Abstract：
:Many flaviviruses, such as Zika virus (ZIKV), Dengue virus (DENV1-4) and yellow fever virus (YFV), are significant human pathogens. Infection with ZIKV, an emerging mosquito-borne flavivirus, is associated with increased risk of microcephaly in newborns and Guillain-Barré syndrome and other complications in adults. Currently, specific therapy does not exist for any flavivirus infections. In this study, we found that erythrosin B, an FDA-approved food additive, is a potent inhibitor for flaviviruses, including ZIKV and DENV2. Erythrosin B was found to inhibit the DENV2 and ZIKV NS2B-NS3 proteases with IC50 in low micromolar range, via a non-competitive mechanism. Erythrosin B can significantly reduce titers of representative flaviviruses, DENV2, ZIKV, YFV, JEV, and WNV, with micromolar potency and with excellent cytotoxicity profile. Erythrosin B can also inhibit ZIKV replication in ZIKV-relevant human placental and neural progenitor cells. As a pregnancy category B food additive, erythrosin B may represent a promising and easily developed therapy for management of infections by ZIKV and other flaviviruses.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Li Z,Sakamuru S,Huang R,Brecher M,Koetzner CA,Zhang J,Chen H,Qin CF,Zhang QY,Zhou J,Kramer LD,Xia M,Li Hdoi
10.1016/j.antiviral.2017.12.018subject
Has Abstractpub_date
2018-02-01 00:00:00pages
217-225eissn
0166-3542issn
1872-9096pii
S0166-3542(17)30450-3journal_volume
150pub_type
杂志文章abstract：:Natural killer (NK) cells are a crucial component of the host innate immune system. We investigated the noncytolytic anti-human immunodeficiency virus (HIV) activity of NK cells in chronically HIV-infected immune cells. Supernatants collected from NK cell cultures (both primary NK cells and NK cell lines, YTS and NK 9...
journal_title：Antiviral research
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更新日期：2014-05-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：2013-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
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pub_type： 杂志文章
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journal_title：Antiviral research
pub_type： 杂志文章,评审
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更新日期：2013-11-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2016.02.008
更新日期：2016-05-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2008.06.011
更新日期：2008-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0166-3542(93)90082-t
更新日期：1993-09-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2018.10.024
更新日期：2018-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2018.03.008
更新日期：2018-05-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1989-10-01 00:00:00
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更新日期：2021-01-07 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Antiviral research
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更新日期：2016-10-01 00:00:00
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doi：10.1016/0166-3542(81)90017-6
更新日期：1981-11-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2012.09.003
更新日期：2012-11-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2009.07.014
更新日期：2009-10-01 00:00:00
abstract：:AIDS therapies employing HIV protease inhibitors (PIs) are associated with changes in fat metabolism. However, the cellular mechanisms affected by PIs are not clear. Thus, the affects of PIs on adipocyte differentiation were examined in vitro using C3H10T1/2 stem cells. In these cells the PIs, nelfinavir, saquinavir, ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(00)00102-9
更新日期：2000-08-01 00:00:00
