当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > The ReFRAME library as a comprehensive drug repurposing library to identify mammarenavirus inhibitors.

The ReFRAME library as a comprehensive drug repurposing library to identify mammarenavirus inhibitors.

Abstract：

:Several mammarenaviruses, chiefly Lassa virus (LASV) in Western Africa and Junín virus (JUNV) in the Argentine Pampas, cause severe disease in humans and pose important public health problems in their endemic regions. Moreover, mounting evidence indicates that the worldwide-distributed mammarenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen of clinical significance. The lack of licensed mammarenavirus vaccines and partial efficacy of current anti-mammarenavirus therapy limited to an off-label use of the nucleoside analog ribavirin underscore an unmet need for novel therapeutics to combat human pathogenic mammarenavirus infections. This task can be facilitated by the implementation of "drug repurposing" strategies to reduce the time and resources required to advance identified antiviral drug candidates into the clinic. We screened a drug repurposing library of 11,968 compounds (Repurposing, Focused Rescue and Accelerated Medchem [ReFRAME]) and identified several potent inhibitors of LCMV multiplication that had also strong anti-viral activity against LASV and JUNV. Our findings indicate that enzymes of the rate-limiting steps of pyrimidine and purine biosynthesis, the pro-viral MCL1 apoptosis regulator, BCL2 family member protein and the mitochondrial electron transport complex III, play critical roles in the completion of the mammarenavirus life cycle, suggesting they represent potential druggable targets to counter human pathogenic mammarenavirus infections.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Kim YJ,Cubitt B,Chen E,Hull MV,Chatterjee AK,Cai Y,Kuhn JH,de la Torre JC

doi

10.1016/j.antiviral.2019.104558

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

104558

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(19)30244-X

journal_volume

169

pub_type

杂志文章

相关文献

ANTIVIRAL RESEARCH文献大全
  • Zika, dengue and yellow fever viruses induce differential anti-viral immune responses in human monocytic and first trimester trophoblast cells.

    abstract：:Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neonatal birth defects, but the causative mechanism is incompletely understood. ZIKV shares sequence homology and early clinical manifestations with yellow fever virus (YFV) and dengue virus (DENV) and are all transmitted in urban cycles by the sa...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2018.01.003

    authors： Luo H,Winkelmann ER,Fernandez-Salas I,Li L,Mayer SV,Danis-Lozano R,Sanchez-Casas RM,Vasilakis N,Tesh R,Barrett AD,Weaver SC,Wang T

    更新日期：2018-03-01 00:00:00

  • Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation.

    abstract：:The influenza A virus (IAV) NS1 protein is one of the major regulators of pathogenicity, being able to suppress innate immune response and host protein synthesis. In this study we identified the human micro RNA hsa-miR-1307-3p as a novel potent suppressor of NS1 expression and influenza virus replication. Transcriptom...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104593

    authors： Bavagnoli L,Campanini G,Forte M,Ceccotti G,Percivalle E,Bione S,Lisa A,Baldanti F,Maga G

    更新日期：2019-11-01 00:00:00

  • A novel isothiocyanate derivative inhibits HIV-1 gene expression and replication by modulating the nuclear matrix associated protein SMAR1.

    abstract：:The essential role of SMAR1 in HIV-1 transcription and LTR driven gene expression suggests SMAR1 as an HIV dependency factor (HDF) and a potential anti-HIV therapeutic target. Here, we report for the first time, anti-HIV activity of 8 novel isothiocyanate (ITC) derivatives that differentially stabilise SMAR1. Out of 8...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104648

    authors： Trivedi J,Alam A,Joshi S,Kumar TP,Chippala V,Mainkar PS,Chandrasekhar S,Chattopadhyay S,Mitra D

    更新日期：2020-01-01 00:00:00

  • High-throughput screening for negative-stranded hemorrhagic fever viruses using reverse genetics.

    abstract：:Viral hemorrhagic fevers (VHFs) cause thousands of fatalities every year, but the treatment options for their management remain very limited. In particular, the development of therapeutic interventions is restricted by the lack of commercial viability of drugs targeting individual VHF agents. This makes approaches lik...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2019.104569

    authors： Wendt L,Bostedt L,Hoenen T,Groseth A

    更新日期：2019-10-01 00:00:00

  • Use of preconditioned human phagocytes for extracorporeal adsorption of viruses.

    abstract：:Conventional treatment of severe viral disease is limited by the narrow choice as well as the often-significant side effects or lack of clear efficacy of antiviral chemotherapy. At the same time, however, it is known that a reduction in viral load leads to significant clinical improvement in a number of important vira...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2010.05.007

    authors： Oberender F,Oberender H,Altrichter J,Reisinger EC,Mitzner SR

    更新日期：2010-08-01 00:00:00

  • A new contained human immunodeficiency virus type 1 host cell system for evaluation of antiviral activities of interferons and other agents in vitro.

