Dual effects of the novel ingenol derivatives on the acute and latent HIV-1 infections.

abstract：:Citrusinine-I, a new acridone alkaloid isolated from the root bark of the citrus plant (Rutaceae), exhibited potent activity against herpes simplex virus (HSV) type 1 and type 2 at low concentrations relative to their cytotoxicity; 50% effective concentrations (ED50) of citrusinine-I were 0.56 micrograms/ml and 0.74 m...

journal_title：Antiviral research

authors： Yamamoto N,Furukawa H,Ito Y,Yoshida S,Maeno K,Nishiyama Y

更新日期：1989-08-01 00:00:00

abstract：:Infections by dengue virus (DENV) are increasing worldwide, with an urgent need for effective anti-DENV agents. We recently identified N-(4-hydroxyphenyl) retinamide (4-HPR), an anti-DENV agent effective against all 4 serotypes of DENV in cell culture, and in a lethal mouse model for DENV infection (Fraser et al., 201...

journal_title：Antiviral research

authors： Fraser JE,Wang C,Chan KW,Vasudevan SG,Jans DA

更新日期：2016-06-01 00:00:00

abstract：:Previous studies of IFN-stimulated transcription factors in murine cells have identified a variety of trans-acting factors that bind to the IFN-stimulated response element (ISRE) whose role in gene expression remain unclear. The present investigation was undertaken to delineate the signal transduction pathway as well ...

journal_title：Antiviral research

authors： Kalvakolanu DV,Mannino SB,Thornton A,Ozato K,Borden EC

更新日期：1994-10-01 00:00:00

abstract：:Buffalopox virus, a zoonotic Indian vaccinia-like virus, is responsible for contagious disease affecting mainly buffaloes, cattle and humans. H3L gene, encoding for an immunodominant major envelope protein of intracellular mature virion of orthopoxviruses, is highly conserved and found to elicit neutralizing antibodie...

journal_title：Antiviral research

authors： Kumar A,Yogisharadhya R,Venkatesan G,Bhanuprakash V,Shivachandra SB

更新日期：2016-02-01 00:00:00

abstract：:Lack of vaccines and efficient control measures complicate the control and eradication of African swine fever (ASF). Limitations of conventional inactivated and attenuated virus-based vaccines against African swine fever virus (ASFV) highlight the need to use new technologies to develop efficient and safe vaccines aga...

journal_title：Antiviral research

authors： Argilaguet JM,Pérez-Martín E,López S,Goethe M,Escribano JM,Giesow K,Keil GM,Rodríguez F

更新日期：2013-04-01 00:00:00

abstract：:Stavudine (d4T) is used extensively as part of HAART in resource poor settings, despite its toxicities. The revised WHO guidelines specify replacement of d4T with less toxic but more expensive drugs when feasible, and that d4T doses be standardized to 30 mg twice daily (bid) (irrespective of body-weight), from the app...

journal_title：Antiviral research

authors： Hurwitz SJ,Schinazi RF

更新日期：2011-11-01 00:00:00

abstract：:Nipah and Hendra virus are members of a newly identified genus of emerging paramyxoviruses, the henipaviruses. Both viruses have the ability to cause severe pulmonary infection and severe acute encephalitis. Following their discovery in the 1990s, outbreaks caused by these zoonotic paramyxoviruses have been associated...

journal_title：Antiviral research

authors： Rockx B,Winegar R,Freiberg AN

更新日期：2012-08-01 00:00:00

abstract：:The hepatitis B virus nucleocapsid or core antigen is extremely immunogenic during infection and after immunization. This review summarizes several features of the nucleocapsid which explain this exceptionally high immunogenicity: a unique three-dimensional folding, the presence of a region that interacts with immunog...

journal_title：Antiviral research

authors： Vanlandschoot P,Cao T,Leroux-Roels G

更新日期：2003-10-01 00:00:00

abstract：:Drug resistance resulting from reverse transcriptase (RT) mutations is one of the main obstacles to successful hepatitis B virus (HBV) therapy. Indeed, HBV treatment guidelines recommend HBV genotypic resistance testing for patients receiving nucleos(t)ide RT inhibitors (N(t)RTIs) who develop virological failure. N(t)...

journal_title：Antiviral research

authors： Rhee SY,Margeridon-Thermet S,Nguyen MH,Liu TF,Kagan RM,Beggel B,Verheyen J,Kaiser R,Shafer RW

更新日期：2010-12-01 00:00:00

abstract：:Sulfated derivatives of paramylon, a water-insoluble (1-3)-beta-D-glucan from Euglena gracilis, significantly inhibited the cytopathic effect of human immunodeficiency virus (HIV-1, HIV-2) and the expression of HIV antigen in cultured MT-4, MOLT-4 cells and human peripheral blood mononuclear cells. Native paramylon, N...

