Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants.

abstract：:Cell-to-cell contact is usually essential for syncytium formation by HTLV-I-infected cell lines. The present study was undertaken to determine the inhibitory effect of polyanionic compounds, dextran sulfate and heparin, on HTLV-I-induced syncytium formation, as demonstrated by the fusion of HTLV-I-infected cells with ...

journal_title：Antiviral research

authors： Ida H,Kurata A,Eguchi K,Yamashita I,Nakashima M,Sakai M,Kawabe Y,Nakamura T,Nagataki S

更新日期：1994-02-01 00:00:00

abstract：:A novel substituted naphthalenone (TGG-II-23A) has been found that inhibits HIV-1 infection of CEM-SS cells at concentrations that are not cytotoxic. Time of addition experiments indicate that TGG-II-23A functions at a stage of the HIV-1 life cycle at or near reverse transcription. Cell free assays confirmed that TGG-...

journal_title：Antiviral research

authors： Alam M,Bechtold CM,Patick AK,Skoog MT,Gant TG,Colonno RJ,Meyers AI,Li H,Trimble J,Lin PF

更新日期：1993-10-01 00:00:00

abstract：:Dengue virus (DENV) infection is one of the most important infectious diseases in tropical and subtropical regions around the world. Previously, we performed an initial phenotypic screening of 7000 compounds using DENV type 2 (DENV2)-infected BHK-21 cells to identify small molecules which could inhibit virus replicati...

journal_title：Antiviral research

authors： Nobori H,Uemura K,Toba S,Sanaki T,Shishido T,Hall WW,Orba Y,Sawa H,Sato A

更新日期：2020-12-01 00:00:00

abstract：:Coumarins and structurally related compounds have been recently shown to inhibit replication of human immunodeficiency virus (HIV) and thus, exhibit a therapeutic potential. In this study we report that mesuol and isomesuol, two 4-phenyl coumarins, isolated from the tree Marila pluricostata, suppress HIV-1 replication...

journal_title：Antiviral research

authors： Márquez N,Sancho R,Bedoya LM,Alcamí J,López-Pérez JL,Feliciano AS,Fiebich BL,Muñoz E

更新日期：2005-06-01 00:00:00

abstract：:The 27th International Conference on Antiviral Research (ICAR) was held in Raleigh, North Carolina, USA from May 12 to 16, 2014. This article summarizes the principal invited lectures. John Drach (Elion Award) described the early days of antiviral drugs and their novel modes of action. Piet Herdewijn (Holý Award) used...

journal_title：Antiviral research

authors： Vere Hodge RA

更新日期：2014-11-01 00:00:00

abstract：:The role of herpes simplex virus type 1 (HSV-1)-encoded ribonucleotide reductase (RR) has been investigated in mice and guinea pigs using a mutant from which 90% of the large subunit of the enzyme was deleted. The RR mutant was extremely impaired in its ability to induce external vaginal lesions or to cause death in m...

journal_title：Antiviral research

authors： Idowu AD,Fraser-Smith EB,Poffenberger KL,Herman RC

更新日期：1992-02-01 00:00:00

abstract：:We isolated a ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) from a laboratory strain, AD169, and analysed the mutant. Attempts were also made to identify directly the mutated gene. The 50% inhibitory concentration (IC50) of GCV for the mutant strain was five times higher than that of the wild-type strain. T...

journal_title：Antiviral research

authors： Faizi Khan R,Mori S,Eizuru Y,Kumura Ishii K,Minamishima Y

更新日期：1998-12-01 00:00:00

abstract：:This study describes the extent of cross-resistance and interactions for selected inhibitors of human cytomegalovirus (HCMV) DNA synthesis and DNA processing. HCMV isolates resistant to the benzimidazole D-ribonucleoside viral DNA processing inhibitors TCRB and BDCRB were sensitive to BAY 38-4766, a non-nucleoside inh...

journal_title：Antiviral research

authors： Evers DL,Komazin G,Shin D,Hwang DD,Townsend LB,Drach JC

更新日期：2002-10-01 00:00:00

abstract：:Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylami...

journal_title：Antiviral research

authors： Hansen JE,Witzke NM,Nielsen C,Mathiesen LR,Teglbjaerg LS,Nielsen CM,Nielsen JO

更新日期：1990-09-01 00:00:00

abstract：:Acute lower respiratory tract infections (ALRI) caused by respiratory syncytial virus (RSV) are associated with a severe disease burden among infants and elderly patients. Treatment options are limited. While numerous drug candidates with different viral targets are under development, the utility of RSV entry inhibito...

journal_title：Antiviral research

authors： Blockus S,Sake SM,Wetzke M,Grethe C,Graalmann T,Pils M,Le Goffic R,Galloux M,Prochnow H,Rox K,Hüttel S,Rupcic Z,Wiegmann B,Dijkman R,Rameix-Welti MA,Eléouët JF,Duprex WP,Thiel V,Hansen G,Brönstrup M,Haid S,Piets

