research

authors： Li X,Li J,Feng Y,Cai H,Li YP,Peng T

更新日期：2020-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a major cause of chronic liver diseases such as steatosis, cirrhosis, and hepatocellular carcinoma. HCV particles have been found to associate with apolipoproteins, and apolipoproteins not only participate in the HCV life cycle, but also help HCV escape recognition by the host immu...

journal_title：Antiviral research

authors： Cai H,Yao W,Huang J,Xiao J,Chen W,Hu L,Mai R,Liang M,Chen D,Jiang N,Zhou L,Peng T

更新日期：2020-05-01 00:00:00

abstract：:Acute lower respiratory tract infections (ALRI) caused by respiratory syncytial virus (RSV) are associated with a severe disease burden among infants and elderly patients. Treatment options are limited. While numerous drug candidates with different viral targets are under development, the utility of RSV entry inhibito...

journal_title：Antiviral research

authors： Blockus S,Sake SM,Wetzke M,Grethe C,Graalmann T,Pils M,Le Goffic R,Galloux M,Prochnow H,Rox K,Hüttel S,Rupcic Z,Wiegmann B,Dijkman R,Rameix-Welti MA,Eléouët JF,Duprex WP,Thiel V,Hansen G,Brönstrup M,Haid S,Piets

更新日期：2020-05-01 00:00:00

abstract：:In spite of a decrease in the prevalence and incidence seen in recent years, chronic hepatitis B (CHB) still remains a major healthcare challenge, prevalent mostly in developing but also in developed regions. CHB is associated with significant morbidity and mortality, secondary to the complications of disease progress...

journal_title：Antiviral research

authors： Koffas A,Petersen J,Kennedy PT

更新日期：2020-05-01 00:00:00

abstract：:Flaviviruses constitute a public health concern because of their global burden and the lack of specific antiviral treatment. Here we investigated the antiviral activity of the alkaloid anisomycin against dengue (DENV) and Zika (ZIKV) viruses. At non-cytotoxic concentrations, anisomycin strongly inhibited the replicati...

journal_title：Antiviral research

authors： Quintana VM,Selisko B,Brunetti JE,Eydoux C,Guillemot JC,Canard B,Damonte EB,Julander JG,Castilla V

更新日期：2020-04-01 00:00:00

abstract：:Enterovirus D68 (EV-D68) is a member of the Picornavirus family and a causative agent of respiratory diseases in children. The incidence of EV-D68 infection has increased worldwide in recent years. Thus far, there are no approved antiviral agents or vaccines for EV-D68. Here, we show that methyl-β-cyclodextrin (MβCD),...

journal_title：Antiviral research

authors： Jiang Y,Liu S,Shen S,Guo H,Huang H,Wei W

更新日期：2020-04-01 00:00:00

abstract：:The global analysis of neuraminidase inhibitor (NAI) susceptibility of influenza viruses has been conducted since the 2012-13 period. In 2018 a novel cap-dependent endonuclease inhibitor, baloxavir, that targets polymerase acidic subunit (PA) was approved for the treatment of influenza virus infection in Japan and the...

journal_title：Antiviral research

authors： Takashita E,Daniels RS,Fujisaki S,Gregory V,Gubareva LV,Huang W,Hurt AC,Lackenby A,Nguyen HT,Pereyaslov D,Roe M,Samaan M,Subbarao K,Tse H,Wang D,Yen HL,Zhang W,Meijer A

更新日期：2020-03-01 00:00:00

abstract：:Wedelolactone (WDL) is a coumestan present in the plants Eclipta prostrata and Wedelia calendulacea which are used for treatment of a multitude of health problems in traditional medicine. It has previously been shown that WDL exerts antiviral activity against human immunodeficiency virus and hepatitis C virus. In this...

journal_title：Antiviral research

authors： Svrlanska A,Ruhland A,Marschall M,Reuter N,Stamminger T

更新日期：2020-02-01 00:00:00

abstract：:The essential role of SMAR1 in HIV-1 transcription and LTR driven gene expression suggests SMAR1 as an HIV dependency factor (HDF) and a potential anti-HIV therapeutic target. Here, we report for the first time, anti-HIV activity of 8 novel isothiocyanate (ITC) derivatives that differentially stabilise SMAR1. Out of 8...

journal_title：Antiviral research

authors： Trivedi J,Alam A,Joshi S,Kumar TP,Chippala V,Mainkar PS,Chandrasekhar S,Chattopadhyay S,Mitra D

