Abstract：
:Stavudine (d4T) is used extensively as part of HAART in resource poor settings, despite its toxicities. The revised WHO guidelines specify replacement of d4T with less toxic but more expensive drugs when feasible, and that d4T doses be standardized to 30 mg twice daily (bid) (irrespective of body-weight), from the approved 40 mg bid in adults (body-weight ≥60 kg). Therefore, an in silico population pharmacokinetic and biochemical model was utilized to compare relative efficacies of the two doses in humans. Assessment of predicted quartile ranges of simulated concentrations of the triphosphate of d4T suggested sufficient trough concentrations to inhibit wild type HIV-1 reverse transcriptase at the reduced dose, lending support to the revised WHO recommendations.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Hurwitz SJ,Schinazi RFdoi
10.1016/j.antiviral.2011.08.004subject
Has Abstractpub_date
2011-11-01 00:00:00pages
372-7issue
2eissn
0166-3542issn
1872-9096pii
S0166-3542(11)00393-7journal_volume
92pub_type
杂志文章abstract：:Viral hemorrhagic fevers (VHFs) cause thousands of fatalities every year, but the treatment options for their management remain very limited. In particular, the development of therapeutic interventions is restricted by the lack of commercial viability of drugs targeting individual VHF agents. This makes approaches lik...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2019.104569
更新日期：2019-10-01 00:00:00
abstract：:Human parainfluenza virus type 3 (HPIV3) is an important respiratory tract pathogen of infants and children. There are no vaccines or antivirals currently approved for prevention or treatment of HPIV3 infection. Towards developing an antiviral therapy to combat HPIV3 infection, we have established a green fluorescent ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2007.09.001
更新日期：2008-02-01 00:00:00
abstract：:Chronic hepatitis B infection remains a major public health problem worldwide. The hepatitis B virus belongs to the family of hepadnaviruses that replicate their DNA genome via a reverse transcription pathway. The chronicity of infection in infected hepatocytes is maintained by the persistence of the viral covalently ...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/s0166-3542(99)00056-x
更新日期：1999-11-01 00:00:00
abstract：BACKGROUND:Lactoferrin (LF) is a glycoprotein present in human milk with known antimicrobial effects. In vitro, LF has demonstrated antiviral activity against respiratory syncytial virus (RSV). We sought to assess the effect of bovine (b)LF in RSV replication, lung inflammation and function, cytokine profiles and clini...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.05.013
更新日期：2013-08-01 00:00:00
abstract：:SeqHepB is a combination of a HBV genome sequence analysis program and a relational database that houses data collected from multiple data sources. Registered users can access the sequence analysis component of SeqHepB online for rapid and detailed interrogation of HBV genomic sequences. Its main function is to determ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2006.11.014
更新日期：2007-07-01 00:00:00
abstract：:A recombinant baculovirus (vAc-gC1) was constructed that expresses the glycoprotein C (gC) gene of herpes simplex virus type 1 (HSV-1). When Sf9 cells were infected with this recombinant, a protein that was smaller in size than authentic HSV-1 gC was detected by Western blotting using anti-gC polyclonal antibody. The ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(92)90062-a
更新日期：1992-06-01 00:00:00
abstract：:Serum from wild alligators was collected and tested for antibiotic activity against three enveloped viruses using cell-based assays. Alligator serum demonstrated antiviral activities against human immunodeficiency virus type 1 (HIV-1; IC50=0.9%), West Nile virus (WNV; IC50=4.3%), and Herpes simplex virus type 1 (HSV-1...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2004.12.007
更新日期：2005-04-01 00:00:00
abstract：:The ability to control plant viral diseases with chemicals has great potential value for agriculture, but few chemicals are available to date due to the difficulty in obtaining effective drugs. IMP dehydrogenase is an enzyme which catalyzes the conversion of inosine 5'-monophosphate to xanthosine 5'-monophosphate in t...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2006.10.007
更新日期：2007-03-01 00:00:00
abstract：:Influenza A virus has been responsible for widespread human epidemics because it is readily transmitted from humans to humans by aerosol. Recent events have highlighted the potential of influenza A virus as a bioterrorist weapon: the high virulence of the influenza A virus that infected people in Hong Kong in 1997; an...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/s0166-3542(02)00207-3
更新日期：2003-01-01 00:00:00
abstract：:Phosphorothioate-modified oligomers have been shown to be more stable than natural oligomers to serum and cellular nucleases. For this reason we used these analogs to explore the utility of antisense molecules as potential antiviral agents. The oligomers we studied are complementary to the initiation region of the Vmw...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(91)90023-k
更新日期：1991-09-01 00:00:00
abstract：:To identify monoclonal antibodies (mAbs) with high potency and novel recognition sites, more than 25,000 of mouse hybridomas were screened and 4 novel anti-human CCR5 mAbs ROAb12, ROAb13, ROAb14, and ROAb18 showing potent activity in cell-cell fusion (CCF) assay were identified. These mAbs demonstrated potent antivira...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2006.11.003
更新日期：2007-05-01 00:00:00
abstract：:In vitro studies of HBV core promoter mutations in hepatoma cell lines suggest that some mutations in core promoter transcription factor binding sites result in reduced core promoter activity and viral replication. We sought to validate this hypothesis using clinical samples with viral load differences before and afte...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2005.11.005
更新日期：2006-03-01 00:00:00
abstract：:Mycophenolate mofetil (MMF), a therapeutically used inhibitor of inosine monophosphate dehydrogenase is hydrolyzed to its active metabolite mycophenolic acid (MPA) in vivo. MPA exhibits anti-HIV activity in vitro. We tested MPA alone and in combination with abacavir (ABC), didanosine (DDI), lamivudine (3TC) and tenofo...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(02)00006-2
更新日期：2002-07-01 00:00:00
