Abstract：
:Herpes simplex virus-1 (HSV-1) infection is known to cause skin blisters, keratitis as well as deadly cases of encephalitis in some situations. Only a few therapeutic modalities are available for this globally prevalent infection. Very recently, a small molecule BX795 was identified as an inhibitor of HSV-1 protein synthesis in an ocular model of infection. In order to demonstrate its broader antiviral benefits, this study was aimed at evaluating the antiviral efficacy, mode-of-action, and toxicity of BX795 against HSV-1 infection of three human cell lines: HeLa, HEK, and HCE. Several different assays, including cell survival analysis, imaging, plaque analysis, Immunoblotting, and qRT-PCR, were performed. In all cases, BX795 demonstrated low toxicity at therapeutic concentration and showed strong antiviral benefits. Quite interestingly, cell line-dependent differences in the mechanism of antiviral action and cytokine response to infection were seen upon BX795 treatment. Taken together, our results suggest that BX795 may exert its antiviral benefits via cell-line specific mechanisms.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Iqbal A,Suryawanshi R,Yadavalli T,Volety I,Shukla Ddoi
10.1016/j.antiviral.2020.104814subject
Has Abstractpub_date
2020-08-01 00:00:00pages
104814eissn
0166-3542issn
1872-9096pii
S0166-3542(20)30228-Xjournal_volume
180pub_type
杂志文章abstract：:Foot and mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. Previously, we found that the epitope peptide EP141-160 displayed on virus-like particles (VLP) for use as a vaccine showed high immunoreactivity and conferred partially effective protection to animals. In this study, we first ...
journal_title：Antiviral research
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更新日期：2012-11-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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doi：10.1016/j.antiviral.2007.01.003
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-07-01 00:00:00
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更新日期：2010-01-01 00:00:00
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journal_title：Antiviral research
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