Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives.

abstract：:The latent reservoir of HIV-1 in resting memory CD4+ T cells serves as a major barrier to curing HIV-1 infection. Reactivation of latent HIV-1 is proposed as a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current latency reversal agents (LRAs), identification of new LRAs ...

journal_title：Antiviral research

authors： Yang H,Li X,Yang X,Lu P,Wang Y,Jiang Z,Pan H,Zhao L,Zhu Y,Khan IU,Shen Y,Lu H,Zhang T,Jiang G,Ma Z,Wu H,Zhu H

更新日期：2019-09-01 00:00:00

abstract：:In the event of an influenza pandemic, the use of oseltamivir (OTV) will undoubtedly increase and therefore it is more likely that OTV-resistant influenza strains will also arise. OTV-resistance genotyping using sequence-based testing on viruses isolated in cell culture is time consuming and less likely to detect the ...

journal_title：Antiviral research

authors： Steain MC,Dwyer DE,Hurt AC,Kol C,Saksena NK,Cunningham AL,Wang B

更新日期：2009-12-01 00:00:00

abstract：:Since it was discovered as the first human tumor virus in 1964, Epstein-Barr Virus (EBV) is now implicated in several types of malignancies. Accordingly, certain aspects of EBV pathobiology have shown promise in anti-cancer research in developing virus-targeting methods for EBV-associated cancers. The unique role of E...

journal_title：Antiviral research

authors： Shen CL,Huang WH,Hsu HJ,Yang JH,Peng CW

更新日期：2019-04-01 00:00:00

abstract：:HIV-host infection systems in vitro are important in the pre-clinical assessment of anti-retroviral drug activity. The present report describes the development of a new HIV-host model comprised of an epithelial cell line of HeLa lineage (HeLa-1), transfected with expression vectors bearing tat and rev (TART) genes of ...

journal_title：Antiviral research

authors： Moussazadeh M,Hua J,Sidhu MK,Zhao XX,Fitzgibbon JE,Liao MJ,Rashidbaigi A

更新日期：1999-07-01 00:00:00

abstract：:Using an in vitro system we measured the corneal epithelial cytotoxicity and the antiviral activity of the antiviral agents idoxuridine (IDU), trifluridine (TFT), ethyldeoxyuridine (EDU), and (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU). Confluent rabbit corneal epithelial cell cultures were established, and the antivi...

journal_title：Antiviral research

authors： Imperia PS,Lazarus HM,Dunkel EC,Pavan-Langston D,Geary PA,Lass JH

更新日期：1988-07-01 00:00:00

abstract：DESIGN:The HIV latent CD4+ T cell reservoir is broadly recognized as a barrier to HIV cure. Induction of HIV expression using protein kinase C (PKC) agonists is one approach under investigation for reactivation of latently infected CD4+ T cells (Beans et al., 2013; Abreu et al., 2014; Jiang et al., 2014; Jiang and Dand...

journal_title：Antiviral research

authors： Vemula SV,Maxwell JW,Nefedov A,Wan BL,Steve J,Newhard W,Sanchez RI,Tellers D,Barnard RJ,Blair W,Hazuda D,Webber AL,Howell BJ

更新日期：2017-03-01 00:00:00

abstract：:Cell-to-cell contact is usually essential for syncytium formation by HTLV-I-infected cell lines. The present study was undertaken to determine the inhibitory effect of polyanionic compounds, dextran sulfate and heparin, on HTLV-I-induced syncytium formation, as demonstrated by the fusion of HTLV-I-infected cells with ...

journal_title：Antiviral research

authors： Ida H,Kurata A,Eguchi K,Yamashita I,Nakashima M,Sakai M,Kawabe Y,Nakamura T,Nagataki S

更新日期：1994-02-01 00:00:00

abstract：:Carbohydrate-binding proteins (CBP) can be isolated from a variety of species, including procaryotes (i.e. cyanobacteria), sea corals, algae, plants, invertebrates and vertebrates. A number of them, in particular those CBP that show specific recognition for mannose (Man) and N-acetylglucosamine (GlcNAc) are endowed wi...

journal_title：Antiviral research

authors： Balzarini J

更新日期：2006-09-01 00:00:00

abstract：:Several novel γ-carboline derivatives were identified as selective inhibitors of bovine viral diarrhea virus (BVDV) replication in cell cultures. Among them, 3,4,5-trimethyl-γ-carboline (SK3M4M5M) was the most active against BVDV (Nose strain) in MDBK cells, with a 50% effective concentration of 0.017±0.005μM and a se...

journal_title：Antiviral research

authors： Salim MT,Goto Y,Hamasaki T,Okamoto M,Aoyama H,Hashimoto Y,Musiu S,Paeshuyse J,Neyts J,Froeyen M,Herdewijn P,Baba M

更新日期：2010-12-01 00:00:00

abstract：:Preventive intraperitoneal trehalose dimycolate (TDM) treatment of mice, inoculated with encephalomyocarditis (EMC) virus by the same route, caused restriction of virus growth in the peritoneum, which was correlated to IFN production in peritoneal fluids prior to infection. Peritoneal macrophages from TDM-treated mice...

