Effective siRNAs inhibit the replication of novel influenza A (H1N1) virus.

abstract：:Chikungunya virus (CHIKV) is an arbovirus transmitted to humans by mosquito bite. A decade ago, the virus caused a major outbreak in the islands of the Indian Ocean, then reached India and Southeast Asia. More recently, CHIKV has emerged in the Americas, first reaching the Caribbean and now extending to Central, South...

journal_title：Antiviral research

authors： Couderc T,Lecuit M

更新日期：2015-09-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFr) has been shown to be induced and activated in cells infected with HPV, suggesting that it may play a physiological role in viral replication or in the formation or maintenance of warts. To investigate this possibility, human foreskin tissue was infected with HPV11 and transplant...

journal_title：Antiviral research

authors： Parkinson T,Howett MK,Welsh PA,Patrick SD,Neely EB,Flanagan N,Pollack VA,Pustilnik LR,Moyer J,Perros M

更新日期：2007-04-01 00:00:00

abstract：:A major challenge in the development of vaccines against retroviruses is the induction of neutralizing antibodies since they prevent infection of the cells where the virus may persist. The transmembrane envelope (TM) protein contains highly conserved domains and seems to be a suitable target. To study whether vaccinat...

journal_title：Antiviral research

authors： Langhammer S,Hübner J,Jarrett O,Kurth R,Denner J

更新日期：2011-01-01 00:00:00

abstract：:Brivudin [(E)-5-(2-bromovinyl)-2'-deoxyuridine] is a nucleoside analogue with a high and selective antiviral activity against varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1). The double-blind, randomized study presented here compared efficacy and safety of oral brivudin 1 x 125 mg and acyclovir 5 ...

journal_title：Antiviral research

authors： Wassilew SW,Wutzler P,Brivddin Herpes Zoster Study Group.

更新日期：2003-06-01 00:00:00

abstract：:The latent reservoir of HIV-1 in resting memory CD4+ T cells serves as a major barrier to curing HIV-1 infection. Reactivation of latent HIV-1 is proposed as a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current latency reversal agents (LRAs), identification of new LRAs ...

journal_title：Antiviral research

authors： Yang H,Li X,Yang X,Lu P,Wang Y,Jiang Z,Pan H,Zhao L,Zhu Y,Khan IU,Shen Y,Lu H,Zhang T,Jiang G,Ma Z,Wu H,Zhu H

更新日期：2019-09-01 00:00:00

abstract：:Twenty-five years after the discovery of the therapeutic activity of azidothymidine (AZT), the first antiretroviral drug used in the clinic, infection with the human immunodeficiency virus (HIV) has become, at least in the industrialized world, a manageable chronic disease with a significant improvement in life expect...

journal_title：Antiviral research

authors： Esté JA,Cihlar T

更新日期：2010-01-01 00:00:00

abstract：:Cellular immune responses (T cell responses) during hepatitis C virus (HCV) infection are significant factors for determining the outcome of infection. HCV adapts to host immune responses by inducing mutations in its genome at specific sites that are important for HLA processing/presentation. Moreover, HCV also adapts...

journal_title：Antiviral research

authors： Ikram A,Obaid A,Awan FM,Hanif R,Naz A,Paracha RZ,Ali A,Janjua HA

更新日期：2017-01-01 00:00:00

abstract：:Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded R...

journal_title：Antiviral research

authors： Prasanth KR,Hirano M,Fagg WS,McAnarney ET,Shan C,Xie X,Hage A,Pietzsch CA,Bukreyev A,Rajsbaum R,Shi PY,Bedford MT,Bradrick SS,Menachery V,Garcia-Blanco MA

更新日期：2020-10-01 00:00:00

abstract：:The era of antiviral chemotherapy started more than 50 years with the findings by Domagk and his colleagues that thiosemicarbazones showed activity against vaccinia virus. One of the derivatives, methisazone, was even investigated in the prophylaxis of smallpox. With the successful implementation of the smallpox vacci...

journal_title：Antiviral research

authors： Neyts J,De Clercq E

更新日期：2003-01-01 00:00:00

abstract：:Since 2011, highly pathogenic pseudorabies virus (PRV) variants that emerged on many farms in China have posed major economic burdens to the animal industry and have even recently caused several human cases of viral encephalitis. Currently, there are no approved effective drugs to treat PRV associated diseases in huma...

journal_title：Antiviral research

authors： Wang G,Chen R,Huang P,Hong J,Cao J,Wu Q,Zheng W,Lin L,Han Q,Chen Y,Xia N

