3',5'Di-O-trityluridine inhibits in vitro flavivirus replication.

abstract：:Ampligen, a known immunomodulator and interferon inducer, was used alone and in combination with other antiviral agents to treat ducks congenitally-infected with duck hepatitis B virus. These antiviral agents included the conventional nucleoside analogue ganciclovir and the prokaryotic DNA gyrase B inhibitor coumermyc...

journal_title：Antiviral research

authors： Niu J,Wang Y,Dixon R,Bowden S,Qiao M,Einck L,Locarnini S

更新日期：1993-06-01 00:00:00

abstract：:While the combination of zidovudine and didanosine is used in HIV-infected patients with more advanced disease, the possibility of a pharmacokinetic interaction between these two drugs remains controversial. Zidovudine doses of 50, 100, and 200 mg, combined with 67, 167, and 250 mg of didanosine were evaluated in 11 a...

journal_title：Antiviral research

authors： Morse GD,Shelton MJ,Ho M,Bartos L,DeRemer M,Ragni M

更新日期：1995-08-01 00:00:00

abstract：:Imexon (4-imino-1,4-diazobicyclo-3.1.0-hexan-2-one) was moderately effective in the treatment of a retroviral infection in a genetically defined murine model. The animal model consisted of a Friend virus complex (FV) infection in a hybrid mouse strain, (B10.A x A/WySn)F1, which has similarities with acquired immune de...

journal_title：Antiviral research

authors： Morrey JD,Warren RP,Okleberry KM,Burger RA,Chirigos MA,Sidwell RW

更新日期：1991-01-01 00:00:00

abstract：:Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) are the two major causative agents of hand, foot and mouth disease (HFMD), for which there are currently no licenced treatments. Here, the acquisition of resistance towards two novel capsid-binding compounds, NLD and ALD, was studied and compared to the analogous co...

journal_title：Antiviral research

authors： Kelly JT,De Colibus L,Elliott L,Fry EE,Stuart DI,Rowlands DJ,Stonehouse NJ

更新日期：2015-12-01 00:00:00

abstract：:Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) may result in a number of different clinical outcomes. There is strong evidence in HBV infection that host genetic factors play a major role in determining the outcome of infection. A number of approaches may be used to determine the specific genetic fa...

journal_title：Antiviral research

authors： Thursz M

更新日期：2001-11-01 00:00:00

abstract：:We report the design, synthesis, and biological evaluation of a class of 1H-pyrido[2,1-b][1,3]benzothiazol-1-ones originated from compound 1, previously identified as anti-flavivirus agent. Some of the new compounds showed activity in low μM range with reasonable selectivity against Dengue 2, Yellow fever (Bolivia str...

journal_title：Antiviral research

authors： Cannalire R,Tarantino D,Piorkowski G,Carletti T,Massari S,Felicetti T,Barreca ML,Sabatini S,Tabarrini O,Marcello A,Milani M,Cecchetti V,Mastrangelo E,Manfroni G,Querat G

更新日期：2019-07-01 00:00:00

abstract：:A recombinant baculovirus (vAc-gC1) was constructed that expresses the glycoprotein C (gC) gene of herpes simplex virus type 1 (HSV-1). When Sf9 cells were infected with this recombinant, a protein that was smaller in size than authentic HSV-1 gC was detected by Western blotting using anti-gC polyclonal antibody. The ...

journal_title：Antiviral research

authors： Ghiasi H,Kaiwar R,Nesburn AB,Wechsler SL

更新日期：1992-06-01 00:00:00

abstract：:Forty-nine subjects were enrolled in a study comparing two dosages of parenterally administered interferon (IFN)-beta in combination with cryotherapy for the treatment of anogenital warts. Subjects were randomized to receive subcutaneous injections of either 2 x 10(6) or 4 x 10(6) IU/m2 of IFN-beta (Biogen) three time...

journal_title：Antiviral research

authors： Bonnez W,Oakes D,Bailey-Farchione A,Choi A,Hallahan D,Corey L,Barnum G,Pappas PG,Halloway M,Stoler MH,Reichman RC

更新日期：1997-06-01 00:00:00

abstract：:We studied susceptibility to herpes labialis by exposing 20 volunteers to experimental ultraviolet radiation (UVR) on three occasions at 3- to 4-month intervals. The number of patients who developed lesions after each session was 9/20 (45%), 9/20 (45%) and 14/20 (70%). Herpes simplex virus (HSV) was isolated from 21/2...

journal_title：Antiviral research

authors： Spruance SL,Kriesel JD,Evans TG,McKeough MB

更新日期：1995-09-01 00:00:00

abstract：:Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. In this study, germacrone, which is a major component of the ...

