Abstract:
:Middle East Respiratory Syndrome (MERS) is a respiratory disease caused by a coronavirus (MERS-CoV). Since its emergence in 2012, nosocomial amplifications have led to its high epidemic potential and mortality rate of 34.5%. To date, there is an unmet need for vaccines and specific therapeutics for this disease. Available treatments are either supportive medications in use for other diseases or those lacking specificity requiring higher doses. The viral infection mode is initiated by the attachment of the viral spike glycoprotein to the human Dipeptidyl Peptidase IV (DPP4). Our attempts to screen antivirals against MERS led us to identify montelukast sodium hydrate (MSH), an FDA-approved anti-asthma drug, as an agent attenuating MERS-CoV infection. We showed that MSH directly binds to MERS-CoV-Receptor-Binding Domain (RBD) and inhibits its molecular interaction with DPP4 in a dose-dependent manner. Our cell-based inhibition assays using MERS pseudovirions demonstrated that viral infection was significantly inhibited by MSH and was further validated using infectious MERS-CoV culture. Thus, we propose MSH as a potential candidate for therapeutic developments against MERS-CoV infections.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Gan HJ,Harikishore A,Lee J,Jeon S,Rajan S,Chen MW,Neo JL,Kim S,Yoon HSdoi
10.1016/j.antiviral.2020.104996subject
Has Abstractpub_date
2021-01-01 00:00:00pages
104996eissn
0166-3542issn
1872-9096pii
S0166-3542(20)30410-1journal_volume
185pub_type
杂志文章abstract::Hepatitis B virus (HBV) infection remains a global health problem, causing nearly one million deaths annually. Forkhead box O (FoxO) transcription factors play important roles in modulating diverse physiological processes. Recent studies show that FoxOs are involved in antiviral responses. In present investigation, we...
journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
abstract::Tiazofurine (2-beta-D-ribofuranosylthiazole-4-carboxamide) was found to inhibit replication of barley stripe mosaic virus (BSMV) in barley and wheat plants. Treatment with this nucleoside analogue delayed and inhibited symptom development and suppressed virus multiplication. The most effective concentration applied tw...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(89)90019-3
更新日期:1989-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(84)90032-9
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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更新日期:2018-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(92)90048-a
更新日期:1992-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(98)00051-5
更新日期:1998-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2020.104905
更新日期:2020-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:1981-11-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.07.017
更新日期:2011-11-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(95)00012-b
更新日期:1995-06-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(95)00047-p
更新日期:1995-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2009.12.010
更新日期:2010-03-01 00:00:00
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journal_title:Antiviral research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(84)90006-8
更新日期:1984-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(90)90005-r
更新日期:1990-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2007.11.007
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2002-06-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2003.10.004
更新日期:2004-03-01 00:00:00
abstract::Favipiravir (T-705) is a new anti-influenza drug approved for human use in Japan and progressing through Phase 3 clinical trials in the U.S. In addition to its potent inhibitory effects against influenza virus infection, the compound has been shown to be broadly active against RNA viruses from 9 different families, in...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2015.07.003
更新日期:2015-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(88)90004-6
更新日期:1988-04-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.08.016
更新日期:2011-11-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2018.01.003
更新日期:2018-03-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2012.05.017
更新日期:2012-09-01 00:00:00
abstract::The 27th International Conference on Antiviral Research (ICAR) was held in Raleigh, North Carolina, USA from May 12 to 16, 2014. This article summarizes the principal invited lectures. John Drach (Elion Award) described the early days of antiviral drugs and their novel modes of action. Piet Herdewijn (Holý Award) used...
journal_title:Antiviral research
pub_type:
doi:10.1016/j.antiviral.2014.08.009
更新日期:2014-11-01 00:00:00
abstract::The heterocycle, 4,6-dibenzamidopyrazolo[3,4-d]pyrimidine (DBAPP), inhibited cytopathology induced by human, mouse, and vervet monkey cytomegaloviruses (CMV) in vitro at 0.2 to 0.5 microM, but did not inhibit cell replication at less than or equal to 30 microM. Herpes simplex viruses were unaffected by the inhibitor. ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(90)90040-e
更新日期:1990-01-01 00:00:00
abstract::Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors that are widely used for the treatment of hypercholesterolemia. Besides their cholesterol-lowering effect, statins have been reported to have antiviral activity against a variety of viruses, including hepatitis C virus (HCV). Several stat...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2014.02.020
更新日期:2014-05-01 00:00:00