Perspectives on antiviral drug development.


:The 21st International Conference on Antiviral Research provided novel insights and approaches to drug discovery across a wide array of virologic fields. Topics ranged from the chemical synthesis of new compounds against the human immunodeficiency virus (HIV) to the long-term use of established drugs against influenza. A session on novel targets for HIV therapy focused on the importance of Apobec3G, LEDGF/p75 and other cellular factors as innovative ways to control infection. New targets for hepatitis B and C viruses were surveyed. There were also discussions as to how the development of new antiviral compounds might lead to novel mechanisms of drug resistance by HIV, herpesviruses and hepatitis viruses. These covered such issues as transmission dynamics, viral fitness, the acquisition of differential resistance patterns depending on viral subtype, and clinical outcomes. Drug efficacy, toxicity, patient adherence, treatment interruption and the importance of generic drugs in resource-poor settings were also extensively discussed. These topics will all play a pivotal role in drug development and the management of viral infections in the years to come.


Antiviral Res


Antiviral research


Wainberg MA




Has Abstract


2009-01-01 00:00:00














  • The effect of HSV multiplication rate on antiviral drug efficacy in vitro.

    abstract::HSV-1 multiplication rates have been shown to vary in different tissues and the rate of multiplication may correlate with susceptibility to antiviral chemotherapy. Herpetic stromal keratitis is a necrotizing condition refractive to antiviral therapy and this lack of antiviral efficacy in stromal disease may be the res...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Upadhyay JM,Hill JM,Jemison M,Helmy MF,Kaufman HE

    更新日期:1991-01-01 00:00:00

  • Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14 days of therapy.

    abstract:BACKGROUND:Cyclophilin inhibitors have shown activity against a variety of viruses, including HCV. NIM811, a novel, non-immunosuppressive cyclophilin inhibitor was studied in ascending doses in a randomized, double-blind, placebo-controlled 14-day trial in genotype 1 HCV patients. Doses of 10 up to 600 mg were given or...

    journal_title:Antiviral research

    pub_type: 杂志文章,随机对照试验


    authors: Lawitz E,Godofsky E,Rouzier R,Marbury T,Nguyen T,Ke J,Huang M,Praestgaard J,Serra D,Evans TG

    更新日期:2011-03-01 00:00:00

  • In vitro and in vivo anti-hepatitis B virus activities of a plant extract from Geranium carolinianum L.

    abstract::Natural products provide a large reservoir of potentially active agents with anti-hepatitis B virus (HBV) activity. We examined the effect of the polyphenolic extract from Geranium carolinianum L. (PPGC) on HBV replication both in vitro and in vivo. In the human HBV-transfected liver cell line HepG(2) 2.2.15, PPGC eff...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Li J,Huang H,Feng M,Zhou W,Shi X,Zhou P

    更新日期:2008-08-01 00:00:00

  • 6-Thioguanine inhibits rotavirus replication through suppression of Rac1 GDP/GTP cycling.

    abstract::Rotavirus infection has emerged as an important cause of complications in organ transplantation recipients and might play a role in the pathogenesis of inflammatory bowel disease (IBD). 6-Thioguanine (6-TG) has been widely used as an immunosuppressive drug for organ recipients and treatment of IBD in the clinic. This ...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Yin Y,Chen S,Hakim MS,Wang W,Xu L,Dang W,Qu C,Verhaar AP,Su J,Fuhler GM,Peppelenbosch MP,Pan Q

    更新日期:2018-08-01 00:00:00

  • Role of trehalose dimycolate-induced interferon-alpha/beta in the restriction of encephalomyocarditis virus growth in vivo and in peritoneal macrophage cultures.

    abstract::Preventive intraperitoneal trehalose dimycolate (TDM) treatment of mice, inoculated with encephalomyocarditis (EMC) virus by the same route, caused restriction of virus growth in the peritoneum, which was correlated to IFN production in peritoneal fluids prior to infection. Peritoneal macrophages from TDM-treated mice...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Guillemard E,Geniteau-Legendre M,Kergot R,Lemaire G,Petit JF,Labarre C,Quero AM

    更新日期:1995-10-01 00:00:00

  • Citrate-mediated disaggregation of rotavirus particles in RotaTeq vaccine.

    abstract::For the routine manufacture of live virus vaccines, virus is diluted into a formulation buffer to stabilize it for long-term storage, and to facilitate vaccine administration. The characteristics of this buffer are dependent on the storage temperature of the vaccine, as well as the desired characteristics of the produ...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Peterson SE,Wang S,Ranheim T,Owen KE