    abstract：:HIV-host infection systems in vitro are important in the pre-clinical assessment of anti-retroviral drug activity. The present report describes the development of a new HIV-host model comprised of an epithelial cell line of HeLa lineage (HeLa-1), transfected with expression vectors bearing tat and rev (TART) genes of ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(99)00014-5

    authors： Moussazadeh M,Hua J,Sidhu MK,Zhao XX,Fitzgibbon JE,Liao MJ,Rashidbaigi A

    更新日期：1999-07-01 00:00:00

  • Protection of a novel epitope-RNA VLP double-effective VLP vaccine for foot-and-mouth disease.

    abstract：:Foot and mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. Previously, we found that the epitope peptide EP141-160 displayed on virus-like particles (VLP) for use as a vaccine showed high immunoreactivity and conferred partially effective protection to animals. In this study, we first ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2016.08.020

    authors： Dong YM,Cai JC,Chen HT,Chen L

    更新日期：2016-10-01 00:00:00

  • Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro.

    abstract：:The internal ribosome entry site (IRES) of hepatitis C virus (HCV) which governs the initiation of protein synthesis from viral RNA represents an ideal target for antisense approaches. Using an original bicistronic plasmid, we first established that sequence and translational activity of HCV IRESs cloned from six pati...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2008.06.011

    authors： Alotte C,Martin A,Caldarelli SA,Di Giorgio A,Condom R,Zoulim F,Durantel D,Hantz O

    更新日期：2008-12-01 00:00:00

  • In vitro inhibition of human cytomegalovirus replication by desferrioxamine.

    abstract：:Desferrioxamine (DFO) is commonly used in therapy as a chelator of ferric ion in disorders of iron overload. We found that DFO inhibits human cytomegalovirus (HCMV) replication in infected cultures of human foreskin fibroblasts (HFF) at concentrations that have been achieved in humans with no significant adverse effec...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(94)90095-7

    authors： Cinatl J Jr,Cinatl J,Rabenau H,Gümbel HO,Kornhuber B,Doerr HW

    更新日期：1994-09-01 00:00:00

  • Natural killer cell activity and function in chronic HCV-infected patients during peg interferon and ribavirin: early effects of active substance use.

    abstract：:In Western countries, chronic hepatitis C virus (HCV)-infection mostly affects former and active substance users. The effect of active substance use on interferon (IFN)-responsiveness and therapy efficacy is not well understood. In this study, we compared natural killer (NK) cell activity and function in healthy contr...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2012.12.025

    authors： Hotho DM,Kreefft K,Groothuismink ZM,Janssen HL,de Knegt RJ,Boonstra A

    更新日期：2013-03-01 00:00:00

  • Everolimus delayed and suppressed cytomegalovirus DNA synthesis, spread of the infection, and alleviated cytomegalovirus infection.

    abstract：:Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) and reduces the risk of cytomegalovirus (CMV) infection in transplant recipients. Everolimus inhibits mTOR complex 1, which regulates factors involved in several crucial cellular functions and is required for CMV replication. However, it is not clear h...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2018.12.004

    authors： Tan L,Sato N,Shiraki A,Yanagita M,Yoshida Y,Takemura Y,Shiraki K

    更新日期：2019-02-01 00:00:00

  • Protective efficacy of Fc targeting conserved influenza virus M2e antigen expressed by Lactobacillus plantarum.

    abstract：:The influenza A (H1N1) virus is a highly contagious acute respiratory disease affecting pigs and humans. This disease causes severe economic loss in many countries, and developing mucosal vaccines is an efficient strategy to control the influenza virus. The neonatal Fc receptor (FcRn) plays an important role in transf...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2016.11.025

    authors： Yang WT,Yang GL,Wang Q,Huang HB,Jiang YL,Shi CW,Wang JZ,Huang KY,Jin YB,Wang CF

    更新日期：2017-02-01 00:00:00

  • Recombinant pseudorabies virus expressing E2 of classical swine fever virus (CSFV) protects against both virulent pseudorabies virus and CSFV.

    abstract：:Both classical swine fever (CSF) and pseudorabies are highly contagious, economically significant diseases of swine in China. Although vaccination with the C-strain against classical swine fever virus (CSFV) is widely carried out and severe outbreaks of CSF seldom occur in China, CSF is sporadic in many pig herds and ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104652

    authors： Tong W,Zheng H,Li GX,Gao F,Shan TL,Zhou YJ,Yu H,Jiang YF,Yu LX,Li LW,Kong N,Tong GZ,Li JC

