Abstract：
BACKGROUND:Herpes zoster (HZ) risk is high in renal transplant recipients. Vaccination prior to transplantation may provide a useful strategy for the prevention of HZ in the posttranplantation period. However, it is not known whether immunity to varicella-zoster virus (VZV) is affected due to treatment surrounding transplantation. METHODS:Both humoral and cellular immunity to VZV were determined prior to and 2-3 years after renal transplantation in 60 adult patients, and 62 matched healthy controls. VZV-specific cellular immunity was measured by an interferon gamma (IFNγ) enzyme-linked immunospot (ELISpot) assay and by analyzing T-cell functionality using flowcytometry. VZV-IgG levels were measured using an in-house glycoprotein enzyme-linked immunosorbent assay (gpELISA). RESULTS:Using paired analysis, it was determined that numbers of IFNγ-producing cells did not change after transplantation, but were significantly lower in transplant recipients after transplantation than in controls (p = 0.028). Patients in whom the post-transplant period was complicated by rejection or any acute infection (excluding HZ) had a lower number of IFNγ-producing cells than patients who did not. VZV IgG levels did not differ from controls, but a significant decrease was observed after transplantation (p < 0.0001). CONCLUSIONS:VZV-specific cellular immunity, which is essential in the prevention of HZ, did not markedly change in patients following renal transplantation. This suggests that preventive vaccination before transplantation may be beneficial. Our results extend knowledge on VZV immunity after transplantation, vital when considering strategies for the prevention of HZ in these patients.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Rondaan C,de Joode AAE,Wang L,Siderius M,Raveling-Eelsing E,van Leer-Buter C,van Assen S,Bos NA,Westra Jdoi
10.1016/j.antiviral.2020.104938subject
Has Abstractpub_date
2020-11-01 00:00:00pages
104938eissn
0166-3542issn
1872-9096pii
S0166-3542(20)30352-1journal_volume
183pub_type
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journal_title：Antiviral research
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2014.01.020
更新日期：2014-04-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：1994-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0166-3542(94)00067-i
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2008.03.001
更新日期：2008-08-01 00:00:00
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更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：1995-01-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2004.05.005
更新日期：2004-10-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章,评审
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更新日期：2015-09-01 00:00:00