journal_title：Antiviral research

authors： Koizumi N,Sakagami H,Utsumi A,Fujinaga S,Takeda M,Asano K,Sugawara I,Ichikawa S,Kondo H,Mori S

更新日期：1993-05-01 00:00:00

abstract：:Resveratrol (RV), a polyphenolic natural product present in many plants and fruits, exhibits anti-inflammatory, cardio-protective and anti-proliferative properties. Moreover, RV affects a wide variety of viruses including members of the Herpesviridae family, retroviruses, influenza A virus and polyomavirus by altering...

journal_title：Antiviral research

authors： De Leo A,Arena G,Lacanna E,Oliviero G,Colavita F,Mattia E

更新日期：2012-11-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection remains a global health problem, causing nearly one million deaths annually. Forkhead box O (FoxO) transcription factors play important roles in modulating diverse physiological processes. Recent studies show that FoxOs are involved in antiviral responses. In present investigation, we...

journal_title：Antiviral research

authors： Li L,Li Y,Xiong Z,Shu W,Yang Y,Guo Z,Gao B

更新日期：2019-10-01 00:00:00

abstract：:The internal ribosome entry site (IRES) of hepatitis C virus (HCV) which governs the initiation of protein synthesis from viral RNA represents an ideal target for antisense approaches. Using an original bicistronic plasmid, we first established that sequence and translational activity of HCV IRESs cloned from six pati...

journal_title：Antiviral research

authors： Alotte C,Martin A,Caldarelli SA,Di Giorgio A,Condom R,Zoulim F,Durantel D,Hantz O

更新日期：2008-12-01 00:00:00

abstract：:Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) and reduces the risk of cytomegalovirus (CMV) infection in transplant recipients. Everolimus inhibits mTOR complex 1, which regulates factors involved in several crucial cellular functions and is required for CMV replication. However, it is not clear h...

journal_title：Antiviral research

authors： Tan L,Sato N,Shiraki A,Yanagita M,Yoshida Y,Takemura Y,Shiraki K

更新日期：2019-02-01 00:00:00

abstract：:Tea is the second most consumed drink in the world. The beneficial effects of tea have been mostly attributed to its catechin content. Black tea is derived from the leaves of Camellia sinensis plant, and it is rich in theaflavin polyphenols, in particular theaflavin (TF1), theaflavin-3-monogallate (TF2A), theaflavin-3...

journal_title：Antiviral research

authors： de Oliveira A,Prince D,Lo CY,Lee LH,Chu TC

更新日期：2015-06-01 00:00:00

abstract：:Several novel γ-carboline derivatives were identified as selective inhibitors of bovine viral diarrhea virus (BVDV) replication in cell cultures. Among them, 3,4,5-trimethyl-γ-carboline (SK3M4M5M) was the most active against BVDV (Nose strain) in MDBK cells, with a 50% effective concentration of 0.017±0.005μM and a se...

journal_title：Antiviral research

authors： Salim MT,Goto Y,Hamasaki T,Okamoto M,Aoyama H,Hashimoto Y,Musiu S,Paeshuyse J,Neyts J,Froeyen M,Herdewijn P,Baba M

更新日期：2010-12-01 00:00:00

abstract：:JNJ63623872 (formerly known as VX-787) is an inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit. This interaction blocks the cap-snatching activity of the virus that is essential for virus replication. Previously published work has documented antiviral activity of JNJ63623872 in ...

journal_title：Antiviral research

authors： Smee DF,Barnard DL,Jones SM

更新日期：2016-12-01 00:00:00

abstract：:Imexon (4-imino-1,4-diazobicyclo-3.1.0-hexan-2-one) was moderately effective in the treatment of a retroviral infection in a genetically defined murine model. The animal model consisted of a Friend virus complex (FV) infection in a hybrid mouse strain, (B10.A x A/WySn)F1, which has similarities with acquired immune de...

journal_title：Antiviral research

authors： Morrey JD,Warren RP,Okleberry KM,Burger RA,Chirigos MA,Sidwell RW

更新日期：1991-01-01 00:00:00

abstract：:Pritelivir, a helicase-primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV type 1 or 2, including acyclovir-resistant strains, were treated 72 h after infection for 7 days with pritelivir or acyclovir. Both drugs were administered ora...

journal_title：Antiviral research

authors： Quenelle DC,Birkmann A,Goldner T,Pfaff T,Zimmermann H,Bonsmann S,Collins DJ,Rice TL,Prichard MN

