The effect of recombinant human interferon alpha B/D compared to interferon alpha 2b on SIV infection in rhesus macaques.

abstract：:Previous studies have demonstrated that cyclopentenone prostaglandins (cyPGs) inhibit the replication of a wide variety of DNA and RNA viruses in different mammalian cell types. We investigated a new role for prostaglandin A1 (PGA1) in the inhibition of hepatitis C virus (HCV)-IRES-mediated translation. PGA1 exhibited...

journal_title：Antiviral research

authors： Tsukimoto A,Sugiyama R,Abe M,Nishitsuji H,Shimizu Y,Shimotohno K,Kawai G,Takaku H

更新日期：2015-05-01 00:00:00

abstract：:Flavivirus methyltransferase is a genetically-validated antiviral target. Crystal structures of almost all available flavivirus methyltransferases contain S-adenosyl-L-methionine (SAM), the methyl donor molecule that co-purifies with the enzymes. This raises a possibility that SAM is an integral structural component r...

journal_title：Antiviral research

authors： Noble CG,Li SH,Dong H,Chew SH,Shi PY

更新日期：2014-11-01 00:00:00

abstract：:Cell-to-cell contact is usually essential for syncytium formation by HTLV-I-infected cell lines. The present study was undertaken to determine the inhibitory effect of polyanionic compounds, dextran sulfate and heparin, on HTLV-I-induced syncytium formation, as demonstrated by the fusion of HTLV-I-infected cells with ...

journal_title：Antiviral research

authors： Ida H,Kurata A,Eguchi K,Yamashita I,Nakashima M,Sakai M,Kawabe Y,Nakamura T,Nagataki S

更新日期：1994-02-01 00:00:00

abstract：:Oligodeoxynucleotides (ODN) containing unmethylated CpG motifs are potent stimulators of the innate immune system, and are capable of aborting several infections in a non-specific manner. We here report studies of the capacity of such ODN to protect mice against infection with foot and mouth disease virus (FMDV). Susc...

journal_title：Antiviral research

authors： Kamstrup S,Frimann TH,Barfoed AM

更新日期：2006-10-01 00:00:00

abstract：:Two new influenza virus neuraminidase inhibitors (NAIs), peramivir and laninamivir, were approved in 2010 which resulted to four NAIs that were used during the 2010-2011 influenza season in Japan. This study aims to monitor the susceptibility of influenza virus isolates in 2009-2010 and 2010-2011 influenza seasons in ...

journal_title：Antiviral research

authors： Dapat C,Kondo H,Dapat IC,Baranovich T,Suzuki Y,Shobugawa Y,Saito K,Saito R,Suzuki H

更新日期：2013-09-01 00:00:00

abstract：:Desferrioxamine (DFO) is commonly used in therapy as a chelator of ferric ion in disorders of iron overload. We found that DFO inhibits human cytomegalovirus (HCMV) replication in infected cultures of human foreskin fibroblasts (HFF) at concentrations that have been achieved in humans with no significant adverse effec...

journal_title：Antiviral research

authors： Cinatl J Jr,Cinatl J,Rabenau H,Gümbel HO,Kornhuber B,Doerr HW

更新日期：1994-09-01 00:00:00

abstract：:The outbreak of severe acute respiratory syndrome (SARS) in 2003 was the first emergence of an important human pathogen in the 21st century. Responding to the epidemic provided clinicians with extensive experience in diagnosing and treating a novel respiratory viral disease. In this article, we review the experience o...

journal_title：Antiviral research

authors： Cheng VC,Chan JF,To KK,Yuen KY

更新日期：2013-11-01 00:00:00

abstract：:Sequences from the gag, pol and rev regions of the RF strain of HIV-1 (HIV-1RF) were chosen as targets for antisense phosphorothioate oligodeoxynucleotides (S-oligos). These sequences were the p18/p24 junction in gag, the active site of HIV protease in pol; a sequence from the first exon of the rev gene and S-oligodeo...

journal_title：Antiviral research

authors： Kinchington D,Galpin S,Jaroszewski JW,Ghosh K,Subasinghe C,Cohen JS

更新日期：1992-01-01 00:00:00

abstract：:Pritelivir, a helicase-primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV type 1 or 2, including acyclovir-resistant strains, were treated 72 h after infection for 7 days with pritelivir or acyclovir. Both drugs were administered ora...

journal_title：Antiviral research

authors： Quenelle DC,Birkmann A,Goldner T,Pfaff T,Zimmermann H,Bonsmann S,Collins DJ,Rice TL,Prichard MN

更新日期：2018-01-01 00:00:00

abstract：:In the present study, the protective effect of 1T1, a lambda-carrageenan extracted from the red seaweed Gigartina skottsbergii was evaluated in a murine model of herpes simplex virus type 2 (HSV-2) genital infection. Six to eight-week-old female BALB/c mice were intravaginally inoculated with a lethal dose of HSV-2 (M...