更新日期：2021-01-07 00:00:00

abstract：:While the combination of zidovudine and didanosine is used in HIV-infected patients with more advanced disease, the possibility of a pharmacokinetic interaction between these two drugs remains controversial. Zidovudine doses of 50, 100, and 200 mg, combined with 67, 167, and 250 mg of didanosine were evaluated in 11 a...

journal_title：Antiviral research

authors： Morse GD,Shelton MJ,Ho M,Bartos L,DeRemer M,Ragni M

更新日期：1995-08-01 00:00:00

abstract：:A screening for inhibitors of human immunodeficiency virus type 1 (HIV-1) among various types of isopolyoxomolybdates and heteropolyoxomolybdates was carried out by using an in vitro assay system measuring the cytopathogenicity of HIV-1 in CD4+ human MT-4 cells. A novel heteropolyoxomolybdate named PM-104 with the che...

journal_title：Antiviral research

authors： Inouye Y,Tokutake Y,Yoshida T,Seto Y,Hujita H,Dan K,Yamamoto A,Nishiya S,Yamase T,Nakamura S

更新日期：1993-04-01 00:00:00

abstract：:In a previous study a 15-mer phosphorothioate oligonucleotide (S-ON) derived from the packaging signal in the 5' end of segment 1 (PB2) of influenza A virus (designated 5-15b) proved markedly inhibitory to virus replication. Here we investigated whether analogous inhibitory S-ONs targeting the 5' end of segments 2 (PB...

journal_title：Antiviral research

authors： Giannecchini S,Wise HM,Digard P,Clausi V,Del Poggetto E,Vesco L,Puzelli S,Donatelli I,Azzi A

更新日期：2011-10-01 00:00:00

abstract：:The mammarenavirus Lassa (LASV) is highly prevalent in West Africa where it infects several hundred thousand individuals annually resulting in a high number of Lassa fever (LF) cases, a febrile disease associated with high morbidity and significant mortality. Mounting evidence indicates that the worldwide-distributed ...

journal_title：Antiviral research

authors： Cubitt B,Ortiz-Riano E,Cheng BY,Kim YJ,Yeh CD,Chen CZ,Southall NOE,Zheng W,Martinez-Sobrido L,de la Torre JC

更新日期：2020-01-01 00:00:00

abstract：:Middle East Respiratory Syndrome (MERS) is a respiratory disease caused by a coronavirus (MERS-CoV). Since its emergence in 2012, nosocomial amplifications have led to its high epidemic potential and mortality rate of 34.5%. To date, there is an unmet need for vaccines and specific therapeutics for this disease. Avail...

journal_title：Antiviral research

authors： Gan HJ,Harikishore A,Lee J,Jeon S,Rajan S,Chen MW,Neo JL,Kim S,Yoon HS

更新日期：2021-01-01 00:00:00

abstract：:The prevention and control of disease caused by seasonal and potential pandemic influenza viruses is currently managed by the use influenza vaccines and antivirals. The adamantanes (amantadine and rimantadine) were the first antivirals licensed for use against influenza A viruses and have been used extensively in some...

journal_title：Antiviral research

authors： Barr IG,Hurt AC,Iannello P,Tomasov C,Deed N,Komadina N

更新日期：2007-02-01 00:00:00

abstract：:On September 22, 2008, a physician on Prince of Wales Island, Alaska, notified the Alaska Department of Health and Social Services (ADHSS) of an unusually high number of adult patients with recently diagnosed pneumonia (n = 10), including three persons who required hospitalization and one who died. ADHSS and CDC condu...

journal_title：Antiviral research

authors： Kumaki Y,Woolcott JD,Roth JP,Mclean TZ,Smee DF,Barnard DL,Valiaeva N,Beadle JR,Hostetler KY

更新日期：2018-10-01 00:00:00

abstract：:PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir] has shown anti-cytomegalovirus activity in animal models and in preliminary human trials. PMEA diphosphate (PMEApp), the active antiviral metabolite of PMEA, is a potent inhibitor of human cytomegalovirus (HCMV) DNA polymerase. PMEA is efficiently taken up and phos...

journal_title：Antiviral research

authors： Xiong X,Flores C,Fuller MD,Mendel DB,Mulato AS,Moon K,Chen MS,Cherrington JM

更新日期：1997-11-01 00:00:00

abstract：:Natural compounds provide a large reservoir of potentially active anti-hepatitis B virus (HBV) agents. We examined the direct effects of protocatechuic aldehyde (PA; derived from the Chinese herb, Salvia miltiorrhiza) on HBV replication in HepG2 2.2.15 cell line and duck hepatitis B virus (DHBV) replication in ducklin...