更新日期：2018-01-01 00:00:00

abstract：:The EIAV (equine infectious anemia virus) multi-species attenuated vaccine EIAV(DLV121) successfully prevented the spread of equine infectious anemia (EIA) in China in the 1970s and provided an excellent model for the study of protective immunity to lentiviruses. In this study, we compared immune responses induced by ...

journal_title：Antiviral research

authors： Lin YZ,Shen RX,Zhu ZY,Deng XL,Cao XZ,Wang XF,Ma J,Jiang CG,Zhao LP,Lv XL,Shao YM,Zhou JH

更新日期：2011-11-01 00:00:00

abstract：:Although highly active anti-retroviral therapy (HAART) is successful in the treatment of HIV infection, problems with toxicity, drug-resistant variants, and therapeutic failures have compromised the long-term utility of existing combination regimens. Mismatched double-stranded RNA (polyI-polyC(12)U) is an immune modul...

journal_title：Antiviral research

authors： Essey RJ,McDougall BR,Robinson WE Jr

更新日期：2001-09-01 00:00:00

abstract：:Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus ti...

journal_title：Antiviral research

authors： Field HJ

更新日期：1985-06-01 00:00:00

abstract：:An estimated 15-20 million individuals are co-infected by hepatitis B and hepatitis D virus worldwide and are at high risk of developing end-stage liver disease, including hepatocellular carcinoma. While HBV viremia can now be controlled in the vast majority of individuals by nucleoside analogs, leading to a delay of ...

journal_title：Antiviral research

authors： Alfaiate D,Dény P,Durantel D

更新日期：2015-10-01 00:00:00

abstract：:Infection of captive macaques with simian immunodeficiency virus (SIV) and domestic cats with feline immunodeficiency virus (FIV), both discovered in the last five years, represent excellent animal models for infection of humans with the human immunodeficiency virus (HIV). Protection against challenge infection and pr...

journal_title：Antiviral research

authors： Gardner MB

更新日期：1991-05-01 00:00:00

abstract：:We have investigated the inhibitory effect of trans-cinnamaldehyde (CA), one of the principal constituents of essential oil derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo. When 1-h drug treatment was initiated at various times post-infection (p.i.) in Madin-Darby canine kid...

journal_title：Antiviral research

authors： Hayashi K,Imanishi N,Kashiwayama Y,Kawano A,Terasawa K,Shimada Y,Ochiai H

更新日期：2007-04-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the major cause for respiratory tract disease in infants and young children. Currently, no licensed vaccine or a selective antiviral drug against RSV infections are available. Here, we describe a structure-based drug design approach that led to the synthesis of a novel series of zi...

journal_title：Antiviral research

authors： Cancellieri M,Bassetto M,Widjaja I,van Kuppeveld F,de Haan CA,Brancale A

更新日期：2015-10-01 00:00:00

abstract：:High-throughput genomic methods are now being used to study a wide variety of viral diseases, in an effort to understand how host responses to infection can lead either to efficient elimination of the pathogen or the development of severe disease. This article reviews how gene expression studies are addressing importa...

journal_title：Antiviral research

authors： Walters KA,Katze MG

更新日期：2009-03-01 00:00:00

abstract：:The aminoadamantanes, amantadine and rimantadine, have been used to prevent and treat influenza A virus infections for many years. Several reports have shown an increased level of resistance to these drugs, particularly among influenza A(H3N2) subtype viruses, during recent years. We observed an increase in amantadine...

journal_title：Antiviral research

authors： Yavarian J,Azad TM,Zheng X,Gregory V,Lin YP,Hay A

更新日期：2010-11-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals. We have reported (Cubillos et al., 2008) that a synthetic dendrimeric peptide consisting of four copies of a B-cell epitope [VP1(136-154)] linked through thioether bonds to a T-cell epitope [3A(21-35)] of FMDV [B4T(thi)] e...

journal_title：Antiviral research

authors： Blanco E,Guerra B,de la Torre BG,Defaus S,Dekker A,Andreu D,Sobrino F

更新日期：2016-05-01 00:00:00

abstract：:The 30th International Conference on Antiviral Research (ICAR) was held in Atlanta, GA, USA from May 18 to 21, 2017. This report provides an account of award lectures, invited keynote addresses and oral presentations during the meeting. The 2017 Gertrude Elion Memorial Lecture Award by Michael Sofia highlighted one of...

journal_title：Antiviral research

authors： Andrei G,Carter K,Janeba Z,Sampath A,Schang LM,Tarbet EB,Vere Hodge RA,Bray M,Esté JA

更新日期：2017-09-01 00:00:00