Abstract:
:Drug resistance testing has proven its use to guide treatment decisions in HIV-1 infected patients. Genotyping is the preferred technique for clinical drug resistance testing. Many factors complicate the interpretation of mutations towards therapy response, such that an interpretation system is necessary to help the clinical virologist. No consensus interpretation exists to date and experts often have quite different opinions. As a result, several algorithms for the interpretation of HIV-1 genotypic drug resistance information have been designed. Clinical evaluation of their genotypic interpretation is not always straightforward. We describe a few publicly available systems and their clinical evaluation. We also stress that in addition to drug resistance, for effective management of HIV infection the clinician needs to take into account all potential causes of treatment failure. Successful therapy heavily relies on the expertise of the clinician.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Vercauteren J,Vandamme AMdoi
10.1016/j.antiviral.2006.05.003subject
Has Abstractpub_date
2006-09-01 00:00:00pages
335-42issue
2-3eissn
0166-3542issn
1872-9096pii
S0166-3542(06)00130-6journal_volume
71pub_type
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journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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journal_title:Antiviral research
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Antiviral research
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.antiviral.2016.03.005
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.01.005
更新日期:2011-03-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(98)00051-5
更新日期:1998-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.antiviral.2006.12.004
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pub_type: 杂志文章
doi:10.1016/j.antiviral.2013.10.018
更新日期:2014-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2016.07.017
更新日期:2016-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2015.05.006
更新日期:2015-08-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2007.03.004
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.antiviral.2012.02.001
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journal_title:Antiviral research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2003-04-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2004.08.002
更新日期:2004-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2004.03.005
更新日期:2004-08-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0166-3542(89)90066-1
更新日期:1989-08-01 00:00:00