journal_title：Antiviral research

authors： Carlucci MJ,Scolaro LA,Noseda MD,Cerezo AS,Damonte EB

更新日期：2004-11-01 00:00:00

abstract：:Three SAH hydrolase inhibitors, (RS)-3-adenin-9-yl-2-hydroxypropanoic acid (isobutyl ester) [(RS)-AHPA]; (RS)-9-(2,3-dihydroxypropyl)adenine [(RS)-DHPA] and the carbocyclic analog of 3-deazaadenosine (C-c3Ado) were evaluated for their inhibitory activity against tobacco mosaic virus (TMV) and potato virus X (PVX). Usi...

journal_title：Antiviral research

authors： De Fazio G,Alba AP,Vicente M,De Clercq E

更新日期：1990-05-01 00:00:00

abstract：:Vaccines and antiviral agents are in urgent need to stop the COVID-19 pandemic. To facilitate antiviral screening against SARS-CoV-2 without requirement for high biosafety level facility, we developed a bacterial artificial chromosome (BAC)-vectored replicon of SARS-CoV-2, nCoV-SH01 strain, in which secreted Gaussia l...

journal_title：Antiviral research

authors： Zhang Y,Song W,Chen S,Yuan Z,Yi Z

更新日期：2021-01-01 00:00:00

abstract：:Cats infected with molecularly cloned FeLV-FAIDS develop an immunodeficiency syndrome characterized by persistent antigenemia, decline in circulating CD4+ T lymphocytes, and impaired T-cell-dependent immune responses and opportunistic infection. We evaluated the capacity of PMEA to inhibit the replication of FeLV-FAID...

journal_title：Antiviral research

authors： Hoover EA,Ebner JP,Zeidner NS,Mullins JI

更新日期：1991-07-01 00:00:00

abstract：:Both classical swine fever (CSF) and pseudorabies are highly contagious, economically significant diseases of swine in China. Although vaccination with the C-strain against classical swine fever virus (CSFV) is widely carried out and severe outbreaks of CSF seldom occur in China, CSF is sporadic in many pig herds and ...

journal_title：Antiviral research

authors： Tong W,Zheng H,Li GX,Gao F,Shan TL,Zhou YJ,Yu H,Jiang YF,Yu LX,Li LW,Kong N,Tong GZ,Li JC

更新日期：2020-01-01 00:00:00

abstract：:Influenza A virus has been responsible for widespread human epidemics because it is readily transmitted from humans to humans by aerosol. Recent events have highlighted the potential of influenza A virus as a bioterrorist weapon: the high virulence of the influenza A virus that infected people in Hong Kong in 1997; an...

journal_title：Antiviral research

authors： Krug RM

更新日期：2003-01-01 00:00:00

abstract：:Natural products provide a large reservoir of potentially active agents with anti-hepatitis B virus (HBV) activity. We examined the effect of the polyphenolic extract from Geranium carolinianum L. (PPGC) on HBV replication both in vitro and in vivo. In the human HBV-transfected liver cell line HepG(2) 2.2.15, PPGC eff...

journal_title：Antiviral research

authors： Li J,Huang H,Feng M,Zhou W,Shi X,Zhou P

更新日期：2008-08-01 00:00:00

abstract：:Global eradication of hepatitis C virus (HCV) infection will require an efficacious vaccine capable of eliciting protective immunity against genetically diverse HCV strains. Natural spontaneous resolution of HCV infection is associated with production of broadly-neutralizing antibodies targeting the HCV glycoproteins ...

journal_title：Antiviral research

authors： Tarr AW,Backx M,Hamed MR,Urbanowicz RA,McClure CP,Brown RJP,Ball JK

更新日期：2018-12-01 00:00:00

abstract：:Endoplasmic reticulum (ER)-resident α-glucosidases I and II sequentially trim the three terminal glucose moieties on N-linked glycans attached to nascent glycoproteins. These reactions are the first steps of N-linked glycan processing and are essential for proper folding and function of many glycoproteins. Because mos...

journal_title：Antiviral research

authors： Chang J,Block TM,Guo JT

更新日期：2013-09-01 00:00:00

abstract：:Introduction of segmented genomes into virion is an important process in viral replication of rotavirus. We previously studied the assortment of the VP7 gene segment (encoding outer capsid protein VP7) in the genetic background of simian rotavirus SA11 (G serotype 3, G3) and found the preferential selection of homolog...

journal_title：Antiviral research

authors： Okada J,Kobayashi N,Taniguchi K,Urasawa S

更新日期：1998-04-01 00:00:00

abstract：:Although highly active anti-retroviral therapy (HAART) is successful in the treatment of HIV infection, problems with toxicity, drug-resistant variants, and therapeutic failures have compromised the long-term utility of existing combination regimens. Mismatched double-stranded RNA (polyI-polyC(12)U) is an immune modul...

journal_title：Antiviral research

authors： Essey RJ,McDougall BR,Robinson WE Jr

更新日期：2001-09-01 00:00:00

abstract：:In 1989, a new type of antibody was identified, first in the sera of dromedaries and later also in all other species of the Camelidae family. These antibodies do not contain a light chain and also lack the first constant heavy domain. Today it is still unclear what the evolutionary advantage of such heavy chain-only a...

