Abstract：
:Baicalin, a natural product isolated from Scutellariaradix, has been reported to have significant in vivo and in vitro anti-influenza virus activity, but the underlying mechanism remains poorly understood. In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2) in both A549 and Ana-1 cells. The results showed that H3N2 induced autophagy by suppressing mTOR signaling pathway, which however could be significantly inhibited by baicalin. Baicalin could suppress the expression of Atg5-Atg12 complex and LC3-II, and attenuate autophagy induced by starvation. Thus, the inhibition of autophagy induced by virus may account for the antiviral activities of baicalin against H3N2. Autophagy may be a potential marker in developing novel anti-influenza drugs.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Zhu HY,Han L,Shi XL,Wang BL,Huang H,Wang X,Chen DF,Ju DW,Feng MQdoi
10.1016/j.antiviral.2014.11.003subject
Has Abstractpub_date
2015-01-01 00:00:00pages
62-70eissn
0166-3542issn
1872-9096pii
S0166-3542(14)00313-1journal_volume
113pub_type
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