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Emetine protects mice from enterovirus infection by inhibiting viral translation.

Abstract：

:IRES-driven translation plays an essential role in picornavirus infection. However, there are seldom reports of compounds targeting this pathway with effective protection in animal models. Here, we identified emetine, an antiprotozoal drug, which inhibits EV-A71 with an EC50 value of 0.04 μM and a CC50 value of 10 μM in RD cell culture. Interestingly, emetine exhibits activities against a series of human enteroviruses, including CV-A16, CV-B1, EV-D68, Echov-6, etc., at the nanomolar level. When orally administered at 0.20 mg/kg twice a day in an EV-A71 mouse model, emetine reduced viral loads in various organs and completely prevented diseases and death. A mechanistic study demonstrated that emetine suppressed EV-A71 by inhibiting viral IRES-driven translation. Taken together, these data indicate emetine as a promising candidate to treat picornavirus infection.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Tang Q,Li S,Du L,Chen S,Gao J,Cai Y,Xu Z,Zhao Z,Lan K,Wu S

doi

10.1016/j.antiviral.2019.104650

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

104650

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(19)30495-4

journal_volume

173

pub_type

杂志文章

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