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Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.

Abstract：

:Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N"-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Hansen JE,Witzke NM,Nielsen C,Mathiesen LR,Teglbjaerg LS,Nielsen CM,Nielsen JO

doi

10.1016/0166-3542(90)90031-2

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

149-59

issue

3

eissn

0166-3542

issn

1872-9096

pii

0166-3542(90)90031-2

journal_volume

14

pub_type

杂志文章

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