journal_title：Antiviral research

authors： Guillemard E,Geniteau-Legendre M,Kergot R,Lemaire G,Petit JF,Labarre C,Quero AM

更新日期：1995-10-01 00:00:00

abstract：:Each year, up to 10,000 cases of infections with the flavivirus tick-borne encephalitis (TBE) virus that affect the central nervous system are reported in Europe and Asia. Due to the potentially severe adverse effects of post-exposure prophylaxis with TBE virus hyperimmunoglobulin, TBE can currently only be treated sy...

journal_title：Antiviral research

authors： Achazi K,Patel P,Paliwal R,Radonić A,Niedrig M,Donoso-Mantke O

更新日期：2012-01-01 00:00:00

abstract：:Herpesviruses encode a protease that is essential for virus replication. The protease undergoes cleavage to a processed form during capsid maturation. A recombinant 75 kDa form of the protease from human cytomegalovirus was purified and compared with the recombinant 29 kDa processed form. Modification with an active s...

journal_title：Antiviral research

authors： Wittwer AJ,Funckes-Shippy CL,Hippenmeyer PJ

更新日期：2002-08-01 00:00:00

abstract：:The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon alpha, Hu IFN-alpha 2b and Hu IFN-gamma B,D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppresse...

journal_title：Antiviral research

authors： Schellekens H,Niphuis H,Buijs L,Douw van der Krap P,Hochkeppel HK,Heeney JL

更新日期：1996-08-01 00:00:00

abstract：:Previously, we found that a ganciclovir (GCV)-resistant clinical human cytomegalovirus (HCMV) isolate had an amino acid substitution at codon 501 (Leu --> Phe) in the delta-region C of the DNA polymerase gene. DNA polymerases have now been (partially) purified from both the GCV-resistant and sensitive parental strains...

journal_title：Antiviral research

authors： Kariya M,Mori S,Eizuru Y

更新日期：2000-02-01 00:00:00

abstract：:Compounds were evaluated for antiviral activity in rhabdomyosarcoma (RD) cells against a recent 2014 clinical isolate of enterovirus D68 (EV-D68), a 1962 strain of EV-68D, rhinovirus 87 (RV-87, serologically the same as EV-D68), and enterovirus 71 (EV-71). Test substances included known-active antipicornavirus agents ...

journal_title：Antiviral research

authors： Smee DF,Evans WJ,Nicolaou KC,Tarbet EB,Day CW

更新日期：2016-07-01 00:00:00

abstract：:Fifty-nine US isolates of HSV-1 and HSV-2 obtained between 1998 and 2004 were tested for sensitivity to the helicase-primase inhibitor, pritelivir (AIC316, BAY 57-1293) by plaque-reduction assay. All isolates, which were collected prior to any clinical use of primase-helicase inhibitors, were sensitive and showed mean...

journal_title：Antiviral research

authors： Field HJ,Huang ML,Lay EM,Mickleburgh I,Zimmermann H,Birkmann A

更新日期：2013-11-01 00:00:00

abstract：:Influenza virus continues to remain one of the leading human respiratory pathogens causing significant morbidity and mortality around the globe. Due to short-term life cycle and high rate of mutations influenza virus is able to rapidly develop resistance to clinically available antivirals. This makes necessary the sea...

journal_title：Antiviral research

authors： Zarubaev VV,Garshinina AV,Tretiak TS,Fedorova VA,Shtro AA,Sokolova AS,Yarovaya OI,Salakhutdinov NF

更新日期：2015-08-01 00:00:00

abstract：:Prostratin, a non-tumor-promoting phorbol ester, inhibited human immunodeficiency virus (HIV)-induced cell killing and viral replication in a variety of acutely-infected cell systems. The potency and degree of cytoprotection was dependent on both viral strain and host cell type. Prostratin activated viral expression i...

journal_title：Antiviral research

authors： Gulakowski RJ,McMahon JB,Buckheit RW Jr,Gustafson KR,Boyd MR

更新日期：1997-01-01 00:00:00

abstract：:Enterovirus D68 (EV-D68) is a member of the Picornavirus family and a causative agent of respiratory diseases in children. The incidence of EV-D68 infection has increased worldwide in recent years. Thus far, there are no approved antiviral agents or vaccines for EV-D68. Here, we show that methyl-β-cyclodextrin (MβCD),...

journal_title：Antiviral research

authors： Jiang Y,Liu S,Shen S,Guo H,Huang H,Wei W

更新日期：2020-04-01 00:00:00

abstract：:This mosquito-borne pathogen of humans and animals respects no international or geographic boundaries. It is currently found in parts of Africa and the Arabian Peninsula where periodic outbreaks of severe and fatal disease occur, and threatens to spread into other geographic regions. In recent years, modern molecular ...

journal_title：Antiviral research

authors： Bird BH,McElroy AK

更新日期：2016-08-01 00:00:00

abstract：:Site-directed in vitro mutagenesis was used to create analogs of human interferons (IFNs)-alpha 1 and -alpha 4. Analogs were expressed in vitro using SP6 RNA polymerase and a rabbit reticulocyte lysate cell-free protein synthesis system. Amino acid substitutions for the highly conserved residues at positions 33, 121, ...