更新日期：2020-05-01 00:00:00

abstract：:The replication cycle of the human cytomegalovirus (HCMV) is characterized by the expression of immediate early (IE), early (E), and late (L) gene regions. Current antiviral strategies are directed against the viral DNA polymerase expressed during the early phase of infection. The regulation of the IE-1 and IE-2 gene ...

journal_title：Antiviral research

authors： Scholz M,Doerr HW,Cinatl J

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The combination of tenofovir disoproxil fumarate (TDF) plus emtricitabine (FTC) is used extensively to treat HIV infection and also has potent activity against hepatitis B virus (HBV) infection. The aim of this study was to assess the efficacy and tolerance of TDF + FTC in patients with chronic hepa...

journal_title：Antiviral research

authors： Si-Ahmed SN,Pradat P,Zoutendijk R,Buti M,Mallet V,Cruiziat C,Deterding K,Dumortier J,Bailly F,Esteban R,Wedemeyer H,Janssen HL,Zoulim F

更新日期：2011-10-01 00:00:00

abstract：:Cathelicidin antimicrobial peptides (human LL-37 and mouse CRAMP) are mainly virucidal to enveloped virus. However, the effects and relative mechanisms of LL-37 and CRAMP on non-enveloped virus are elusive. We herein found that CRAMP expression was significantly up-regulated post non-enveloped Enterovirus 71 (EV71) in...

journal_title：Antiviral research

authors： Yu J,Dai Y,Fu Y,Wang K,Yang Y,Li M,Xu W,Wei L

更新日期：2021-01-25 00:00:00

abstract：:Cyclosporin A (CsA) was assessed for its effect on the production of antiviral activity by human peripheral blood leukocytes (PBL). CsA markedly reduced the production of interferon-gamma (IFN-gamma) in response to stimulation with lectin mitogens, bacterial products, alloantigens, or Epstein-Barr virus (EBV)-transfor...

journal_title：Antiviral research

authors： Abb J,Abb H,Deinhardt F

更新日期：1982-12-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is an arthropod-borne alphavirus. Alphaviruses are positive strand RNA viruses that require a 5' cap structure to direct translation of the viral polyprotein and prevent degradation of the viral RNA genome by host cell nucleases. Formation of the 5' RNA cap is orchestrated by the viral protei...

journal_title：Antiviral research

authors： Feibelman KM,Fuller BP,Li L,LaBarbera DV,Geiss BJ

更新日期：2018-06-01 00:00:00

abstract：:Filoviruses, which include Ebola virus (EBOV) and Marburg virus, are negative-sense RNA viruses associated with sporadic outbreaks of severe viral hemorrhagic fever characterized by uncontrolled virus replication. The extreme virulence and emerging nature of these zoonotic pathogens make them a significant threat to h...

journal_title：Antiviral research

authors： Basler CF,Krogan NJ,Leung DW,Amarasinghe GK

更新日期：2019-02-01 00:00:00

abstract：:A synthetic muramyldipeptide (MDP) and two analogues, B30-MDP and MDP-Lys(L18), augmented serum interferon (IFN) production in mice by the inducers lipopolysaccharide (LPS) and polyinosinic acid:polycytidylic acid (poly I:C), and also augmented immune IFN production induced by purified protein derivative (PPD) in myco...

journal_title：Antiviral research

authors： Ikeda S,Matsuda Y,Nishimura C

更新日期：1985-12-01 00:00:00

abstract：:Previous studies have demonstrated that cyclopentenone prostaglandins (cyPGs) inhibit the replication of a wide variety of DNA and RNA viruses in different mammalian cell types. We investigated a new role for prostaglandin A1 (PGA1) in the inhibition of hepatitis C virus (HCV)-IRES-mediated translation. PGA1 exhibited...

journal_title：Antiviral research

authors： Tsukimoto A,Sugiyama R,Abe M,Nishitsuji H,Shimizu Y,Shimotohno K,Kawai G,Takaku H

更新日期：2015-05-01 00:00:00

abstract：:The ability to rescue an infectious, recombinant, negative-stranded, RNA virus from a complementary DNA (cDNA) clone, has led to new opportunities for measuring viral replication from a viral expressed reporter gene. In this study, the enhanced green fluorescent protein (EGFP) gene was inserted into the human parainfl...

journal_title：Antiviral research

authors： Roth JP,Li JK,Smee DF,Morrey JD,Barnard DL

更新日期：2009-04-01 00:00:00

abstract：:On September 22, 2008, a physician on Prince of Wales Island, Alaska, notified the Alaska Department of Health and Social Services (ADHSS) of an unusually high number of adult patients with recently diagnosed pneumonia (n = 10), including three persons who required hospitalization and one who died. ADHSS and CDC condu...