journal_title：Antiviral research

authors： Vanlandschoot P,Stortelers C,Beirnaert E,Ibañez LI,Schepens B,Depla E,Saelens X

更新日期：2011-12-01 00:00:00

abstract：:Heparan sulfate (HS) is a ubiquitous glycosaminoglycan that serves as a cellular attachment site for a number of significant human pathogens, including respiratory syncytial virus (RSV), human parainfluenza virus 3 (hPIV3), and herpes simplex virus (HSV). Decoy receptors can target pathogens by binding to the receptor...

journal_title：Antiviral research

authors： Hendricks GL,Velazquez L,Pham S,Qaisar N,Delaney JC,Viswanathan K,Albers L,Comolli JC,Shriver Z,Knipe DM,Kurt-Jones EA,Fygenson DK,Trevejo JM,Wang JP,Finberg RW

更新日期：2015-04-01 00:00:00

abstract：:Current therapies for chronic hepatitis B virus infection (CHB) - nucleos(t)ide analogue reverse transcriptase inhibitors and interferons - result in low rates of functional cure defined as sustained off-therapy seroclearance of hepatitis B surface antigen (HBsAg). One likely reason is the inability of these therapies...

journal_title：Antiviral research

authors： Gish RG,Yuen MF,Chan HL,Given BD,Lai CL,Locarnini SA,Lau JY,Wooddell CI,Schluep T,Lewis DL

更新日期：2015-09-01 00:00:00

abstract：:We have characterized the differential actions of acyclovir and penciclovir against varicella-zoster virus (VZV) in cell culture by comparing the frequency of appearance of resistant viruses followed by their characterization. Cells were infected with cell-free virus and the cultures were successively treated with inc...

journal_title：Antiviral research

authors： Ida M,Kageyama S,Sato H,Kamiyama T,Yamamura J,Kurokawa M,Morohashi M,Shiraki K

更新日期：1999-01-01 00:00:00

abstract：:Rotavirus infection has emerged as an important cause of complications in organ transplantation recipients and might play a role in the pathogenesis of inflammatory bowel disease (IBD). 6-Thioguanine (6-TG) has been widely used as an immunosuppressive drug for organ recipients and treatment of IBD in the clinic. This ...

journal_title：Antiviral research

authors： Yin Y,Chen S,Hakim MS,Wang W,Xu L,Dang W,Qu C,Verhaar AP,Su J,Fuhler GM,Peppelenbosch MP,Pan Q

更新日期：2018-08-01 00:00:00

abstract：:RNase L is a cellular endoribonuclease that is activated by 2',5'-linked oligoadenylates (2-5A), which are unique and specific ligands synthesized by a family of interferon-inducible, dsRNA-activated enzymes named oligoadenylate synthetases. In the typical antiviral pathway, activated RNase L degrades viral and cellul...

journal_title：Antiviral research

authors： Park IH,Kwon YC,Ryu WS,Ahn BY

更新日期：2014-04-01 00:00:00

abstract：:The latent reservoir of HIV-1 in resting memory CD4+ T cells serves as a major barrier to curing HIV-1 infection. Reactivation of latent HIV-1 is proposed as a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current latency reversal agents (LRAs), identification of new LRAs ...

journal_title：Antiviral research

authors： Yang H,Li X,Yang X,Lu P,Wang Y,Jiang Z,Pan H,Zhao L,Zhu Y,Khan IU,Shen Y,Lu H,Zhang T,Jiang G,Ma Z,Wu H,Zhu H

更新日期：2019-09-01 00:00:00

abstract：:A series of phosphoramidate derivatives of the anti-HIV drug AZT has been prepared as membrane soluble pro-drugs of the bio-active nucleotide forms and evaluated in vitro against HIV-1. Terminal substituted alkyl amines have a pronounced anti-HIV effect: this effect declines upon increasing the length of the methylene...

journal_title：Antiviral research

authors： Curley D,McGuigan C,Devine KG,O'Connor TJ,Jeffries DJ,Kinchington D

更新日期：1990-12-01 00:00:00

abstract：:Human cytomegalovirus infection can lead to life-threatening clinical manifestations particularly in the immunocompromised host. Current therapy options face severe limitations leading to a continued search for alternative drug candidates. Viral replication is dependent on a balanced interaction between viral and cell...

journal_title：Antiviral research

authors： Hutterer C,Wandinger SK,Wagner S,Müller R,Stamminger T,Zeitträger I,Godl K,Baumgartner R,Strobl S,Marschall M

更新日期：2013-08-01 00:00:00

abstract：:2-Furylmercury chloride (2-FMC), an organic mercury derivative, has been found to inhibit the replication of all tested human rhinovirus (HRV) serotypes belonging to the antiviral group B and a limited number of HRV serotypes belonging to the antiviral group A. The mechanism of action of 2-FMC was tested against HRV-2...

journal_title：Antiviral research

authors： Verheyden B,Andries K,Rombaut B

更新日期：2004-03-01 00:00:00