journal_title：Antiviral research

authors： Tymms MJ,McInnes B,Waine GJ,Cheetham BF,Linnane AW

更新日期：1989-08-01 00:00:00

abstract：:Cyclosporin A (CsA) was assessed for its effect on the production of antiviral activity by human peripheral blood leukocytes (PBL). CsA markedly reduced the production of interferon-gamma (IFN-gamma) in response to stimulation with lectin mitogens, bacterial products, alloantigens, or Epstein-Barr virus (EBV)-transfor...

journal_title：Antiviral research

authors： Abb J,Abb H,Deinhardt F

更新日期：1982-12-01 00:00:00

abstract：:A newly synthesized imide derivative of 3-nitro-1,8-naphthalic acid, 5-amino-2-(2-dimethylaminoethyl)benzo-[de]-isoquinolin-1,3-dione (designated M-FA-142), was tested on chick embryo cells against herpes simplex virus type 1 (HSV-1) and vaccinia virus (VV), and on Vero cells against African swine fever virus (ASFV). ...

journal_title：Antiviral research

authors： García Gancedo A,Gil-Fernández C,Vilas P,Pérez S,Rodriguez F,Paez E,Braña MF,Roldán CM

更新日期：1984-08-01 00:00:00

abstract：:T Follicular helper cells (TFH) are considered critical for B cell antibody response, and recent efforts have focused on promoting TFH in order to enhance vaccine efficacy. We studied the frequency and function of TFH in nasopharynx-associated lymphoid tissues (NALT) from children and adults, and its role in anti-infl...

journal_title：Antiviral research

authors： Aljurayyan AN,Sharma R,Upile N,Beer H,Vaughan C,Xie C,Achar P,Ahmed MS,McNamara PS,Gordon SB,Zhang Q

更新日期：2016-08-01 00:00:00

abstract：:The viral genotype and serum viral level influence the response to interferon (IFN) treatment in patients with chronic hepatitis C virus (HCV) viremia. The aim of this study was to investigate a possible relationship between early virological response and helper T (Th) cell cytokine expansion by 4 weeks of ribavirin (...

journal_title：Antiviral research

authors： Furusyo N,Kubo N,Toyoda K,Takeoka H,Nabeshima S,Murata M,Nakamuta M,Hayashi J

更新日期：2005-07-01 00:00:00

abstract：:Rotavirus infection has emerged as an important cause of complications in organ transplantation recipients. Immunosuppressants used to prevent alloreactivity can also interfere with virus infection, but the direct effects of the specific type of immunosuppressants on rotavirus infection are still unclear. Here we prof...

journal_title：Antiviral research

authors： Yin Y,Wang Y,Dang W,Xu L,Su J,Zhou X,Wang W,Felczak K,van der Laan LJ,Pankiewicz KW,van der Eijk AA,Bijvelds M,Sprengers D,de Jonge H,Koopmans MP,Metselaar HJ,Peppelenbosch MP,Pan Q

更新日期：2016-09-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the major cause for respiratory tract disease in infants and young children. Currently, no licensed vaccine or a selective antiviral drug against RSV infections are available. Here, we describe a structure-based drug design approach that led to the synthesis of a novel series of zi...

journal_title：Antiviral research

authors： Cancellieri M,Bassetto M,Widjaja I,van Kuppeveld F,de Haan CA,Brancale A

更新日期：2015-10-01 00:00:00

abstract：:Oxymatrine (OMTR) is an anti-hepatitis drug used in China. Its mechanism of action is unknown. Recently, we found that OMTR inhibits hepatitis B virus (HBV) via down-regulating the expression of heat-stress cognate 70 (Hsc70), a host protein required for HBV DNA replication. Goal of this study was to assess the effect...

journal_title：Antiviral research

authors： Wang YP,Zhao W,Xue R,Zhou ZX,Liu F,Han YX,Ren G,Peng ZG,Cen S,Chen HS,Li YH,Jiang JD

更新日期：2011-03-01 00:00:00

abstract：:Because encapsulation of antiviral drugs in liposomes resulted generally in improved activity against retroviral replication in vivo, the antiviral effects of free-SPC3 and liposome-associated SPC3 were compared in cultured human lymphocytes infected with HIV-1. SPC3 was entrapped in various liposomal formulations, ei...

journal_title：Antiviral research

authors： de Mareuil J,Mabrouk K,Doria E,Moulard M,de Chasteigner S,Oughideni R,van Rietschoten J,Rochat H,De Waard M,Sabatier JM

更新日期：2002-06-01 00:00:00

abstract：:The antiviral activity of antisense oligonucleotides corresponding to different regions of foot-and-mouth disease virus (FMDV) genome has been assessed in BHK-21 cells. The locations of the oligonucleotides used were: (i) two regions within the internal ribosome entry site (IRES), involved in the regulation of the tra...

journal_title：Antiviral research

authors： Gutiérrez A,Rodríguez A,Pintado B,Sobrino F

更新日期：1993-09-01 00:00:00