abstract：:While combination antiretroviral therapy (cART) has successfully converted HIV to a chronic but manageable infection in many parts of the world, HIV continues to persist within latent cellular reservoirs, which can become reactivated at any time to produce infectious virus. New therapies are therefore needed not only ...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2018.07.016
更新日期：2018-10-01 00:00:00
abstract：:Hepatitis C virus (HCV) translation is mediated by a highly conserved internal ribosome entry site (IRES), mainly located at the 5'untranslatable region (5'UTR) of the viral genome. Viral protein synthesis clearly differs from that used by most cellular mRNAs, rendering the IRES an attractive target for novel antivira...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2012.02.015
更新日期：2012-05-01 00:00:00
abstract：:This mosquito-borne pathogen of humans and animals respects no international or geographic boundaries. It is currently found in parts of Africa and the Arabian Peninsula where periodic outbreaks of severe and fatal disease occur, and threatens to spread into other geographic regions. In recent years, modern molecular ...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2016.07.005
更新日期：2016-08-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2018.01.002
更新日期：2018-02-01 00:00:00
abstract：:Rotavirus infection has emerged as an important cause of complications in organ transplantation recipients. Immunosuppressants used to prevent alloreactivity can also interfere with virus infection, but the direct effects of the specific type of immunosuppressants on rotavirus infection are still unclear. Here we prof...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2016.07.017
更新日期：2016-09-01 00:00:00
abstract：:Despite an urgent medical need, a broadly effective anti-viral therapy for the treatment of infections with hepatitis C viruses (HCVs) has yet to be developed. One of the approaches to anti-HCV drug discovery is the design and development of specific small molecule drugs to inhibit the proteolytic processing of the HC...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：
更新日期：1999-02-01 00:00:00
abstract：:Development of anti-dengue therapy represents an urgent un-met medical need. Towards antiviral therapy, recent advances in crystal structures of DENV enzymes have led to the possibility of structure-based rational design of inhibitors for anti-dengue therapy. These include (i) the structure of the 'active' form of the...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2012.09.007
更新日期：2012-11-01 00:00:00
abstract：:Amino acid 1092 (AA1092) in capsid protein 1 of coxsackievirus B3 (CVB3) is located in close vicinity to the central phenoxy group of capsid binders (i.e. pleconaril). Whereas isoleucine is associated with drug susceptibility, leucine and methionine confer resistance to pleconaril. In the present study, novel analogue...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2008.09.002
更新日期：2009-01-01 00:00:00
abstract：:Genital herpes, caused by either herpes simplex virus type 1 or 2 (HSV-1 and HSV-2), is a significant public health problem worldwide. It increases the risk of infection with HIV, upregulates HIV after infection and can be associated with serious morbidity and mortality. It is now known that clinical and subclinical v...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2004.06.002
更新日期：2004-08-01 00:00:00
abstract：:Nucleic acid polymers (NAPs) block the release of HBsAg from infected hepatocytes. These compounds have been previously shown to have the unique ability to eliminate serum surface antigen in DHBV-infected Pekin ducks and achieve multilog reduction of HBsAg or HBsAg loss in patients with chronic HBV infection and HBV/H...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2017.10.022
更新日期：2018-01-01 00:00:00
abstract：:Laninamivir, a potent neuraminidase (NA) inhibitor, is an active metabolite of laninamivir octanoate (code name: CS-8958) which is a long acting NA inhibitor and is commercially available under the brand name Inavir in Japan to complete the treatment of influenza by a single inhalation. It is supposed that the long ac...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.08.004
更新日期：2013-10-01 00:00:00
abstract：:Foot-and-mouth disease is a viral illness that affects cloven-hoofed animals causing serious economic losses. Inactivated vaccines against its causative agent, foot-and-mouth disease virus (FMDV), require approximately seven days to induce protection. Therefore, antiviral strategies are needed to provide earlier prote...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2020.104850
更新日期：2020-08-01 00:00:00
abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATLL) has a poor prognosis owing to its intrinsic resistance to chemotherapy. Although zidovudine (AZT) and alpha interferon (IFN-alpha) give rise to some response and improve the prognosis of ATLL, alternative therapies are nee...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2006.02.003
更新日期：2006-07-01 00:00:00
abstract：:Rotavirus (RV) and norovirus (NoV) are the two most important causes of viral gastroenteritis. While vaccine remains an effective prophylactic strategy, development of other approaches, such as passive immunization to control and treat clinical infection and illness of these two pathogens, is necessary. Previously we ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2012.12.011
更新日期：2013-03-01 00:00:00
abstract：:Novel L-lyxo-TSAO-T analogs with an inverted configuration at the C-4'-position of the sugar moiety and 5'-deoxy-5'-modified TSAO-T derivatives have been prepared and evaluated for their inhibitory effect on human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) replication in cell culture. None of the compoun...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(95)00989-2
更新日期：1996-11-01 00:00:00
abstract：:Human influenza viruses isolated from Australasia (Australia and New Zealand) and South East Asia were analysed to determine their sensitivity to the NA inhibitor drugs, zanamivir and oseltamivir. A total of 532 strains isolated between 1998 and 2002 were tested using a fluorescence-based assay to measure the relative...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2003.11.008
更新日期：2004-04-01 00:00:00
abstract：:Tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide) was examined for its activity against tomato-spotted wilt virus (TSWV) in tomato plants. Solutions containing 50, 100, 200, 400 and 800 mg/l of the drug were sprayed onto the leaves. The results showed that 100 and 200 mg/l were the most efficient concentration...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(84)90003-2
更新日期：1984-12-01 00:00:00
