Abstract：
:EV71 is a major causative agent of hand, foot and mouth disease (HFMD) and is responsible for large outbreaks in various Asian Pacific countries. In the present study, we generated the recombinant baculovirus (Bac-VP1) encoding VP1 in a novel expression cassette. The transmembrane domain of hemagglutinin of the H3N2 influenza virus was included in the cassette as a minimal membrane anchor for VP1. The protective immunity of Bac-VP1 was investigated in a mouse model. The results showed that mice vaccinated with live Bac-VP1 had strong VP1 specific antibody responses. In an in vitro neutralization assay Bac-VP1 sera exhibited cross-neutralization against homologous and heterologous EV71 strains with a maximum titer of 1:512. Passive immunization studies confirmed that these sera were able to provide 100% protection against 5 MLD(50) of mouse adapted EV71 (B4 strain). This study revealed that baculovirus displaying VP1 with a HA transmembrane domain efficiently induced cross-neutralizing antibody responses in mice.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Premanand B,Kiener TK,Meng T,Tan YR,Jia Q,Chow VT,Kwang Jdoi
10.1016/j.antiviral.2012.05.017subject
Has Abstractpub_date
2012-09-01 00:00:00pages
311-5issue
3eissn
0166-3542issn
1872-9096pii
S0166-3542(12)00132-5journal_volume
95pub_type
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