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Emergence of human immunodeficiency virus type 1 variants containing the Q151M complex in children receiving long-term antiretroviral chemotherapy.

Abstract：

:We examined 28 children with HIV-1 infection who were not responding to existing antiviral regimens and were enrolled into clinical trials conducted at the National Cancer Institute to receive salvage therapy. In 3 of the 28 patients (10.7%), the Q151M complex amino acid substitutions were identified. The three patients had received nucleoside reverse transcriptase inhibitor (NRTI) monotherapy and/or combination regimens with multiple NRTIs for 4.3-8.6 years prior to the study. Recombinant infectious clones generated by incorporating the RT-encoding region of HIV-1 isolated from patients' plasma samples were highly resistant to zidovudine, didanosine and stavudine, while they were moderately resistant to lamivudine and tenofovir disoproxil fumarate (TDF). TDF-containing regimens reduced HIV-1 viremia in two of the three children carrying the Q151M complex. These data suggest that the Q151M could be prevalent in pediatric patients with long-term NRTI monotherapy and/or dual NRTI regimens and that HAART regimens containing TDF may be meritorious in such patients.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Harada S,Hazra R,Tamiya S,Zeichner SL,Mitsuya H

doi

10.1016/j.antiviral.2007.02.004

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

159-66

issue

2

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(07)00218-5

journal_volume

75

pub_type

杂志文章

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