journal_title：Antiviral research

authors： Zhou Z,Zhang Y,Ding XR,Chen SH,Yang J,Wang XJ,Jia GL,Chen HS,Bo XC,Wang SQ

更新日期：2007-04-01 00:00:00

abstract：:Pritelivir, a helicase-primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV type 1 or 2, including acyclovir-resistant strains, were treated 72 h after infection for 7 days with pritelivir or acyclovir. Both drugs were administered ora...

journal_title：Antiviral research

authors： Quenelle DC,Birkmann A,Goldner T,Pfaff T,Zimmermann H,Bonsmann S,Collins DJ,Rice TL,Prichard MN

更新日期：2018-01-01 00:00:00

abstract：:MicroRNA-122 (miR-122) is involved in the pathogenesis of several liver diseases, including chronic hepatitis B infection and hepatocellular carcinoma. This study aimed to explore the potential role of miR-122 in the interferon (IFN)-mediated suppression of hepatitis B virus (HBV) in hepatocytes. We found that elevate...

journal_title：Antiviral research

authors： Gao D,Zhai A,Qian J,Li A,Li Y,Song W,Zhao H,Yu X,Wu J,Zhang Q,Kao W,Wei L,Zhang F,Zhong Z

更新日期：2015-06-01 00:00:00

abstract：:Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) may result in a number of different clinical outcomes. There is strong evidence in HBV infection that host genetic factors play a major role in determining the outcome of infection. A number of approaches may be used to determine the specific genetic fa...

journal_title：Antiviral research

authors： Thursz M

更新日期：2001-11-01 00:00:00

abstract：:Many aspects of the biology and epidemiology of influenza B viruses are far less studied than for influenza A viruses, and one of these aspects is efficacy and resistance to the clinically available antiviral drugs, the neuraminidase (NA) inhibitors (NAIs). Acute respiratory infections are one of the leading causes of...

journal_title：Antiviral research

authors： Burnham AJ,Baranovich T,Govorkova EA

更新日期：2013-11-01 00:00:00

abstract：:We have investigated viral breakthrough during a long-term culture of HIV-1-infected cells with the non-nucleoside reverse transcriptase inhibitors (NNRTIs) 6-benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442), nevirapine and loviride (alpha-APA). When the compounds were examined for their inhibitory effects on HIV-1 (...

journal_title：Antiviral research

authors： Okamoto M,Makino M,Yamada K,Nakade K,Yuasa S,Baba M

更新日期：1996-06-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. In immunocompromised patients, KSHV infection is capable of causing severe and fatal diseases. Current antiviral treatments for KSHV infections consist mostly of n...

journal_title：Antiviral research

authors： Chen J,Zhang H,Chen X

更新日期：2020-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a leading cause of chronic hepatitis and end-stage liver diseases. Mature HCV virions are bound by host-derived lipoproteins. Lack of an HCV vaccine warrants a major role of antiviral treatment in the global elimination of hepatitis C. Although direct-acting antivirals (DAAs) are replacing t...

journal_title：Antiviral research

authors： Li X,Li J,Feng Y,Cai H,Li YP,Peng T

更新日期：2020-05-01 00:00:00

abstract：:Currently used antiretroviral therapy is highly successful but there is still a need for new effective and safe prophylactics and therapeutics. We have previously identified and characterized a human engineered antibody domain (eAd), m36, which exhibits potent broadly neutralizing activity against HIV-1 by targeting a...

journal_title：Antiviral research

authors： Chen W,Xiao X,Wang Y,Zhu Z,Dimitrov DS

更新日期：2010-10-01 00:00:00

abstract：:The 21st International Conference on Antiviral Research provided novel insights and approaches to drug discovery across a wide array of virologic fields. Topics ranged from the chemical synthesis of new compounds against the human immunodeficiency virus (HIV) to the long-term use of established drugs against influenza...

journal_title：Antiviral research

authors： Wainberg MA

更新日期：2009-01-01 00:00:00

abstract：:The present study was undertaken to examine the potential of rectal route of immunization for induction of protective immunity in the female genital tract against genital herpes infection in mice. A single rectal immunization of female C57Bl/6 mice with live attenuated herpes simplex virus type 2 lacking thymidine kin...

journal_title：Antiviral research

authors： Tengvall S,O'Hagan D,Harandi AM

更新日期：2008-06-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection remains a global health problem, causing nearly one million deaths annually. Forkhead box O (FoxO) transcription factors play important roles in modulating diverse physiological processes. Recent studies show that FoxOs are involved in antiviral responses. In present investigation, we...

journal_title：Antiviral research

authors： Li L,Li Y,Xiong Z,Shu W,Yang Y,Guo Z,Gao B

更新日期：2019-10-01 00:00:00