Abstract:
:Development of anti-dengue therapy represents an urgent un-met medical need. Towards antiviral therapy, recent advances in crystal structures of DENV enzymes have led to the possibility of structure-based rational design of inhibitors for anti-dengue therapy. These include (i) the structure of the 'active' form of the DENV protease in complex with a peptide substrate; (ii) the structure of DENV methyltransferase bound to an inhibitor that selectively suppresses viral methyltransferase, but not human methyltransferases; (iii) the structure of DENV RNA-dependent RNA polymerase in complex with a small-molecule compound. This review summarizes the structural biology of these three key enzymes (protease, methyltransferase, and polymerase) that are essential for DENV replication. The new structural information has provided new avenues for development of anti-dengue therapy.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Noble CG,Shi PYdoi
10.1016/j.antiviral.2012.09.007subject
Has Abstractpub_date
2012-11-01 00:00:00pages
115-26issue
2eissn
0166-3542issn
1872-9096pii
S0166-3542(12)00204-5journal_volume
96pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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