journal_title：Antiviral research

authors： Liao Q,Qian Z,Liu R,An L,Chen X

更新日期：2013-12-01 00:00:00

abstract：:The identification of more effective and less toxic foscarnet (PFA) analogs for antiviral therapy would be useful. We recently synthesized 1-O-octadecyl-sn-glycero-3-phosphonoformic acid (ODG-PFA) and noted a 93-fold increase in its anti-HCMV activity relative to PFA. In addition, the antiviral activity of ODG-PFA in ...

journal_title：Antiviral research

authors： Kini GD,Beadle JR,Xie H,Aldern KA,Richman DD,Hostetler KY

更新日期：1997-09-01 00:00:00

abstract：:Development of efficient and safer vaccines against foot-and-mouth disease virus (FMDV) is a must. Previous results obtained in our laboratory have demonstrated that DNA vaccines encoding B and T cell epitopes from type C FMDV, efficiently controlled virus replication in mice, while they did not protect against FMDV c...

journal_title：Antiviral research

authors： Borrego B,Argilaguet JM,Pérez-Martín E,Dominguez J,Pérez-Filgueira M,Escribano JM,Sobrino F,Rodriguez F

更新日期：2011-11-01 00:00:00

abstract：:The TC-83 vaccine strain of Venezuelan equine encephalitis virus (VEEV) causes encephalitis and death in C3H/HeN mice infected by intranasal (i.n.) instillation. Since TC-83 is exempt as a select agent, this mouse model was used in the evaluation of antiviral therapies. Virus titers in the brains of infected mice peak...

journal_title：Antiviral research

authors： Julander JG,Skirpstunas R,Siddharthan V,Shafer K,Hoopes JD,Smee DF,Morrey JD

更新日期：2008-06-01 00:00:00

abstract：:Acute lower respiratory tract infections (ALRI) caused by respiratory syncytial virus (RSV) are associated with a severe disease burden among infants and elderly patients. Treatment options are limited. While numerous drug candidates with different viral targets are under development, the utility of RSV entry inhibito...

journal_title：Antiviral research

authors： Blockus S,Sake SM,Wetzke M,Grethe C,Graalmann T,Pils M,Le Goffic R,Galloux M,Prochnow H,Rox K,Hüttel S,Rupcic Z,Wiegmann B,Dijkman R,Rameix-Welti MA,Eléouët JF,Duprex WP,Thiel V,Hansen G,Brönstrup M,Haid S,Piets

更新日期：2020-05-01 00:00:00

abstract：:Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded R...

journal_title：Antiviral research

authors： Prasanth KR,Hirano M,Fagg WS,McAnarney ET,Shan C,Xie X,Hage A,Pietzsch CA,Bukreyev A,Rajsbaum R,Shi PY,Bedford MT,Bradrick SS,Menachery V,Garcia-Blanco MA

更新日期：2020-10-01 00:00:00

abstract：:Human parainfluenza virus type 3 (HPIV3) is an important respiratory tract pathogen of infants and children. There are no vaccines or antivirals currently approved for prevention or treatment of HPIV3 infection. Towards developing an antiviral therapy to combat HPIV3 infection, we have established a green fluorescent ...

journal_title：Antiviral research

authors： Mao H,Thakur CS,Chattopadhyay S,Silverman RH,Gudkov A,Banerjee AK

更新日期：2008-02-01 00:00:00

abstract：:T Follicular helper cells (TFH) are considered critical for B cell antibody response, and recent efforts have focused on promoting TFH in order to enhance vaccine efficacy. We studied the frequency and function of TFH in nasopharynx-associated lymphoid tissues (NALT) from children and adults, and its role in anti-infl...

journal_title：Antiviral research

authors： Aljurayyan AN,Sharma R,Upile N,Beer H,Vaughan C,Xie C,Achar P,Ahmed MS,McNamara PS,Gordon SB,Zhang Q

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND/AIMS:Traditional Chinese herbal therapies are widely used for the treatment of chronic hepatitis C (CHC) in Asia. The aim of this study was to perform a meta-analysis of randomised controlled trials (RCTs) comparing interferon therapies with Chinese herbal therapies and/or interferon plus Chinese herb therap...

journal_title：Antiviral research

authors： Zhao S,Liu E,Wei K,Lu S,Chu Y,Li Y,Wang Y,Huang B,Chen Y,Yang P

更新日期：2011-02-01 00:00:00

abstract：:Rabies is a lethal viral infection that can affect almost all mammals, including humans. To better understand the replication of Rabies lyssavirus, we investigated if the viral load in brains naturally infected with rabies influences viral internalization and viral growth kinetics in neuroblastoma cells, and if the vi...

journal_title：Antiviral research

authors： Fuoco NL,Dos Ramos Silva S,Fernandes ER,Luiz FG,Ribeiro OG,Katz ISS

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Lactoferrin (LF) is a glycoprotein present in human milk with known antimicrobial effects. In vitro, LF has demonstrated antiviral activity against respiratory syncytial virus (RSV). We sought to assess the effect of bovine (b)LF in RSV replication, lung inflammation and function, cytokine profiles and clini...