journal_title：Antiviral research

authors： Kumaki Y,Woolcott JD,Roth JP,Mclean TZ,Smee DF,Barnard DL,Valiaeva N,Beadle JR,Hostetler KY

更新日期：2018-10-01 00:00:00

abstract：:Development of anti-dengue therapy represents an urgent un-met medical need. Towards antiviral therapy, recent advances in crystal structures of DENV enzymes have led to the possibility of structure-based rational design of inhibitors for anti-dengue therapy. These include (i) the structure of the 'active' form of the...

journal_title：Antiviral research

authors： Noble CG,Shi PY

更新日期：2012-11-01 00:00:00

abstract：:The antiviral effect of foscarnet (PFA) on the replication of rotavirus, a member of the Reoviridae, was studied. The pyrophosphate analogue is an effective inhibitor of several viral polymerases acting on the enzyme pyrophosphate binding site. Replication of rotavirus in MA104 cells using different u.o.i. was inhibit...

journal_title：Antiviral research

authors： Ríos M,Muñoz M,Spencer E

更新日期：1995-05-01 00:00:00

abstract：:In the absence of antiviral treatment, chronic hepatitis C virus (HCV) infection is a liver disease characterized by the development of necroinflammatory changes and progressive liver fibrosis, leading to cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). The approval of ribavirin in combination th...

journal_title：Antiviral research

authors： Medina J,García-Buey L,Moreno-Monteagudo JA,Trapero-Marugán M,Moreno-Otero R

更新日期：2003-10-01 00:00:00

abstract：:Antiviral compounds were evaluated for efficacy against yellow fever virus (YFV) in a hamster model of YFV-induced liver disease. Challenge with a 10(2) 50% cell culture infectious doses of YFV resulted in a 50-80% mortality rate in female hamsters. Virus was detected by quantitative real-time RT-PCR (QRT-PCR) in live...

journal_title：Antiviral research

authors： Julander JG,Morrey JD,Blatt LM,Shafer K,Sidwell RW

更新日期：2007-02-01 00:00:00

abstract：:Twenty-five years after the discovery of the therapeutic activity of azidothymidine (AZT), the first antiretroviral drug used in the clinic, infection with the human immunodeficiency virus (HIV) has become, at least in the industrialized world, a manageable chronic disease with a significant improvement in life expect...

journal_title：Antiviral research

authors： Esté JA,Cihlar T

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Interferon-alpha treatment has been the treatment of choice for chronic hepatitis with unpredictable results. Recently, Lamivudine has been licensed for use against HBV infection with good results. Unfortunately, recurrence of viremia after lamivudine withdrawal is common and prolonged treatment can...

journal_title：Antiviral research

authors： Andreone P,Fiorino S,Cursaro C,Gramenzi A,Margotti M,Di Giammarino L,Biselli M,Miniero R,Gasbarrini G,Bernardi M

更新日期：2001-02-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HAND) remain prevalent even with widespread use of combination antiretroviral therapy (ART), suggesting a potential role for co-morbidities in neurologic decline. Indeed, it is well established that ART drugs, particularly HIV protease inhibitors, can induce hyperlipidemia, lip...

journal_title：Antiviral research

authors： Gupta S,Knight AG,Losso BY,Ingram DK,Keller JN,Bruce-Keller AJ

更新日期：2012-07-01 00:00:00

abstract：:(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, HPMPC, and two HPMPC-related nucleoside analogs, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, HPMPA, and (2-phosphonylmethoxyethyl)guanine, PMEG, were evaluated for their antiviral activities against guinea pig cytomegalovirus (GPCMV) infection in guinea pig ...

journal_title：Antiviral research

authors： Li SB,Yang ZH,Feng JS,Fong CK,Lucia HL,Hsiung GD

更新日期：1990-05-01 00:00:00

abstract：:The K70E mutation in HIV-1 reverse transcriptase was observed in 10% of virologic non-responders of the abacavir/lamivudine/tenofovir arm of ESS30009, alone, or in mixtures with K65R by population sequencing. Clonal analysis of six ESS30009 K70E isolates failed to identify double mutants carrying K65R+K70E. Site-direc...

journal_title：Antiviral research

authors： Kagan RM,Lee TS,Ross L,Lloyd RM Jr,Lewinski MA,Potts SJ

更新日期：2007-09-01 00:00:00

abstract：:Argentine hemorrhagic fever is a systemic viral disease caused by Junin virus, with a mortality of 15-30% in untreated individuals. Current specific therapy is highly effective in reducing mortality, and consists of the early administration of immune plasma in defined doses of specific neutralizing antibodies per kg o...

journal_title：Antiviral research

authors： Enria DA,Maiztegui JI

更新日期：1994-01-01 00:00:00