更新日期：2020-01-01 00:00:00

abstract：:IRES-driven translation plays an essential role in picornavirus infection. However, there are seldom reports of compounds targeting this pathway with effective protection in animal models. Here, we identified emetine, an antiprotozoal drug, which inhibits EV-A71 with an EC50 value of 0.04 μM and a CC50 value of 10 μM ...

journal_title：Antiviral research

authors： Tang Q,Li S,Du L,Chen S,Gao J,Cai Y,Xu Z,Zhao Z,Lan K,Wu S

更新日期：2020-01-01 00:00:00

abstract：:Both classical swine fever (CSF) and pseudorabies are highly contagious, economically significant diseases of swine in China. Although vaccination with the C-strain against classical swine fever virus (CSFV) is widely carried out and severe outbreaks of CSF seldom occur in China, CSF is sporadic in many pig herds and ...

journal_title：Antiviral research

authors： Tong W,Zheng H,Li GX,Gao F,Shan TL,Zhou YJ,Yu H,Jiang YF,Yu LX,Li LW,Kong N,Tong GZ,Li JC

更新日期：2020-01-01 00:00:00

abstract：:The mammarenavirus Lassa (LASV) is highly prevalent in West Africa where it infects several hundred thousand individuals annually resulting in a high number of Lassa fever (LF) cases, a febrile disease associated with high morbidity and significant mortality. Mounting evidence indicates that the worldwide-distributed ...

journal_title：Antiviral research

authors： Cubitt B,Ortiz-Riano E,Cheng BY,Kim YJ,Yeh CD,Chen CZ,Southall NOE,Zheng W,Martinez-Sobrido L,de la Torre JC

更新日期：2020-01-01 00:00:00

abstract：:The influenza A virus (IAV) NS1 protein is one of the major regulators of pathogenicity, being able to suppress innate immune response and host protein synthesis. In this study we identified the human micro RNA hsa-miR-1307-3p as a novel potent suppressor of NS1 expression and influenza virus replication. Transcriptom...

journal_title：Antiviral research

authors： Bavagnoli L,Campanini G,Forte M,Ceccotti G,Percivalle E,Bione S,Lisa A,Baldanti F,Maga G

更新日期：2019-11-01 00:00:00

abstract：:Ribonucleases H (RNases H) are endonucleolytic enzymes, evolutionarily related to retroviral integrases, DNA transposases, resolvases and numerous nucleases. RNases H cleave RNA in RNA/DNA hybrids and their activity plays an important role in the replication of prokaryotic and eukaryotic genomes, as well as in the rep...

journal_title：Antiviral research

authors： Tramontano E,Corona A,Menéndez-Arias L

更新日期：2019-11-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection remains a global health problem, causing nearly one million deaths annually. Forkhead box O (FoxO) transcription factors play important roles in modulating diverse physiological processes. Recent studies show that FoxOs are involved in antiviral responses. In present investigation, we...

journal_title：Antiviral research

authors： Li L,Li Y,Xiong Z,Shu W,Yang Y,Guo Z,Gao B

更新日期：2019-10-01 00:00:00

abstract：:Viral hemorrhagic fevers (VHFs) cause thousands of fatalities every year, but the treatment options for their management remain very limited. In particular, the development of therapeutic interventions is restricted by the lack of commercial viability of drugs targeting individual VHF agents. This makes approaches lik...

journal_title：Antiviral research

authors： Wendt L,Bostedt L,Hoenen T,Groseth A

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:We sought to investigate the differences in monocyte immune responses to the dengue virus (DENV) in those who previously had either severe disease (past SD) or non-severe dengue (past NSD) following a secondary dengue infection. METHOD:Monocytes from healthy individuals who had either past SD (n = 6) or past...

journal_title：Antiviral research

authors： Kamaladasa A,Gomes L,Wijesinghe A,Jeewandara C,Toh YX,Jayathilaka D,Ogg GS,Fink K,Malavige GN

更新日期：2019-09-01 00:00:00

abstract：:The latent reservoir of HIV-1 in resting memory CD4+ T cells serves as a major barrier to curing HIV-1 infection. Reactivation of latent HIV-1 is proposed as a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current latency reversal agents (LRAs), identification of new LRAs ...

