Abstract:
:Resveratrol (3,5,4'-trihydroxystilbene) is a natural component of certain foods, such as grapes, that has been shown to have anti-herpes simplex virus (HSV) activity in vitro. To determine if it is active in vivo, the abraded epidermis of SKH1 mice were infected with HSV-1 and topically treated with 12.5 or 25% resveratrol cream or cream only. Initial studies demonstrated that: (1). 25% resveratrol cream topically applied two, three, or five times a day effectively suppressed lesion development whereas 12.5% resveratrol cream effectively suppressed lesion formation when applied five times a day starting 1h after infection; (2). when treatment was begun 1, 6, or 12h after infection, both 12.5 and 25% resveratrol were effective at 1 and 6h after infection, but not if applied 12h after infection. Comparative studies between resveratrol cream, 10% docosanol cream (Abreva) and 5% acyclovir ointment (Zovirax) were also carried out. When treatment was begun 1h after infection and repeated every 3h five times a day for 5 days, 12.5 and 25% resveratrol significantly (P=0.0001) inhibited the development of HSV-1 induced skin lesions. Acyclovir was as effective (P=0.0001) as resveratrol. Animals that were topically treated with docosanol were not protected and developed lesions in a manner indistinguishable from cream only controls. These studies were repeated with an HSV-1 acyclovir-resistant virus. As before, 12.5 and 25% resveratrol cream effectively suppressed lesion formation. The skin of resveratrol-treated animals showed no apparent dermal toxicity such as erythema, scaling, crusting, lichenification, or excoriation. These studies demonstrate that topically applied resveratrol inhibits HSV lesion formation in the skin of mice.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Docherty JJ,Smith JS,Fu MM,Stoner T,Booth Tdoi
10.1016/j.antiviral.2003.07.001subject
Has Abstractpub_date
2004-01-01 00:00:00pages
19-26issue
1eissn
0166-3542issn
1872-9096pii
S0166354203001785journal_volume
61pub_type
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journal_title:Antiviral research
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:1983-09-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2004.12.007
更新日期:2005-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0166-3542(85)90027-0
更新日期:1985-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.antiviral.2019.104554
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pub_type: 杂志文章
doi:10.1016/j.antiviral.2008.06.011
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1997-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1993-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章
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abstract::Despite an urgent medical need, a broadly effective anti-viral therapy for the treatment of infections with hepatitis C viruses (HCVs) has yet to be developed. One of the approaches to anti-HCV drug discovery is the design and development of specific small molecule drugs to inhibit the proteolytic processing of the HC...
journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:
更新日期:1999-02-01 00:00:00
abstract::Foot and mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. Previously, we found that the epitope peptide EP141-160 displayed on virus-like particles (VLP) for use as a vaccine showed high immunoreactivity and conferred partially effective protection to animals. In this study, we first ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2016.08.020
更新日期:2016-10-01 00:00:00