journal_title：Antiviral research

authors： Gualdi L,Mertz S,Gomez AM,Ramilo O,Wittke A,Mejias A

更新日期：2013-08-01 00:00:00

abstract：:To identify monoclonal antibodies (mAbs) with high potency and novel recognition sites, more than 25,000 of mouse hybridomas were screened and 4 novel anti-human CCR5 mAbs ROAb12, ROAb13, ROAb14, and ROAb18 showing potent activity in cell-cell fusion (CCF) assay were identified. These mAbs demonstrated potent antivira...

journal_title：Antiviral research

authors： Ji C,Brandt M,Dioszegi M,Jekle A,Schwoerer S,Challand S,Zhang J,Chen Y,Zautke L,Achhammer G,Baehner M,Kroetz S,Heilek-Snyder G,Schumacher R,Cammack N,Sankuratri S

更新日期：2007-05-01 00:00:00

abstract：:Although canine rabies has been eliminated from industrialized countries, infected dogs remain the primary source of human and livestock exposures in Asia, Africa and much of South America. Human deaths are the most important direct economic impact of canine rabies, followed by livestock losses and the cost of PEP, wh...

journal_title：Antiviral research

authors： Shwiff S,Hampson K,Anderson A

更新日期：2013-05-01 00:00:00

abstract：:The introduction of potent combination therapies in the mid-90s had a tremendous effect on AIDS mortality. However, drug resistance has been a major factor contributing to antiretroviral therapy failure. Currently, there are 26 drugs approved for treating human immunodeficiency virus (HIV) infections, although some of...

journal_title：Antiviral research

authors： Menéndez-Arias L

更新日期：2013-04-01 00:00:00

abstract：:Oxymatrine (OMTR) is an anti-hepatitis drug used in China. Its mechanism of action is unknown. Recently, we found that OMTR inhibits hepatitis B virus (HBV) via down-regulating the expression of heat-stress cognate 70 (Hsc70), a host protein required for HBV DNA replication. Goal of this study was to assess the effect...

journal_title：Antiviral research

authors： Wang YP,Zhao W,Xue R,Zhou ZX,Liu F,Han YX,Ren G,Peng ZG,Cen S,Chen HS,Li YH,Jiang JD

更新日期：2011-03-01 00:00:00

abstract：:Mycophenolate mofetil (MMF), a therapeutically used inhibitor of inosine monophosphate dehydrogenase is hydrolyzed to its active metabolite mycophenolic acid (MPA) in vivo. MPA exhibits anti-HIV activity in vitro. We tested MPA alone and in combination with abacavir (ABC), didanosine (DDI), lamivudine (3TC) and tenofo...

journal_title：Antiviral research

authors： Hossain MM,Coull JJ,Drusano GL,Margolis DM

更新日期：2002-07-01 00:00:00

abstract：:Human CMV causes a number of diseases that cause considerable morbidity and that can be life-threatening in immunocompromised patients, particularly those with AIDS. Ganciclovir (GCV) and Foscarnet (PFA) are currently the drugs of choice for management of CMV disease. Both are not without side effects and have a relat...

journal_title：Antiviral research

authors： Nokta M,Tolpin MD,Nadler PI,Pollard RB

更新日期：1994-05-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infections cause congenital birth defects and disease in immunosuppressed individuals. Antiviral compounds can control infection yet their use is restricted due to concerns of toxicity and the emergence of drug resistant strains. We have evaluated the impact of an RNA Polymerase I (Pol I) ...

journal_title：Antiviral research

authors： Westdorp KN,Terhune SS

更新日期：2018-05-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is an arbovirus transmitted to humans by mosquito bite. A decade ago, the virus caused a major outbreak in the islands of the Indian Ocean, then reached India and Southeast Asia. More recently, CHIKV has emerged in the Americas, first reaching the Caribbean and now extending to Central, South...

journal_title：Antiviral research

authors： Couderc T,Lecuit M

更新日期：2015-09-01 00:00:00

abstract：:Foot-and-mouth disease is a viral illness that affects cloven-hoofed animals causing serious economic losses. Inactivated vaccines against its causative agent, foot-and-mouth disease virus (FMDV), require approximately seven days to induce protection. Therefore, antiviral strategies are needed to provide earlier prote...

journal_title：Antiviral research

authors： Molina GN,Cacciabue M,Gismondi MI,Taboga O,Molinari P

更新日期：2020-08-01 00:00:00

abstract：:The bovine immunodeficiency virus (BIV) and human immunodeficiency virus types 1 and 2 (HIV-1 and -2) are members of the lentivirus genus of retroviruses. Although DNA sequences of these viruses have diverged considerably, the BIV genome organization, function of structural and regulatory genes, and replication cycle ...

journal_title：Antiviral research

authors： Tobin GJ,Ennis WH,Clanton DJ,Gonda MA

更新日期：1996-12-01 00:00:00