Abstract：
:Hepatitis B virus (HBV) infection remains a global health problem, causing nearly one million deaths annually. Forkhead box O (FoxO) transcription factors play important roles in modulating diverse physiological processes. Recent studies show that FoxOs are involved in antiviral responses. In present investigation, we found that HBV induced significant down-regulation of FoxO4 protein, while had little effect on the expression of FoxO1 and FoxO3. Further study showed that FoxO4 displayed inhibitory effect on HBV transcription and replication both in vitro and in vivo. Mechanistically, it was found that FoxO4 exerted its anti-HBV activity by targeting HBV core promoter. Further, FoxO4 was revealed to inhibit HBV core promoter activity via downregulating hepatocyte nuclear factor-4α (HNF4α), and ERK signaling was required for FoxO4-mediated suppression of HNF4α and HBV core promoter activity. Together, these data indicated that FoxO4 displayed anti-HBV activity by suppressing HNF4α expression via activation of ERK pathway, and targeting FoxO4 might present as a novel therapeutic strategy against HBV infection.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Li L,Li Y,Xiong Z,Shu W,Yang Y,Guo Z,Gao Bdoi
10.1016/j.antiviral.2019.104568subject
Has Abstractpub_date
2019-10-01 00:00:00pages
104568eissn
0166-3542issn
1872-9096pii
S0166-3542(18)30586-2journal_volume
170pub_type
杂志文章abstract：:Oligodeoxynucleotides (ODNs) composed entirely of deoxyguanosine and thymidine, but not specifically designed to act as antisense agents, were able to significantly inhibit herpes simplex virus growth in acute infection assay systems. The guanosine/thymidine (GT) ODNs which demonstrated this antiviral activity contain...
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更新日期：1995-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1994-05-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2018.05.010
更新日期：2018-08-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：2017-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-05-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2010.03.002
更新日期：2010-06-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2015-02-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-07-01 00:00:00
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更新日期：2020-01-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2015.01.012
更新日期：2015-04-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2012.12.011
更新日期：2013-03-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2012.05.008
更新日期：2012-08-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.08.026
更新日期：2013-11-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2016.07.017
更新日期：2016-09-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2011.07.017
更新日期：2011-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0166-3542(93)90091-v
更新日期：1993-10-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2007.03.004
更新日期：2007-09-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2013.06.011
更新日期：2013-09-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2012.05.017
更新日期：2012-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1999-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2011.06.014
更新日期：2011-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0166-3542(96)06966-5
更新日期：1996-07-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.09.005
更新日期：2013-11-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(95)00955-8
更新日期：1996-08-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(95)00053-4
更新日期：1995-12-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(83)90016-5
更新日期：1983-03-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(91)90060-5
更新日期：1991-07-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2004.09.005
更新日期：2005-01-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2019.06.002
更新日期：2019-08-01 00:00:00