    更新日期:2006-02-01 00:00:00

  • Antiviral effect of cyclopentenone prostaglandins on vesicular stomatitis virus replication.

    abstract::Prostaglandins are potentially useful antiviral agents, however their mechanism of action is unclear. Recent evidence suggests that RNA transcription of vesicular stomatitis virus (VSV) is inhibited by prostaglandins (Bader and Ankel, J. Gen. Virol. 71, 2823-2832, 1990). Prostaglandins are known to have multiple effec...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Parker J,Ahrens PB,Ankel H

    更新日期:1995-01-01 00:00:00

  • Inhibition of Japanese encephalitis virus entry into the cells by the envelope glycoprotein domain III (EDIII) and the loop3 peptide derived from EDIII.

    abstract::Japanese encephalitis virus (JEV) infection is a major cause of acute viral encephalitis both in humans and animals. The domain III of virus envelope protein (EDIII) plays important roles in interacting with host cell receptors to facilitate virus entry. In this study, recombinant JEV EDIII was expressed and purified....

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Li C,Zhang LY,Sun MX,Li PP,Huang L,Wei JC,Yao YL,Isahg H,Chen PY,Mao X

    更新日期:2012-05-01 00:00:00

  • Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway.

    abstract::Coumarins and structurally related compounds have been recently shown to inhibit replication of human immunodeficiency virus (HIV) and thus, exhibit a therapeutic potential. In this study we report that mesuol and isomesuol, two 4-phenyl coumarins, isolated from the tree Marila pluricostata, suppress HIV-1 replication...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Márquez N,Sancho R,Bedoya LM,Alcamí J,López-Pérez JL,Feliciano AS,Fiebich BL,Muñoz E

    更新日期:2005-06-01 00:00:00

  • Dead-end complexes contribute to the synergistic inhibition of HIV-1 RT by the combination of rilpivirine, emtricitabine, and tenofovir.

    abstract::The single tablet regimen of the nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) tenofovir disoproxil fumarate (TDF), emtricitabine (FTC), and the non-nucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) is approved for the treatment of HIV-1 infection in treatment-naïve adults. Previous...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Kulkarni R,Feng JY,Miller MD,White KL

    更新日期:2014-01-01 00:00:00

  • Modeling HCV cure after an ultra-short duration of therapy with direct acting agents.

    abstract:BACKGROUND:Cases of sustained-virological response (SVR or cure) after an ultra-short duration (≤27 days) of direct-acting antiviral (DAA)-based therapy, despite HCV being detected at end of treatment (EOT), have been reported. Established HCV mathematical models that predict the treatment duration required to achieve ...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Goyal A,Lurie Y,Meissner EG,Major M,Sansone N,Uprichard SL,Cotler SJ,Dahari H

    更新日期:2017-08-01 00:00:00

  • S-acyl-2-thioethyl (SATE) pronucleotides are potent inhibitors of HIV-1 replication in T-lymphoid cells cross-resistant to deoxycytidine and thymidine analogs.

    abstract::The biological evaluation of mononucleotide prodrugs (pronucleotides) of various nucleoside reverse transcriptase inhibitors (NRTIs) such as zidovudine (AZT), zalcitabine (ddC) and lamivudine (3TC) was reported in human T-lymphoid MOLT-4/8 cells which were grown continuously for more than 1 year in a medium containing...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Gröschel B,Cinatl J,Périgaud C,Gosselin G,Imbach JL,Doerr HW,Cinatl J Jr

    更新日期:2002-02-01 00:00:00

  • Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017-2018.

    abstract::The global analysis of neuraminidase inhibitor (NAI) susceptibility of influenza viruses has been conducted since the 2012-13 period. In 2018 a novel cap-dependent endonuclease inhibitor, baloxavir, that targets polymerase acidic subunit (PA) was approved for the treatment of influenza virus infection in Japan and the...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Takashita E,Daniels RS,Fujisaki S,Gregory V,Gubareva LV,Huang W,Hurt AC,Lackenby A,Nguyen HT,Pereyaslov D,Roe M,Samaan M,Subbarao K,Tse H,Wang D,Yen HL,Zhang W,Meijer A

    更新日期:2020-03-01 00:00:00

  • Effect of interferon on herpes simplex virus replication in murine macrophage-like cell lines.

    abstract::The effect of interferon on the replication of herpes simplex virus types 1 and 2 was studied in two murine macrophage-like cell lines which differ in their ability to synthesize interferon. Higher titers of herpes simplex virus type 1 occurred in PU5-1.8 cell cultures where interferon was not produced than in J774A.1...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Salo RJ,Ortega AP