journal_title：Antiviral research

authors： Yang H,Li X,Yang X,Lu P,Wang Y,Jiang Z,Pan H,Zhao L,Zhu Y,Khan IU,Shen Y,Lu H,Zhang T,Jiang G,Ma Z,Wu H,Zhu H

更新日期：2019-09-01 00:00:00

abstract：:Several mammarenaviruses, chiefly Lassa virus (LASV) in Western Africa and Junín virus (JUNV) in the Argentine Pampas, cause severe disease in humans and pose important public health problems in their endemic regions. Moreover, mounting evidence indicates that the worldwide-distributed mammarenavirus lymphocytic chori...

journal_title：Antiviral research

authors： Kim YJ,Cubitt B,Chen E,Hull MV,Chatterjee AK,Cai Y,Kuhn JH,de la Torre JC

更新日期：2019-09-01 00:00:00

abstract：:Efavirenz (EFV), a first generation non-nucleoside analogue reverse transcriptase inhibitor widely employed in combination antiretroviral therapy regimens over the last 20 years, has been associated with a wide range of neuropsychiatric effects and has also been linked with HIV-associated neurocognitive disorder (HAND...

journal_title：Antiviral research

authors： Martinez-Arroyo O,Gruevska A,Victor VM,González-Polo RA,Yakhine-Diop SMS,Fuentes JM,Esplugues JV,Blas-Garcia A,Apostolova N

更新日期：2019-08-01 00:00:00

abstract：:Studying the biogenesis of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and developing anti-HBV agents require analytical methods to quantify viral DNA levels inside host cells. The well-accepted Southern blotting method is only semi-quantitative, while the other widely used methods (based on qPCR) ...

journal_title：Antiviral research

authors： Gao Z,Yan L,Li W

更新日期：2019-08-01 00:00:00

abstract：:Cytomegalovirus (CMV) is one of the most common opportunistic infections after transplantation. To prevent CMV infections, universal prophylaxis and pre-emptive therapy with ganciclovir or its prodrug valganciclovir is applied. However, prolonged antiviral therapy may result in drug-resistance emergence. We describe a...

journal_title：Antiviral research

authors： Andrei G,Van Loon E,Lerut E,Victoor J,Meijers B,Bammens B,Sprangers B,Gillemot S,Fiten P,Opdenakker G,Lagrou K,Kuypers D,Snoeck R,Naesens M

更新日期：2019-08-01 00:00:00

abstract：:We have previously reported a new class of dendrimers with tryptophan (Trp) residues on the surface that show dual antiviral activities against HIV and enterovirus EV71. The prototype compound of this family is a derivative of pentaerythritol with 12 peripheral Trp groups and trivalent spacer arms. Here a novel series...

journal_title：Antiviral research

authors： Martínez-Gualda B,Sun L,Martí-Marí O,Mirabelli C,Delang L,Neyts J,Schols D,Camarasa MJ,San-Félix A

更新日期：2019-08-01 00:00:00

abstract：:We report the design, synthesis, and biological evaluation of a class of 1H-pyrido[2,1-b][1,3]benzothiazol-1-ones originated from compound 1, previously identified as anti-flavivirus agent. Some of the new compounds showed activity in low μM range with reasonable selectivity against Dengue 2, Yellow fever (Bolivia str...

journal_title：Antiviral research

authors： Cannalire R,Tarantino D,Piorkowski G,Carletti T,Massari S,Felicetti T,Barreca ML,Sabatini S,Tabarrini O,Marcello A,Milani M,Cecchetti V,Mastrangelo E,Manfroni G,Querat G

更新日期：2019-07-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection causes significant disease in the lower respiratory tract of young children, and there is currently no licensed vaccine to prevent RSV infection. The F glycoprotein is considered a major antigenic target for RSV vaccine development. Recent evidence indicates that the pre-fus...

journal_title：Antiviral research

authors： Zhang Y,Zhou Z,Zhu SL,Zu X,Wang Z,Zhang LK,Wang W,Xiao G

更新日期：2019-05-01 00:00:00

abstract：:Influenza viruses are major respiratory pathogens responsible for both seasonal epidemics and occasional pandemics worldwide. The current available treatment options have limited efficacy and thus the development of new antivirals is highly needed. We previously reported the identification of a series of cycloheptathi...

journal_title：Antiviral research

authors： Nannetti G,Massari S,Mercorelli B,Bertagnin C,Desantis J,Palù G,Tabarrini O,Loregian A

更新日期：2019-05-01 00:00:00