Abstract:
:Derivatives of beta-lactam antibiotics of the cephalosporin type at 0.02-1 mM concentrations interfered with in vitro replication of two DNA-containing viruses, herpes simplex I and vaccinia, but showed no effects on two RNA-viruses, lymphocytic choriomeningitis virus and vesicular stomatitis virus, or on cell viability. The exact structure of the active compounds remains unknown, but opening of the beta-lactam ring appears to be a prerequisite for their formation. Whereas cephalosporin derivatives were most active, no active products were obtained from penicillins and monobactams. The potential of these unexpected antiviral effects of widely used beta-lactam antibiotics remains subject of further study.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Cottagnoud P,Neftel KA,Hany M,Zinkernagel RMdoi
10.1016/0166-3542(88)90014-9subject
Has Abstractpub_date
1988-11-01 00:00:00pages
59-70issue
1-3eissn
0166-3542issn
1872-9096pii
0166-3542(88)90014-9journal_volume
10pub_type
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更新日期:2021-01-01 00:00:00
abstract::The present study was undertaken to examine the potential of rectal route of immunization for induction of protective immunity in the female genital tract against genital herpes infection in mice. A single rectal immunization of female C57Bl/6 mice with live attenuated herpes simplex virus type 2 lacking thymidine kin...
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更新日期:2008-06-01 00:00:00
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journal_title:Antiviral research
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abstract::Twenty-five years after the discovery of the therapeutic activity of azidothymidine (AZT), the first antiretroviral drug used in the clinic, infection with the human immunodeficiency virus (HIV) has become, at least in the industrialized world, a manageable chronic disease with a significant improvement in life expect...
journal_title:Antiviral research
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2005.11.005
更新日期:2006-03-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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abstract::Previously, we found that a ganciclovir (GCV)-resistant clinical human cytomegalovirus (HCMV) isolate had an amino acid substitution at codon 501 (Leu --> Phe) in the delta-region C of the DNA polymerase gene. DNA polymerases have now been (partially) purified from both the GCV-resistant and sensitive parental strains...
journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
abstract::The internal ribosome entry site (IRES) of hepatitis C virus (HCV) which governs the initiation of protein synthesis from viral RNA represents an ideal target for antisense approaches. Using an original bicistronic plasmid, we first established that sequence and translational activity of HCV IRESs cloned from six pati...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2008.06.011
更新日期:2008-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2008.12.005
更新日期:2009-03-01 00:00:00
abstract::Influenza viruses (IV) continue to pose an imminent threat to human welfare. Yearly re-occurring seasonal epidemic outbreaks and pandemics with high mortality can occur. Besides vaccination against a limited number of viral strains only a few antiviral drugs are available, which are losing their effectiveness as more ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2017.03.024
更新日期:2017-06-01 00:00:00
abstract::The K70E mutation in HIV-1 reverse transcriptase was observed in 10% of virologic non-responders of the abacavir/lamivudine/tenofovir arm of ESS30009, alone, or in mixtures with K65R by population sequencing. Clonal analysis of six ESS30009 K70E isolates failed to identify double mutants carrying K65R+K70E. Site-direc...
journal_title:Antiviral research
pub_type: 杂志文章,随机对照试验
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更新日期:2007-09-01 00:00:00
abstract::The emergence of the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second time that a new, highly pathogenic coronavirus has emerged in the human population in the 21st century. In this review, we discuss the current state of knowledge of animal models of MERS-CoV infection. Commonly used ...
journal_title:Antiviral research
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doi:10.1016/j.antiviral.2015.07.005
更新日期:2015-10-01 00:00:00
abstract::We examined 28 children with HIV-1 infection who were not responding to existing antiviral regimens and were enrolled into clinical trials conducted at the National Cancer Institute to receive salvage therapy. In 3 of the 28 patients (10.7%), the Q151M complex amino acid substitutions were identified. The three patien...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2007.02.004
更新日期:2007-08-01 00:00:00
abstract::A major challenge in the development of vaccines against retroviruses is the induction of neutralizing antibodies since they prevent infection of the cells where the virus may persist. The transmembrane envelope (TM) protein contains highly conserved domains and seems to be a suitable target. To study whether vaccinat...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2010.11.011
更新日期:2011-01-01 00:00:00
abstract::Respiratory syncytial virus (RSV), which presents the primary cause of bronchiolitis and pneumonia among infants and causes significant morbidity and mortality in immunodeficient patients, remains a health problem worldwide. Unfortunately, an effective vaccine is currently unavailable and pharmacologic treatment needs...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2006.02.011
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2015.08.016
更新日期:2015-11-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2000-06-01 00:00:00
abstract::This mosquito-borne pathogen of humans and animals respects no international or geographic boundaries. It is currently found in parts of Africa and the Arabian Peninsula where periodic outbreaks of severe and fatal disease occur, and threatens to spread into other geographic regions. In recent years, modern molecular ...
journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2016.07.005
更新日期:2016-08-01 00:00:00
abstract::T Follicular helper cells (TFH) are considered critical for B cell antibody response, and recent efforts have focused on promoting TFH in order to enhance vaccine efficacy. We studied the frequency and function of TFH in nasopharynx-associated lymphoid tissues (NALT) from children and adults, and its role in anti-infl...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2016.05.021
更新日期:2016-08-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2007-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2019.104677
更新日期:2020-02-01 00:00:00
abstract::A novel substituted naphthalenone (TGG-II-23A) has been found that inhibits HIV-1 infection of CEM-SS cells at concentrations that are not cytotoxic. Time of addition experiments indicate that TGG-II-23A functions at a stage of the HIV-1 life cycle at or near reverse transcription. Cell free assays confirmed that TGG-...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(93)90091-v
更新日期:1993-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2003-06-01 00:00:00
abstract::Forty-nine subjects were enrolled in a study comparing two dosages of parenterally administered interferon (IFN)-beta in combination with cryotherapy for the treatment of anogenital warts. Subjects were randomized to receive subcutaneous injections of either 2 x 10(6) or 4 x 10(6) IU/m2 of IFN-beta (Biogen) three time...
journal_title:Antiviral research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1997-06-01 00:00:00
abstract::Trimming of the N-glycans attached to the envelope proteins of hepatitis B virus (HBV) is required in different steps of the viral life cycle. Inhibition of the host enzymes alpha-glucosidases, involved in the endoplasmic reticulum (ER)-associated processing of the N-linked glycans, results in misfolding of the HBV en...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2007.04.004
更新日期:2007-10-01 00:00:00