    更新日期:1986-05-01 00:00:00

  • Mycophenolic acid potently inhibits rotavirus infection with a high barrier to resistance development.

    abstract::Rotavirus infection has emerged as an important cause of complications in organ transplantation recipients. Immunosuppressants used to prevent alloreactivity can also interfere with virus infection, but the direct effects of the specific type of immunosuppressants on rotavirus infection are still unclear. Here we prof...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Yin Y,Wang Y,Dang W,Xu L,Su J,Zhou X,Wang W,Felczak K,van der Laan LJ,Pankiewicz KW,van der Eijk AA,Bijvelds M,Sprengers D,de Jonge H,Koopmans MP,Metselaar HJ,Peppelenbosch MP,Pan Q

    更新日期:2016-09-01 00:00:00

  • Inhibition of the reverse transcriptase from HIV by 3'-azido-3'-deoxythymidine triphosphate and its threo analogue.

    abstract::3'-Azido-3'-deoxythymidine triphosphate (erythro) and its threo isomer were synthesized and investigated for their inhibition of HIV reverse transcriptase from virus isolate U 937/HTLV-III. The erythro isomer was a competitive inhibitor of the reaction directed by (rA)n(dT)12-18 and the Ki value was 0.0022 microM. The...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Vrang L,Bazin H,Remaud G,Chattopadhyaya J,Oberg B

    更新日期:1987-03-01 00:00:00

  • Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles.

    abstract::Zika virus (ZIKV) is a mosquito-borne flavivirus that mostly causes asymptomatic infections or mild disease characterized by low-grade fever, rash, conjunctivitis, and malaise. However, the recent massive ZIKV epidemics in the Americas have also linked ZIKV infection to fetal malformations like microcephaly and Guilla...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Albulescu IC,Kovacikova K,Tas A,Snijder EJ,van Hemert MJ

    更新日期:2017-07-01 00:00:00

  • In silico study supports the efficacy of a reduced dose regimen for stavudine.

    abstract::Stavudine (d4T) is used extensively as part of HAART in resource poor settings, despite its toxicities. The revised WHO guidelines specify replacement of d4T with less toxic but more expensive drugs when feasible, and that d4T doses be standardized to 30 mg twice daily (bid) (irrespective of body-weight), from the app...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Hurwitz SJ,Schinazi RF

    更新日期:2011-11-01 00:00:00

  • Interferon plus Chinese herbs are associated with higher sustained virological response than interferon alone in chronic Hepatitis C: a meta-analysis of randomised trials.

    abstract:BACKGROUND/AIMS:Traditional Chinese herbal therapies are widely used for the treatment of chronic hepatitis C (CHC) in Asia. The aim of this study was to perform a meta-analysis of randomised controlled trials (RCTs) comparing interferon therapies with Chinese herbal therapies and/or interferon plus Chinese herb therap...

    journal_title:Antiviral research

    pub_type: 杂志文章,meta分析


    authors: Zhao S,Liu E,Wei K,Lu S,Chu Y,Li Y,Wang Y,Huang B,Chen Y,Yang P

    更新日期:2011-02-01 00:00:00

  • Genetic analysis of a ganciclovir-resistant human cytomegalovirus mutant.

    abstract::We isolated a ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) from a laboratory strain, AD169, and analysed the mutant. Attempts were also made to identify directly the mutated gene. The 50% inhibitory concentration (IC50) of GCV for the mutant strain was five times higher than that of the wild-type strain. T...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Faizi Khan R,Mori S,Eizuru Y,Kumura Ishii K,Minamishima Y

    更新日期:1998-12-01 00:00:00

  • Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation.

    abstract::The influenza A virus (IAV) NS1 protein is one of the major regulators of pathogenicity, being able to suppress innate immune response and host protein synthesis. In this study we identified the human micro RNA hsa-miR-1307-3p as a novel potent suppressor of NS1 expression and influenza virus replication. Transcriptom...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Bavagnoli L,Campanini G,Forte M,Ceccotti G,Percivalle E,Bione S,Lisa A,Baldanti F,Maga G

    更新日期:2019-11-01 00:00:00

  • A comparison of gag, pol and rev antisense oligodeoxynucleotides as inhibitors of HIV-1.

    abstract::Sequences from the gag, pol and rev regions of the RF strain of HIV-1 (HIV-1RF) were chosen as targets for antisense phosphorothioate oligodeoxynucleotides (S-oligos). These sequences were the p18/p24 junction in gag, the active site of HIV protease in pol; a sequence from the first exon of the rev gene and S-oligodeo...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Kinchington D,Galpin S,Jaroszewski JW,Ghosh K,Subasinghe C,Cohen JS