    更新日期：2020-01-01 00:00:00

  • 3',5'Di-O-trityluridine inhibits in vitro flavivirus replication.

    abstract：:The dengue fever virus (DENV) and the yellow fever virus (YFV) are members of the genus flavivirus in the family Flaviviridae. An estimated 50-100 million cases of DENV infections occur each year and approximately half a million patients require hospitalization. There is no vaccine or effective antiviral treatment ava...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.01.011

    authors： De Burghgraeve T,Selisko B,Kaptein S,Chatelain G,Leyssen P,Debing Y,Jacobs M,Van Aerschot A,Canard B,Neyts J

    更新日期：2013-05-01 00:00:00

  • Conditionally replicating lentiviral-hybrid episomal vectors for suicide gene therapy.

    abstract：:Lentiviral vectors have been shown to be good candidates for gene transfer protocols; however, prevention of insertional mutagenesis remains problematic. Here we report on the design of a conditionally replicating integrase (IN)-defective lentiviral-hybrid episomal vector in which the insertion of the SV40 promoter/or...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2008.06.015

    authors： Vargas J Jr,Klotman ME,Cara A

    更新日期：2008-12-01 00:00:00

  • Antiviral treatment of Argentine hemorrhagic fever.

    abstract：:Argentine hemorrhagic fever is a systemic viral disease caused by Junin virus, with a mortality of 15-30% in untreated individuals. Current specific therapy is highly effective in reducing mortality, and consists of the early administration of immune plasma in defined doses of specific neutralizing antibodies per kg o...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(94)90030-2

    authors： Enria DA,Maiztegui JI

    更新日期：1994-01-01 00:00:00

  • Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells.

    abstract：:Inosine monophosphate dehydrogenase (IMPDH) catalyzes an essential step in the de novo biosynthesis of guanine nucleotide, namely, the conversion of IMP to XMP. The depletion of the intracellular GTP and dGTP pools is the major event occurring in the cells exposed to the inhibitors such as mycophenolic acid. The prese...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2010.10.009

    authors： Khan M,Dhanwani R,Patro IK,Rao PV,Parida MM

    更新日期：2011-01-01 00:00:00

  • Algorithms for the interpretation of HIV-1 genotypic drug resistance information.

    abstract：:Drug resistance testing has proven its use to guide treatment decisions in HIV-1 infected patients. Genotyping is the preferred technique for clinical drug resistance testing. Many factors complicate the interpretation of mutations towards therapy response, such that an interpretation system is necessary to help the c...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2006.05.003

    authors： Vercauteren J,Vandamme AM

    更新日期：2006-09-01 00:00:00

  • Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells.

    abstract：:Infections by dengue virus (DENV) are increasing worldwide, with an urgent need for effective anti-DENV agents. We recently identified N-(4-hydroxyphenyl) retinamide (4-HPR), an anti-DENV agent effective against all 4 serotypes of DENV in cell culture, and in a lethal mouse model for DENV infection (Fraser et al., 201...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2016.03.006

    authors： Fraser JE,Wang C,Chan KW,Vasudevan SG,Jans DA

    更新日期：2016-06-01 00:00:00

  • Crimean-Congo hemorrhagic fever in Turkey: Current status and future challenges.

    abstract：:Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease of humans that affects a wide geographic area of Africa and Eurasia, including Turkey, Iran, Pakistan, Afghanistan and Russia. Since the first detection of CCHF cases in Turkey in 2002, more than 9700 patients have been reported, with an overall mort...

    journal_title：Antiviral research

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.antiviral.2015.12.003

    authors： Leblebicioglu H,Ozaras R,Irmak H,Sencan I

    更新日期：2016-02-01 00:00:00

  • Baculovirus AcMNPV induces type I interferons and NK/NKT cells-mediated protection against foot-and-mouth disease virus in mice.

    abstract：:Foot-and-mouth disease is a viral illness that affects cloven-hoofed animals causing serious economic losses. Inactivated vaccines against its causative agent, foot-and-mouth disease virus (FMDV), require approximately seven days to induce protection. Therefore, antiviral strategies are needed to provide earlier prote...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2020.104850

    authors： Molina GN,Cacciabue M,Gismondi MI,Taboga O,Molinari P

    更新日期：2020-08-01 00:00:00

  • Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus.

    abstract：:Sixteen herpes simplex virus type 1 (HSV-1) and four type 2 (HSV-2) isolates resistant to acyclovir (ACV) were characterized retrospectively for drug resistance. Phenotypic testing was performed by means of tetrazolium reduction assay and genotypic analysis was carried out by sequencing of thymidine kinase (TK) and DN...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2010.03.002

    authors： Sauerbrei A,Deinhardt S,Zell R,Wutzler P

    更新日期：2010-06-01 00:00:00

  • Combinations of reverse transcriptase, protease, and integrase inhibitors can be synergistic in vitro against drug-sensitive and RT inhibitor-resistant molecular clones of HIV-1.

