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Chemotherapy of Aujeszky's disease (pseudorabies) in the mouse by means of nucleoside analogues: bromovinyldeoxyuridine, acyclovir, and dihydroxypropoxymethylguanine.

Abstract：

:Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus titre and slight prolongation of survival. Acyclovir (ACV) and dihydroxypropoxymethylguanine (DHPG) were both less active than BVDU when tested against the virus in BHK cells, yet DHPG therapy was extremely effective in mice; it reduced virus titres markedly and resulted in the long-term survival of mice given a potentially lethal infection. When ACV and DHPG were tested in vitro using murine rather than hamster cells, these compounds, especially DHPG, were shown to be much more active against PRV.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Field HJ

doi

10.1016/0166-3542(85)90048-8

subject

Has Abstract

pub_date

1985-06-01 00:00:00

pages

157-68

issue

3

eissn

0166-3542

issn

1872-9096

pii

0166-3542(85)90048-8

journal_volume

5

pub_type

杂志文章

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