    更新日期:1992-01-01 00:00:00

  • Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine.

    abstract::Venezuelan equine encephalitis virus (VEEV) may cause encephalitis in humans, for which no FDA-approved antiviral treatment is available. Carbocyclic cytosine (carbodine) has broad-spectrum activity but toxicity has limited its utility. It was anticipated that one of the enantiomers of carbodine would show enhanced ac...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Julander JG,Bowen RA,Rao JR,Day C,Shafer K,Smee DF,Morrey JD,Chu CK

    更新日期:2008-12-01 00:00:00

  • Maraviroc Clinical Test (MCT) as an alternative tool to decide CCR5-antagonists prescription in naïve HIV-infected patients.

    abstract::Our aim was to analyze the virological response to a combined antiretroviral therapy started after Maraviroc Clinical Test (MCT) in naïve HIV-infected patients. Forty-one patients were exposed to MCT, based on an 8-day MVC monotherapy. If undetectability or a viral load reduction >1 log10 HIV-RNA copies/ml was achieve...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Genebat M,de Pablo-Bernal RS,Pulido I,Jiménez-Mejías ME,Martínez O,Pacheco YM,Raffi-El-Idrissi Benhia M,Abad MA,Ruiz-Mateos E,Leal M

    更新日期:2015-09-01 00:00:00

  • Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo.

    abstract::We have investigated the inhibitory effect of trans-cinnamaldehyde (CA), one of the principal constituents of essential oil derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo. When 1-h drug treatment was initiated at various times post-infection (p.i.) in Madin-Darby canine kid...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Hayashi K,Imanishi N,Kashiwayama Y,Kawano A,Terasawa K,Shimada Y,Ochiai H

    更新日期:2007-04-01 00:00:00

  • Synergistic inhibition of HIV-1 infection by combinations of soluble polyanions with other potential microbicides.

    abstract::Several polyanionic compounds with potential for use as topically applied microbicides to prevent HIV-1 sexual transmission, such as PRO 2000, are currently in phase III clinical efficacy trials. Microbicidal formulations may well comprise combinations of inhibitors to increase potency, reduce dose and minimize proble...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Gantlett KE,Weber JN,Sattentau QJ

    更新日期:2007-09-01 00:00:00

  • Mechanism of inhibitory effect of dextran sulfate and heparin on human T-cell lymphotropic virus type I (HTLV-I)-induced syncytium formation in vitro: role of cell-to-cell contact.

    abstract::Cell-to-cell contact is usually essential for syncytium formation by HTLV-I-infected cell lines. The present study was undertaken to determine the inhibitory effect of polyanionic compounds, dextran sulfate and heparin, on HTLV-I-induced syncytium formation, as demonstrated by the fusion of HTLV-I-infected cells with ...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Ida H,Kurata A,Eguchi K,Yamashita I,Nakashima M,Sakai M,Kawabe Y,Nakamura T,Nagataki S

    更新日期:1994-02-01 00:00:00

  • Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells.

    abstract::Infections by dengue virus (DENV) are increasing worldwide, with an urgent need for effective anti-DENV agents. We recently identified N-(4-hydroxyphenyl) retinamide (4-HPR), an anti-DENV agent effective against all 4 serotypes of DENV in cell culture, and in a lethal mouse model for DENV infection (Fraser et al., 201...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Fraser JE,Wang C,Chan KW,Vasudevan SG,Jans DA

    更新日期:2016-06-01 00:00:00

  • Isolation, purification, and partial characterization of prunellin, an anti-HIV component from aqueous extracts of Prunella vulgaris.

    abstract::Prunellin, an anti-HIV active compound, was isolated from aqueous extracts of the Chinese medicinal herb, Prunella vulgaris, and purified to chromatographic homogeneity. Infrared and NMR spectroscopy identified prunellin as a polysaccharide. Elemental analyses, precipitation with calcium(II), barium(II), or 9-aminoacr...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Tabba HD,Chang RS,Smith KM

    更新日期:1989-06-01 00:00:00

  • Transient inhibition of foot-and-mouth disease virus infection of BHK-21 cells by antisense oligonucleotides directed against the second functional initiator AUG.

    abstract::The antiviral activity of antisense oligonucleotides corresponding to different regions of foot-and-mouth disease virus (FMDV) genome has been assessed in BHK-21 cells. The locations of the oligonucleotides used were: (i) two regions within the internal ribosome entry site (IRES), involved in the regulation of the tra...

    journal_title:Antiviral research

    pub_type: 杂志文章


    authors: Gutiérrez A,Rodríguez A,Pintado B,Sobrino F

    更新日期:1993-09-01 00:00:00