    abstract：:Combinations of anti-HIV agents including one or two reverse transcriptase inhibitors with a protease inhibitor are potent and effective. However, toxicities, costs and the emergence of drug-resistant organisms have compromised their long-term efficacy in people. A next, likely, target for anti-HIV therapy is HIV-1 in...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(00)00083-8

    authors： Beale KK,Robinson WE Jr

    更新日期：2000-06-01 00:00:00

  • Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.

    abstract：:Antiviral medication is used for the treatment of severe influenza infections, of which the neuraminidase inhibitors (NAIs) are the most effective drugs, approved so far. Here, we investigated the antiviral efficacy of the peptidomimetic furin inhibitor MI-701 in combination with oseltamivir carboxylate and ribavirin ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2015.05.006

    authors： Lu Y,Hardes K,Dahms SO,Böttcher-Friebertshäuser E,Steinmetzer T,Than ME,Klenk HD,Garten W

    更新日期：2015-08-01 00:00:00

  • Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells.

    abstract：:Several nucleoside reverse transcriptase inhibitors are associated with mitochondrial toxicity resulting from inhibition of DNA polymerase-gamma. This study compared the effects on mitochondrial DNA of apricitabine (previously referred to as AVX754 or SPD754), a novel cytidine analogue under development for the treatm...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2007.05.004

    authors： de Baar MP,de Rooij ER,Smolders KG,van Schijndel HB,Timmermans EC,Bethell R

    更新日期：2007-10-01 00:00:00

  • The L1 protein of human papilloma virus 16 expressed by a fowlpox virus recombinant can assemble into virus-like particles in mammalian cell lines but elicits a non-neutralising humoral response.

    abstract：:Human papilloma virus (HPV)-16 is the prevalent genotype associated with cervical tumours. Virus-like-particle (VLP)-based vaccines have proven to be effective in limiting new infections of high-risk HPVs, but their high cost has hampered their use, especially in the poor developing countries. Avipox-based recombinant...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2015.01.012

    authors： Bissa M,Zanotto C,Pacchioni S,Volonté L,Venuti A,Lembo D,De Giuli Morghen C,Radaelli A

    更新日期：2015-04-01 00:00:00

  • Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives.

    abstract：:Several novel γ-carboline derivatives were identified as selective inhibitors of bovine viral diarrhea virus (BVDV) replication in cell cultures. Among them, 3,4,5-trimethyl-γ-carboline (SK3M4M5M) was the most active against BVDV (Nose strain) in MDBK cells, with a 50% effective concentration of 0.017±0.005μM and a se...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2010.09.013

    authors： Salim MT,Goto Y,Hamasaki T,Okamoto M,Aoyama H,Hashimoto Y,Musiu S,Paeshuyse J,Neyts J,Froeyen M,Herdewijn P,Baba M

    更新日期：2010-12-01 00:00:00

  • Design of clinical trials for drug combinations: cytomegalovirus retinitis--foscarnet and ganciclovir. The CMV retinitis retreatment trial.

    abstract：:The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir. Two hundred seventy-nine patients were enrolled and randomly ass...

    journal_title：Antiviral research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0166-3542(95)00921-3

    authors： Jabs DA

    更新日期：1996-01-01 00:00:00

  • An inhibitor of the epidermal growth factor receptor function does not affect the ability of human papillomavirus 11 to form warts in the xenografted immunodeficient mouse model.

    abstract：:Epidermal growth factor receptor (EGFr) has been shown to be induced and activated in cells infected with HPV, suggesting that it may play a physiological role in viral replication or in the formation or maintenance of warts. To investigate this possibility, human foreskin tissue was infected with HPV11 and transplant...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.12.004

    authors： Parkinson T,Howett MK,Welsh PA,Patrick SD,Neely EB,Flanagan N,Pollack VA,Pustilnik LR,Moyer J,Perros M

    更新日期：2007-04-01 00:00:00

  • Pathogenesis and potential antiviral therapy of complications of smallpox vaccination.

    abstract：:Vaccination against smallpox may result in a variety of complications, ranging in severity from benign to lethal. Universal vaccination was halted in the US in 1972, so almost half the present population has never been vaccinated. Because side effects occur most often in first-time vaccinees, current plans for rapid l...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/s0166-3542(03)00008-1

    authors： Bray M

    更新日期：2003-04-01 00:00:00